Gene therapy, cell transplantation and stroke

Cesario V. Borlongan, Christina Fournier, Christine E. Stahl, Guolong Yu, Lin Xu, Noriyuki Matsukawa, Mary Newman, Takao Yasuhara, Koichi Hara, David C. Hess, Paul R. Sanberg

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

The use of neuroteratocarcinoma cells for transplantation therapy in stroke has emerged as a strategy for cell replacement therapy that has begun its transition from basic science laboratories to a clinical setting. Procurement logistics and novel neuroprotective functions associated with these cells allow neuroteratocarcmoma cells to serve as efficacious alternatives to using fetal cells as donor cell grafts for stroke therapy, although the optimal transplantation regimen must still be determined. In particular, the limitations of current stroke treatments and management reveal an urgent need to examine the efficacy of experimental treatments, such as neural transplantation, in order to develop better treatment therapies. This chapter will discuss the characteristics of NT2N cells, the role of the host brain microenvironment, the need for more rigorous laboratory research and clinical trials for the intracerebral transplantation of NT2N cells in stroke, the mechanisms underlying the grafts' beneficial effects, and the need for immunosuppression. This chapter will highlight some of the most recent findings regarding NT2N cells.

Original languageEnglish (US)
Pages (from-to)1090-1100
Number of pages11
JournalFrontiers in Bioscience
Volume11
Issue number1 P.889-1198
DOIs
StatePublished - Feb 23 2006

Keywords

  • Cancer
  • Gene therapy
  • Intracerebral Transplantation
  • NT2N
  • Nervous system
  • Neuron
  • Neuroprotection
  • Neuroteratocarcinoma Cells
  • Review
  • Stroke
  • Therapeutic
  • Treatment
  • Tumor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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    Borlongan, C. V., Fournier, C., Stahl, C. E., Yu, G., Xu, L., Matsukawa, N., Newman, M., Yasuhara, T., Hara, K., Hess, D. C., & Sanberg, P. R. (2006). Gene therapy, cell transplantation and stroke. Frontiers in Bioscience, 11(1 P.889-1198), 1090-1100. https://doi.org/10.2741/1865