Gastrulation defective is a serine protease involved in activating the receptor Toll to polarize the Drosophila embryo

Jin Hua Han, Si Hyoung Lee, Yue Qing Tan, Ellen K. LeMosy, Carl Hashimoto

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The dorsoventral axis of the Drosophila embryo is induced by a ventrally restricted ligand for the receptor Toll. The Toll ligand is generated by a proteolytic processing reaction, which occurs at the end of a proteolytic cascade and requires the gastrulation defective (gd), nudel, pipe, and windbeutel genes. Here we demonstrate that the GD protein is a serine protease and that the three other genes act to restrict GD activity to the ventral side of the embryo. Our data support a model in which the GD protease catalyzes the ventral activation of the proteolytic cascade that produces the Toll ligand.

Original languageEnglish (US)
Pages (from-to)9093-9097
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number16
DOIs
StatePublished - Aug 1 2000
Externally publishedYes

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