Genetic testing for lung cancer risk: If physicians can do it, should they?

Theodore W. Marcy, Michael Stefanek, Kimberly M. Thompson

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Advances in genetics have increased our ability to assess an individual's genetic risk for disease. There is a hypothesis that genetic test results will motivate high-risk individuals to reduce harmful exposures, to increase their surveillance for disease, or to seek preventive treatments. However, genetic testing for genes associated with an increased risk of lung cancer would not change physicians' recommendations regarding smoking cessation. Limited studies suggest that test results that demonstrate an increased risk of lung cancer do not improve smoking cessation success. These test results may even distort an individual's risk perceptions. Before recommending genetic testing to assess risk for disease, physicians need to consider whether knowledge about genetic susceptibility will alter patient management.

Original languageEnglish (US)
Pages (from-to)946-951
Number of pages6
JournalJournal of General Internal Medicine
Volume17
Issue number12
DOIs
StatePublished - Jan 1 2002

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Keywords

  • Genetic counseling
  • Genetic screening
  • Lung neoplasms
  • Smoking

ASJC Scopus subject areas

  • Internal Medicine

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