Gastric emptying and gastrointestinal transit during lactation in rats

Tseng Shing Chen, Ming Luen Doong, Shyi Wu Wang, Shiow Chwen Tsai, Chien Chen Lu, Hsi Chang Shih, Yen-Hao Chen, Full Young Chang, Shou Dong Lee, Paulus S. Wang

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Female sex hormones can influence gastrointestinal function. To understand whether postpartum changes in female sex hormones may affect such function, gastric emptying and gastrointestinal transit were measured in rats on days 1-2, 10, 15, and 21 of lactation, on day 7 postweaning, and at the nonpregnant diestrous stage. Gastric emptying and gastrointestinal transit were assessed in conscious rats 15 min after intragastric instillation of a test meal containing charcoal and 51Cr. The results showed that gastric emptying was increased throughout the first 2 wk of lactation, with a gradual decrease as lactation proceeded toward weaning, and returned to the level of the virgin rats by 1 wk postweaning. Gastrointestinal transit was greater in the early stage of lactation and was related to gastric emptying (P < 0.001). Increases in gastric emptying and intestinal length were correlated with lactation (P < 0.001) and plasma prolactin levels (P < 0.05) but not with plasma progesterone or estradiol levels. We concluded that the sex steroid hormones associated with lactation do not mediate a change in gastric emptying and gastrointestinal transit during lactation.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume272
Issue number3 35-3
StatePublished - Mar 1 1997

Fingerprint

Gastrointestinal Transit
Gastric Emptying
Lactation
Gonadal Steroid Hormones
Charcoal
Weaning
Prolactin
Postpartum Period
Progesterone
Meals
Estradiol

Keywords

  • weaning progesterone

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)

Cite this

Chen, T. S., Doong, M. L., Wang, S. W., Tsai, S. C., Lu, C. C., Shih, H. C., ... Wang, P. S. (1997). Gastric emptying and gastrointestinal transit during lactation in rats. American Journal of Physiology - Gastrointestinal and Liver Physiology, 272(3 35-3).

Gastric emptying and gastrointestinal transit during lactation in rats. / Chen, Tseng Shing; Doong, Ming Luen; Wang, Shyi Wu; Tsai, Shiow Chwen; Lu, Chien Chen; Shih, Hsi Chang; Chen, Yen-Hao; Chang, Full Young; Lee, Shou Dong; Wang, Paulus S.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 272, No. 3 35-3, 01.03.1997.

Research output: Contribution to journalArticle

Chen, TS, Doong, ML, Wang, SW, Tsai, SC, Lu, CC, Shih, HC, Chen, Y-H, Chang, FY, Lee, SD & Wang, PS 1997, 'Gastric emptying and gastrointestinal transit during lactation in rats', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 272, no. 3 35-3.
Chen, Tseng Shing ; Doong, Ming Luen ; Wang, Shyi Wu ; Tsai, Shiow Chwen ; Lu, Chien Chen ; Shih, Hsi Chang ; Chen, Yen-Hao ; Chang, Full Young ; Lee, Shou Dong ; Wang, Paulus S. / Gastric emptying and gastrointestinal transit during lactation in rats. In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 1997 ; Vol. 272, No. 3 35-3.
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