Genetic and environmental influences on echocardiographically determined left ventricular mass in black twins

Gregory A Harshfield, Clarence E. Grim, Chun Hwang, Daniel D. Savage, Sandra J. Anderson

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Genetic and environmental influences on left ventricular mass were examined in normotensive black twins. Left ventricular mass was measured echocardiographically in 7 sets of monozygotic (MZ) and 15 sets of dizygotic (DZ) twins and adjusted for body surface area (LVMI). Regression analyses showed significant effects of gender (R2 = 0.48; P <.01), systolic blood pressure (R2= 0.21; P <.01) and age (R2= 0.10; P <.05) on LVMI but did not show an effect for either diastolic blood pressure or caloric expenditure. Monozygotic twins showed smaller within-pair differences (7 ± 5) than DZ twins (17 ± 11) for LVMI following adjustment for gender, systolic blood pressure and age (P <.03). The intraclass correlation for MZ twins was 0.90 (P <.01) and 0.33 (P = NS) for DZ twins. These results indicate that both genetic and environmental factors are important determinants of left ventricular mass in blacks, independent of gender, blood pressure and age.

Original languageEnglish (US)
Pages (from-to)538-543
Number of pages6
JournalAmerican journal of hypertension
Issue number7
StatePublished - Jul 1990
Externally publishedYes



  • Blacks
  • Deoxycorticosterone
  • Gene-environment interaction
  • Left ventricular hypertrophy
  • Left ventricular mass

ASJC Scopus subject areas

  • Internal Medicine

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