Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

J. C. Barrett, D. G. Clayton, P. Concannon, B. Akolkar, J. D. Cooper, H. A. Erlich, C. Julier, G. Morahan, J. Nerup, C. Nierras, V. Plagnol, F. Pociot, H. Schuilenburg, D. J. Smyth, H. Stevens, J. A. Todd, N. M. Walker, S. S. Rich, T. Baskerville, N. Bautista & 380 others E. Bhatia, V. Bhatia, K. Bin Hasan, F. Bonnici, T. Brodnicki, F. Cameron, K. Chaichanwatanakul, P. T. Cheung, P. Colman, A. Cotterill, J. Couper, R. Cutfield, T. Davis, P. Dixon, K. Donaghue, K. Dowling, P. Drury, S. Dye, S. Gellert, R. Abdul Ghani, R. Greer, X. Han, L. Harrison, N. Homatopoulos, L. Ji, T. Jones, L. K. Yin, N. A. Kamaruddin, U. Kanga, A. Kanungo, G. Kaur, B. Kek, S. Knowles, J. Krebs, N. Kumar, Y. J. Lee, X. Li, S. Liktimaskul, M. Lloyd, A. Loth, A. Louey, N. Mehra, T. Merriman, L. Min, G. Morahan, R. Moses, G. Mraz, R. Murphy, I. Nicholson, A. Panelo, P. Poh, G. Price, N. Ratnam, C. Sanjeevi, S. Sedimbi, S. Shen, G. S. Ying, B. Tait, N. Tandon, A. Thomas, M. Varney, P. Weerakulwattana, J. Willis, L. Albret, F. Ampudia-Blasco, J. Argente, G. Babadjanova, K. Badenhoop, T. Battelino, G. Beilhack, R. Bergholdt, P. Bingley, B. Boehm, J. Bolidson, C. Brorsson, J. Carlson, L. Castano, K. Chandler, O. Cinek, E. Cipponeri, R. Corripio, B. Garcia Cuartero, A. de Leiva, A. Fagulha, M. Fernandez Balcells, C. Guja, P. Gutierrez, E. Hatziagelaki, S. Heath, W. Helmberg, M. Hernandez, I. Holzheu, N. Hosszufalusi, C. Ionescu-Tirgoviste, J. Johannesen, C. Julier, H. Kahles, M. Knip, I. Kockum, E. Kojo, K. Koprivarova, O. Kordonouri, A. Kretowski, D. Krikovszky, A. Kurkhaus, N. Lalic, E. Lavant, A. Long, J. Ludvigsson, L. Madacsy, M. Marga, D. Mauricio, G. Mazurkievicz, J. Nerup, F. J. Novoa Mogollon, M. T. Petersen, M. Phillip, V. Pirags, F. Pociot, P. Pozzilli, R. Rappner, B. Roep, S. Rokni, S. Rosinger, O. Rubio-Cabezas, C. Ruckgaber, I. Satman, E. Schober, J. Seufert, R. Sing, J. Skrha, E. Sobngwi, M. Somerville, G. Spinas, V. Tilmann, D. Undlien, V. Urbanavicius, B. Van der Auwera, F. Vasquez San Miguel, A. Vazeo-Gerasimidi, D. Velickiene, A. Wagner, A. Williams, M. Wurzburger, A. Ziegler, M. Agleham, A. Aldrich, R. Alemzadeh, T. Aly, S. Arora, A. Austin, D. Becker, C. Benoist, N. Berka, S. Bhatia, P. Bonella, N. Bottini, S. Boyle, B. Brady, W. Brickman, R. Christensen, P. Concannon, R. Couch, D. Counts, J. Crandall, M. Daniels, L. Dolan, D. Donaldson, A. Doria, G. Eisenbarth, R. El-Hajj, H. Erlich, P. Fain, A. L. Fear, R. Ferry, R. Fiallo-Scharer, S. Ghosh, S. Gitelman, M. Godwin, R. Goland, N. Goodman, G. Goodwin, J. Gravely, C. Greenbaum, C. Gudgeon, F. Gunville, W. Hagopian, H. Hakonarson, J. Hansen, K. Harrington, J. Hassing, W. Hilliker, R. Hoffman, E. Hulbert, R. Izquierdo, N. Jospe, K. Kaiserman, F. Kaufman, S. Kim, E. Kloos, R. Kosoy, J. Lane, J. Lane, J. Lawrence, C. Levetan, P. Levin, R. Lipton, J. Lonsdale, V. Magnuson, J. Marks, B. Mayer-Davis, R. McEvoy, Richard A McIndoe, L. Merkle, D. Metzger, D. Miao, E. Mickelson, P. Moonsamy, W. Moore, A. Moran, J. Noble, G. Olsem, S. Onengut-Gumuscu, T. Orban, C. Orlowski, A. Paterson, M. Pietropaolo, C. Pihoker, C. Polychronakos, J. Post, D. Postellon, A. Pugliese, H. Qu, T. Quattrin, M. Rappaport, P. Raskin, H. Risbeck, H. Rodriguez, L. Rodriguez, M. Rogers, B. Russell, D. Schatz, C. Scott, Jin-Xiong She, D. Shulman, L. Soyka, P. Speiser, H. Starkman, A. Steck, S. Stender, L. Stratton, D. Sur, S. Taback, K. Thrailkill, E. Toth, P. Trymbiski, E. Tsalikian, K. Vertachnik, J. Wahlen, X. Wang, S. Weber, D. Wherrett, S. Willi, D. Wilson, J. Youkey, N. Young, L. Yu, D. Zimmerman, E. Adlem, J. Allen, J. Brown, O. Burren, P. Clarke, D. Clayton, G. Coleman, J. Cooper, Francesco Cucca, S. Duley, D. Dunger, V. Everett, M. Hardy, D. Harrison, I. Harrison, S. Hawkins, B. Healy, S. Hood, S. Howell, M. Maisuria, W. Meadows, T. Mistry, S. Nutland, N. Ovington, H. Schuilenburg, A. Simpson, L. Smink, H. Stevens, N. Taylor, J. Todd, J. Tuomilehto, N. Walker, B. Widmer, M. Wilson, H. Withers, M. Brown, W. M. Chen, A. Crews, J. Griffin, M. Hall, T. Harnish, J. Hepler, J. Hilner, N. King, K. Lohman, L. Lu, J. Mychaleckyj, J. Nail, L. Perdue, J. Pierce, D. Reboussin, S. Rich, S. Rushing, M. Sale, E. Sides, B. Snively, H. Teuschler, G. Theil, D. Williams, B. Akolkar, C. McKeon, C. Nierras, E. Thomson, D. Altshuler, K. Au, S. Bain, L. Barcellos, S. Barral, T. Becker, F. Briggs, P. Bronson, M. Daly, P. de Bakker, P. Deloukas, B. Devlin, M. C. Eike, L. Field, S. Gabriel, N. Garge, S. Gaudieri, B. Goldstein, C. Gorodezky, S. Hamon, C. He, J. Howson, K. Humphreys, I. James, M. Lathrop, B. A. Lie, D. Li, S. Mack, R. McGinnis, E. McKinnon, W. McLaren, D. Nolan, M. Olsson, J. Ott, D. Owerbach, C. Patterson, R. Podolsky, P. Ramsay, V. Rangantah, N. Risch, K. S. Ronningen, X. Shao, R. Single, M. Steffes, G. Thomson, A. M. Valdes, C. Vandiedonck, P. Whittaker, Q. Zhang

