Genome-wide analysis of HOXC9-induced neuronal differentiation of neuroblastoma cells

Xiangwei Wang; Liqun Yang; Jeong Hyeon Choi; Eiko Kitamura; Chang Sheng Chang; Jane Ding; Eun J. Lee; Hongjuan Cui; Han Fei Ding

doi:10.1016/j.gdata.2014.04.002

Genome-wide analysis of HOXC9-induced neuronal differentiation of neuroblastoma cells

Xiangwei Wang, Liqun Yang, Jeong Hyeon Choi, Eiko Kitamura, Chang Sheng Chang, Jane Ding, Eun J. Lee, Hongjuan Cui, Han Fei Ding

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Induction of differentiation is a therapeutic strategy in neuroblastoma, a common pediatric cancer of the sympathetic nervous system. The homeobox protein HOXC9 is a key regulator of neuroblastoma differentiation. To gain a molecular understanding of the function of HOXC9 in promoting differentiation of neuroblastoma cells, we conducted a genome-wide analysis of the HOXC9-induced differentiation program by microarray gene expression profiling and chromatin immunoprecipitation in combination with massively parallel sequencing (ChIP-seq). Here we describe in detail the experimental system, methods, and quality control for the generation of the microarray and ChIP-seq data associated with our recent publication [1].

Original language	English (US)
Pages (from-to)	50-52
Number of pages	3
Journal	Genomics Data
Volume	2
DOIs	https://doi.org/10.1016/j.gdata.2014.04.002
State	Published - 2014

Keywords

Differentiation
HOXC9
Neuroblastoma

ASJC Scopus subject areas

Biotechnology
Biochemistry
Molecular Medicine
Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.gdata.2014.04.002

Cite this

@article{b9e25e8cc26c49068c2087feb5ad83f3,

title = "Genome-wide analysis of HOXC9-induced neuronal differentiation of neuroblastoma cells",

abstract = "Induction of differentiation is a therapeutic strategy in neuroblastoma, a common pediatric cancer of the sympathetic nervous system. The homeobox protein HOXC9 is a key regulator of neuroblastoma differentiation. To gain a molecular understanding of the function of HOXC9 in promoting differentiation of neuroblastoma cells, we conducted a genome-wide analysis of the HOXC9-induced differentiation program by microarray gene expression profiling and chromatin immunoprecipitation in combination with massively parallel sequencing (ChIP-seq). Here we describe in detail the experimental system, methods, and quality control for the generation of the microarray and ChIP-seq data associated with our recent publication [1].",

keywords = "Differentiation, HOXC9, Neuroblastoma",

author = "Xiangwei Wang and Liqun Yang and Choi, {Jeong Hyeon} and Eiko Kitamura and Chang, {Chang Sheng} and Jane Ding and Lee, {Eun J.} and Hongjuan Cui and Ding, {Han Fei}",

note = "Publisher Copyright: {\textcopyright} 2014 The Authors.",

year = "2014",

doi = "10.1016/j.gdata.2014.04.002",

language = "English (US)",

volume = "2",

pages = "50--52",

journal = "Genomics Data",

issn = "2213-5960",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Genome-wide analysis of HOXC9-induced neuronal differentiation of neuroblastoma cells

AU - Wang, Xiangwei

AU - Yang, Liqun

AU - Choi, Jeong Hyeon

AU - Kitamura, Eiko

AU - Chang, Chang Sheng

AU - Ding, Jane

AU - Lee, Eun J.

AU - Cui, Hongjuan

AU - Ding, Han Fei

PY - 2014

Y1 - 2014

N2 - Induction of differentiation is a therapeutic strategy in neuroblastoma, a common pediatric cancer of the sympathetic nervous system. The homeobox protein HOXC9 is a key regulator of neuroblastoma differentiation. To gain a molecular understanding of the function of HOXC9 in promoting differentiation of neuroblastoma cells, we conducted a genome-wide analysis of the HOXC9-induced differentiation program by microarray gene expression profiling and chromatin immunoprecipitation in combination with massively parallel sequencing (ChIP-seq). Here we describe in detail the experimental system, methods, and quality control for the generation of the microarray and ChIP-seq data associated with our recent publication [1].

AB - Induction of differentiation is a therapeutic strategy in neuroblastoma, a common pediatric cancer of the sympathetic nervous system. The homeobox protein HOXC9 is a key regulator of neuroblastoma differentiation. To gain a molecular understanding of the function of HOXC9 in promoting differentiation of neuroblastoma cells, we conducted a genome-wide analysis of the HOXC9-induced differentiation program by microarray gene expression profiling and chromatin immunoprecipitation in combination with massively parallel sequencing (ChIP-seq). Here we describe in detail the experimental system, methods, and quality control for the generation of the microarray and ChIP-seq data associated with our recent publication [1].

KW - Differentiation

KW - HOXC9

KW - Neuroblastoma

UR - http://www.scopus.com/inward/record.url?scp=84920564521&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920564521&partnerID=8YFLogxK

U2 - 10.1016/j.gdata.2014.04.002

DO - 10.1016/j.gdata.2014.04.002

M3 - Article

AN - SCOPUS:84920564521

SN - 2213-5960

VL - 2

SP - 50

EP - 52

JO - Genomics Data

JF - Genomics Data

ER -

Genome-wide analysis of HOXC9-induced neuronal differentiation of neuroblastoma cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this