Gastric emptying and gastrointestinal transit during lactation in rats

Tseng Shing Chen, Ming Luen Doong, Shyi Wu Wang, Shiow Chwen Tsai, Chien Chen Lu, Hsi Chang Shih, Yen Hao Chen, Full Young Chang, Shou Dong Lee, Paulus S. Wang

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Female sex hormones can influence gastrointestinal function. To understand whether postpartum changes in female sex hormones may affect such function, gastric emptying and gastrointestinal transit were measured in rats on days 1-2, 10, 15, and 21 of lactation, on day 7 postweaning, and at the nonpregnant diestrous stage. Gastric emptying and gastrointestinal transit were assessed in conscious rats 15 min after intragastric instillation of a test meal containing charcoal and 51Cr. The results showed that gastric emptying was increased throughout the first 2 wk of lactation, with a gradual decrease as lactation proceeded toward weaning, and returned to the level of the virgin rats by 1 wk postweaning. Gastrointestinal transit was greater in the early stage of lactation and was related to gastric emptying (P < 0.001). Increases in gastric emptying and intestinal length were correlated with lactation (P < 0.001) and plasma prolactin levels (P < 0.05) but not with plasma progesterone or estradiol levels. We concluded that the sex steroid hormones associated with lactation do not mediate a change in gastric emptying and gastrointestinal transit during lactation.

Original languageEnglish (US)
Pages (from-to)G626-G631
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume272
Issue number3 35-3
DOIs
StatePublished - Mar 1997

Keywords

  • weaning progesterone

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)

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