Research output: Contribution to journal › Article

1045 Citations (Scopus)

Abstract

Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P 10 6). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P 0.01; overall P 5 × 10 8) and 4 additional regions provided nominal evidence of replication (P 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.

Original languageEnglish (US)
Pages (from-to)703-707
Number of pages5
JournalNature Genetics
Volume41
Issue number6
DOIs
StatePublished - Jun 1 2009
Externally publishedYes

Fingerprint

Genome-Wide Association Study
Type 1 Diabetes Mellitus
Meta-Analysis
Interleukin-27
Interleukin-10
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Barrett, J. C., Clayton, D. G., Concannon, P., Akolkar, B., Cooper, J. D., Erlich, H. A., ... Zhang, Q. (2009). Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nature Genetics, 41(6), 703-707. https://doi.org/10.1038/ng.381

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. / Barrett, J. C.; Clayton, D. G.; Concannon, P.; Akolkar, B.; Cooper, J. D.; Erlich, H. A.; Julier, C.; Morahan, G.; Nerup, J.; Nierras, C.; Plagnol, V.; Pociot, F.; Schuilenburg, H.; Smyth, D. J.; Stevens, H.; Todd, J. A.; Walker, N. M.; Rich, S. S.; Baskerville, T.; Bautista, N.; Bhatia, E.; Bhatia, V.; Bin Hasan, K.; Bonnici, F.; Brodnicki, T.; Cameron, F.; Chaichanwatanakul, K.; Cheung, P. T.; Colman, P.; Cotterill, A.; Couper, J.; Cutfield, R.; Davis, T.; Dixon, P.; Donaghue, K.; Dowling, K.; Drury, P.; Dye, S.; Gellert, S.; Abdul Ghani, R.; Greer, R.; Han, X.; Harrison, L.; Homatopoulos, N.; Ji, L.; Jones, T.; Yin, L. K.; Kamaruddin, N. A.; Kanga, U.; Kanungo, A.; Kaur, G.; Kek, B.; Knowles, S.; Krebs, J.; Kumar, N.; Lee, Y. J.; Li, X.; Liktimaskul, S.; Lloyd, M.; Loth, A.; Louey, A.; Mehra, N.; Merriman, T.; Min, L.; Morahan, G.; Moses, R.; Mraz, G.; Murphy, R.; Nicholson, I.; Panelo, A.; Poh, P.; Price, G.; Ratnam, N.; Sanjeevi, C.; Sedimbi, S.; Shen, S.; Ying, G. S.; Tait, B.; Tandon, N.; Thomas, A.; Varney, M.; Weerakulwattana, P.; Willis, J.; Albret, L.; Ampudia-Blasco, F.; Argente, J.; Babadjanova, G.; Badenhoop, K.; Battelino, T.; Beilhack, G.; Bergholdt, R.; Bingley, P.; Boehm, B.; Bolidson, J.; Brorsson, C.; Carlson, J.; Castano, L.; Chandler, K.; Cinek, O.; Cipponeri, E.; Corripio, R.; Garcia Cuartero, B.; de Leiva, A.; Fagulha, A.; Fernandez Balcells, M.; Guja, C.; Gutierrez, P.; Hatziagelaki, E.; Heath, S.; Helmberg, W.; Hernandez, M.; Holzheu, I.; Hosszufalusi, N.; Ionescu-Tirgoviste, C.; Johannesen, J.; Julier, C.; Kahles, H.; Knip, M.; Kockum, I.; Kojo, E.; Koprivarova, K.; Kordonouri, O.; Kretowski, A.; Krikovszky, D.; Kurkhaus, A.; Lalic, N.; Lavant, E.; Long, A.; Ludvigsson, J.; Madacsy, L.; Marga, M.; Mauricio, D.; Mazurkievicz, G.; Nerup, J.; Novoa Mogollon, F. J.; Petersen, M. T.; Phillip, M.; Pirags, V.; Pociot, F.; Pozzilli, P.; Rappner, R.; Roep, B.; Rokni, S.; Rosinger, S.; Rubio-Cabezas, O.; Ruckgaber, C.; Satman, I.; Schober, E.; Seufert, J.; Sing, R.; Skrha, J.; Sobngwi, E.; Somerville, M.; Spinas, G.; Tilmann, V.; Undlien, D.; Urbanavicius, V.; Van der