Genetic influences on daytime and night-time blood pressure

Similarities and differences

Xiaoling Wang, Xiuhua Ding, Shaoyong Su, Weili Yan, Gregory A Harshfield, Frank Treiber, Harold Snieder

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

OBJECTIVE: To examine whether the genetic influences on blood pressure (BP) during night-time are different from those during daytime and the extent to which they depend on ethnicity or sex. METHODS: Ambulatory BP was measured in 240 Europeanĝ€"American and 190 Africanĝ€" American twins (mean ± SD age, 17.2 ± 3.4). Individuals with night-time BP falls more than 10% of the daytime values were defined as dippers. A bivariate analysis of the daytime and the night-time BP levels, as well as a liability-threshold model of dippers vs. nondippers were used. RESULTS: Bivariate model fitting showed no ethnic or sex differences for any of the measures, with heritabilities of 0.70 and 0.68 for SBP and 0.70 and 0.64 for DBP at daytime and at night-time. The genetic influences on daytime and night-time were not significantly different for SBP or DBP. The bivariate analysis also indicated that about 56 and 33% of the heritabilities of night-time SBP and DBP could be attributed to genes that also influenced daytime levels. The specific heritabilities due to genetic effects only influencing night-time values were 0.30 for SBP and 0.43 for DBP. The heritabilities of systolic and diastolic dipping were 0.59 and 0.81, respectively. CONCLUSION: Independent of ethnicity and sex, an overlap exists between genes that influence daytime and night-time BP, as well as a significant genetic component that is specific to the night-time BP. These findings suggest that different genes or sets of genes contribute to BP regulation at daytime and night-time.

Original languageEnglish (US)
Pages (from-to)2358-2364
Number of pages7
JournalJournal of hypertension
Volume27
Issue number12
DOIs
StatePublished - Dec 1 2009

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Blood Pressure
Genes
Sex Characteristics
African Americans

Keywords

  • Ambulatory blood pressure monitoring
  • Blacks
  • Dipping
  • Heritability
  • Twin study

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Genetic influences on daytime and night-time blood pressure : Similarities and differences. / Wang, Xiaoling; Ding, Xiuhua; Su, Shaoyong; Yan, Weili; Harshfield, Gregory A; Treiber, Frank; Snieder, Harold.

In: Journal of hypertension, Vol. 27, No. 12, 01.12.2009, p. 2358-2364.

Research output: Contribution to journalArticle

Wang, Xiaoling ; Ding, Xiuhua ; Su, Shaoyong ; Yan, Weili ; Harshfield, Gregory A ; Treiber, Frank ; Snieder, Harold. / Genetic influences on daytime and night-time blood pressure : Similarities and differences. In: Journal of hypertension. 2009 ; Vol. 27, No. 12. pp. 2358-2364.
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AU - Su, Shaoyong

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AU - Harshfield, Gregory A

AU - Treiber, Frank

AU - Snieder, Harold

PY - 2009/12/1

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N2 - OBJECTIVE: To examine whether the genetic influences on blood pressure (BP) during night-time are different from those during daytime and the extent to which they depend on ethnicity or sex. METHODS: Ambulatory BP was measured in 240 Europeanĝ€"American and 190 Africanĝ€" American twins (mean ± SD age, 17.2 ± 3.4). Individuals with night-time BP falls more than 10% of the daytime values were defined as dippers. A bivariate analysis of the daytime and the night-time BP levels, as well as a liability-threshold model of dippers vs. nondippers were used. RESULTS: Bivariate model fitting showed no ethnic or sex differences for any of the measures, with heritabilities of 0.70 and 0.68 for SBP and 0.70 and 0.64 for DBP at daytime and at night-time. The genetic influences on daytime and night-time were not significantly different for SBP or DBP. The bivariate analysis also indicated that about 56 and 33% of the heritabilities of night-time SBP and DBP could be attributed to genes that also influenced daytime levels. The specific heritabilities due to genetic effects only influencing night-time values were 0.30 for SBP and 0.43 for DBP. The heritabilities of systolic and diastolic dipping were 0.59 and 0.81, respectively. CONCLUSION: Independent of ethnicity and sex, an overlap exists between genes that influence daytime and night-time BP, as well as a significant genetic component that is specific to the night-time BP. These findings suggest that different genes or sets of genes contribute to BP regulation at daytime and night-time.

AB - OBJECTIVE: To examine whether the genetic influences on blood pressure (BP) during night-time are different from those during daytime and the extent to which they depend on ethnicity or sex. METHODS: Ambulatory BP was measured in 240 Europeanĝ€"American and 190 Africanĝ€" American twins (mean ± SD age, 17.2 ± 3.4). Individuals with night-time BP falls more than 10% of the daytime values were defined as dippers. A bivariate analysis of the daytime and the night-time BP levels, as well as a liability-threshold model of dippers vs. nondippers were used. RESULTS: Bivariate model fitting showed no ethnic or sex differences for any of the measures, with heritabilities of 0.70 and 0.68 for SBP and 0.70 and 0.64 for DBP at daytime and at night-time. The genetic influences on daytime and night-time were not significantly different for SBP or DBP. The bivariate analysis also indicated that about 56 and 33% of the heritabilities of night-time SBP and DBP could be attributed to genes that also influenced daytime levels. The specific heritabilities due to genetic effects only influencing night-time values were 0.30 for SBP and 0.43 for DBP. The heritabilities of systolic and diastolic dipping were 0.59 and 0.81, respectively. CONCLUSION: Independent of ethnicity and sex, an overlap exists between genes that influence daytime and night-time BP, as well as a significant genetic component that is specific to the night-time BP. These findings suggest that different genes or sets of genes contribute to BP regulation at daytime and night-time.

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