Gastrulation defective is a serine protease involved in activating the receptor Toll to polarize the Drosophila embryo

Jin Hua Han, Si Hyoung Lee, Yue Qing Tan, Ellen LeMosy, Carl Hashimoto

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The dorsoventral axis of the Drosophila embryo is induced by a ventrally restricted ligand for the receptor Toll. The Toll ligand is generated by a proteolytic processing reaction, which occurs at the end of a proteolytic cascade and requires the gastrulation defective (gd), nudel, pipe, and windbeutel genes. Here we demonstrate that the GD protein is a serine protease and that the three other genes act to restrict GD activity to the ventral side of the embryo. Our data support a model in which the GD protease catalyzes the ventral activation of the proteolytic cascade that produces the Toll ligand.

Original languageEnglish (US)
Pages (from-to)9093-9097
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number16
DOIs
StatePublished - Aug 1 2000

Fingerprint

Gastrulation
Serine Proteases
Drosophila
Embryonic Structures
Ligands
Genes
Peptide Hydrolases
Proteins

ASJC Scopus subject areas

  • General

Cite this

Gastrulation defective is a serine protease involved in activating the receptor Toll to polarize the Drosophila embryo. / Han, Jin Hua; Lee, Si Hyoung; Tan, Yue Qing; LeMosy, Ellen; Hashimoto, Carl.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 16, 01.08.2000, p. 9093-9097.

Research output: Contribution to journalArticle

@article{b1bb94f129164cde95023ba715fe5b0e,
title = "Gastrulation defective is a serine protease involved in activating the receptor Toll to polarize the Drosophila embryo",
abstract = "The dorsoventral axis of the Drosophila embryo is induced by a ventrally restricted ligand for the receptor Toll. The Toll ligand is generated by a proteolytic processing reaction, which occurs at the end of a proteolytic cascade and requires the gastrulation defective (gd), nudel, pipe, and windbeutel genes. Here we demonstrate that the GD protein is a serine protease and that the three other genes act to restrict GD activity to the ventral side of the embryo. Our data support a model in which the GD protease catalyzes the ventral activation of the proteolytic cascade that produces the Toll ligand.",
author = "Han, {Jin Hua} and Lee, {Si Hyoung} and Tan, {Yue Qing} and Ellen LeMosy and Carl Hashimoto",
year = "2000",
month = "8",
day = "1",
doi = "10.1073/pnas.97.16.9093",
language = "English (US)",
volume = "97",
pages = "9093--9097",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "16",

}

TY - JOUR

T1 - Gastrulation defective is a serine protease involved in activating the receptor Toll to polarize the Drosophila embryo

AU - Han, Jin Hua

AU - Lee, Si Hyoung

AU - Tan, Yue Qing

AU - LeMosy, Ellen

AU - Hashimoto, Carl

PY - 2000/8/1

Y1 - 2000/8/1

N2 - The dorsoventral axis of the Drosophila embryo is induced by a ventrally restricted ligand for the receptor Toll. The Toll ligand is generated by a proteolytic processing reaction, which occurs at the end of a proteolytic cascade and requires the gastrulation defective (gd), nudel, pipe, and windbeutel genes. Here we demonstrate that the GD protein is a serine protease and that the three other genes act to restrict GD activity to the ventral side of the embryo. Our data support a model in which the GD protease catalyzes the ventral activation of the proteolytic cascade that produces the Toll ligand.

AB - The dorsoventral axis of the Drosophila embryo is induced by a ventrally restricted ligand for the receptor Toll. The Toll ligand is generated by a proteolytic processing reaction, which occurs at the end of a proteolytic cascade and requires the gastrulation defective (gd), nudel, pipe, and windbeutel genes. Here we demonstrate that the GD protein is a serine protease and that the three other genes act to restrict GD activity to the ventral side of the embryo. Our data support a model in which the GD protease catalyzes the ventral activation of the proteolytic cascade that produces the Toll ligand.

UR - http://www.scopus.com/inward/record.url?scp=12944332084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12944332084&partnerID=8YFLogxK

U2 - 10.1073/pnas.97.16.9093

DO - 10.1073/pnas.97.16.9093

M3 - Article

C2 - 10922064

AN - SCOPUS:12944332084

VL - 97

SP - 9093

EP - 9097

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 16

ER -