Auwera, B.; Vasquez San Miguel, F.; Vazeo-Gerasimidi, A.; Velickiene, D.; Wagner, A.; Williams, A.; Wurzburger, M.; Ziegler, A.; Agleham, M.; Aldrich, A.; Alemzadeh, R.; Aly, T.; Arora, S.; Austin, A.; Becker, D.; Benoist, C.; Berka, N.; Bhatia, S.; Bonella, P.; Bottini, N.; Boyle, S.; Brady, B.; Brickman, W.; Christensen, R.; Concannon, P.; Couch, R.; Counts, D.; Crandall, J.; Daniels, M.; Dolan, L.; Donaldson, D.; Doria, A.; Eisenbarth, G.; El-Hajj, R.; Erlich, H.; Fain, P.; Fear, A. L.; Ferry, R.; Fiallo-Scharer, R.; Ghosh, S.; Gitelman, S.; Godwin, M.; Goland, R.; Goodman, N.; Goodwin, G.; Gravely, J.; Greenbaum, C.; Gudgeon, C.; Gunville, F.; Hagopian, W.; Hakonarson, H.; Hansen, J.; Harrington, K.; Hassing, J.; Hilliker, W.; Hoffman, R.; Hulbert, E.; Izquierdo, R.; Jospe, N.; Kaiserman, K.; Kaufman, F.; Kim, S.; Kloos, E.; Kosoy, R.; Lane, J.; Lane, J.; Lawrence, J.; Levetan, C.; Levin, P.; Lipton, R.; Lonsdale, J.; Magnuson, V.; Marks, J.; Mayer-Davis, B.; McEvoy, R.; McIndoe, Richard A; Merkle, L.; Metzger, D.; Miao, D.; Mickelson, E.; Moonsamy, P.; Moore, W.; Moran, A.; Noble, J.; Olsem, G.; Onengut-Gumuscu, S.; Orban, T.; Orlowski, C.; Paterson, A.; Pietropaolo, M.; Pihoker, C.; Polychronakos, C.; Post, J.; Postellon, D.; Pugliese, A.; Qu, H.; Quattrin, T.; Rappaport, M.; Raskin, P.; Risbeck, H.; Rodriguez, H.; Rodriguez, L.; Rogers, M.; Russell, B.; Schatz, D.; Scott, C.; She, Jin-Xiong; Shulman, D.; Soyka, L.; Speiser, P.; Starkman, H.; Steck, A.; Stender, S.; Stratton, L.; Sur, D.; Taback, S.; Thrailkill, K.; Toth, E.; Trymbiski, P.; Tsalikian, E.; Vertachnik, K.; Wahlen, J.; Wang, X.; Weber, S.; Wherrett, D.; Willi, S.; Wilson, D.; Youkey, J.; Young, N.; Yu, L.; Zimmerman, D.; Adlem, E.; Allen, J.; Brown, J.; Burren, O.; Clarke, P.; Clayton, D.; Coleman, G.; Cooper, J.; Cucca, Francesco; Duley, S.; Dunger, D.; Everett, V.; Hardy, M.; Harrison, D.; Harrison, I.; Hawkins, S.; Healy, B.; Hood, S.; Howell, S.; Maisuria, M.; Meadows, W.; Mistry, T.; Nutland, S.; Ovington, N.; Schuilenburg, H.; Simpson, A.; Smink, L.; Stevens, H.; Taylor, N.; Todd, J.; Tuomilehto, J.; Walker, N.; Widmer, B.; Wilson, M.; Withers, H.; Brown, M.; Chen, W. M.; Crews, A.; Griffin, J.; Hall, M.; Harnish, T.; Hepler, J.; Hilner, J.; King, N.; Lohman, K.; Lu, L.; Mychaleckyj, J.; Nail, J.; Perdue, L.; Pierce, J.; Reboussin, D.; Rich, S.; Rushing, S.; Sale, M.; Sides, E.; Snively, B.; Teuschler, H.; Theil, G.; Williams, D.; Akolkar, B.; McKeon, C.; Nierras, C.; Thomson, E.; Altshuler, D.; Au, K.; Bain, S.; Barcellos, L.; Barral, S.; Becker, T.; Briggs, F.; Bronson, P.; Daly, M.; de Bakker, P.; Deloukas, P.; Devlin, B.; Eike, M. C.; Field, L.; Gabriel, S.; Garge, N.; Gaudieri, S.; Goldstein, B.; Gorodezky, C.; Hamon, S.; He, C.; Howson, J.; Humphreys, K.; James, I.; Lathrop, M.; Lie, B. A.; Li, D.; Mack, S.; McGinnis, R.; McKinnon, E.; McLaren, W.; Nolan, D.; Olsson, M.; Ott, J.; Owerbach, D.; Patterson, C.; Podolsky, R.; Ramsay, P.; Rangantah, V.; Risch, N.; Ronningen, K. S.; Shao, X.; Single, R.; Steffes, M.; Thomson, G.; Valdes, A. M.; Vandiedonck, C.; Whittaker, P.; Zhang, Q.

In: Nature Genetics, Vol. 41, No. 6, 01.06.2009, p. 703-707.

Research output: Contribution to journal › Article

Barrett, JC, Clayton, DG, Concannon, P, Akolkar, B, Cooper, JD, Erlich, HA, Julier, C, Morahan, G, Nerup, J, Nierras, C, Plagnol, V, Pociot, F, Schuilenburg, H, Smyth, DJ, Stevens, H, Todd, JA, Walker, NM, Rich, SS, Baskerville, T, Bautista, N, Bhatia, E, Bhatia, V, Bin Hasan, K, Bonnici, F, Brodnicki, T, Cameron, F, Chaichanwatanakul, K, Cheung, PT, Colman, P, Cotterill, A, Couper, J, Cutfield, R, Davis, T, Dixon, P, Donaghue, K, Dowling, K, Drury, P, Dye, S, Gellert, S, Abdul Ghani, R, Greer, R, Han, X, Harrison, L, Homatopoulos, N, Ji, L, Jones, T, Yin, LK, Kamaruddin, NA, Kanga, U, Kanungo, A, Kaur, G, Kek, B, Knowles, S, Krebs, J, Kumar, N, Lee, YJ, Li, X, Liktimaskul, S, Lloyd, M, Loth, A, Louey, A, Mehra, N, Merriman, T, Min, L, Morahan, G, Moses, R, Mraz, G, Murphy, R, Nicholson, I, Panelo, A, Poh, P, Price, G, Ratnam, N, Sanjeevi, C, Sedimbi, S, Shen, S, Ying, GS, Tait, B, Tandon, N, Thomas, A, Varney, M, Weerakulwattana, P, Willis, J, Albret, L, Ampudia-Blasco, F, Argente, J, Babadjanova, G, Badenhoop, K, Battelino, T, Beilhack, G, Bergholdt, R, Bingley, P, Boehm, B, Bolidson, J, Brorsson, C, Carlson, J, Castano, L, Chandler, K, Cinek, O, Cipponeri, E, Corripio, R, Garcia Cuartero, B, de Leiva, A, Fagulha, A, Fernandez Balcells, M, Guja, C, Gutierrez, P, Hatziagelaki, E, Heath, S, Helmberg, W, Hernandez, M, Holzheu, I, Hosszufalusi, N, Ionescu-Tirgoviste, C, Johannesen, J, Julier, C, Kahles, H, Knip, M, Kockum, I, Kojo, E, Koprivarova, K, Kordonouri, O, Kretowski, A, Krikovszky, D, Kurkhaus, A, Lalic, N, Lavant, E, Long, A, Ludvigsson, J, Madacsy, L, Marga, M, Mauricio, D, Mazurkievicz, G, Nerup, J, Novoa Mogollon, FJ, Petersen, MT, Phillip, M, Pirags, V, Pociot, F, Pozzilli, P, Rappner, R, Roep, B, Rokni, S, Rosinger, S, Rubio-Cabezas, O, Ruckgaber, C, Satman, I, Schober, E, Seufert, J, Sing, R, Skrha, J, Sobngwi, E, Somerville, M, Spinas, G, Tilmann, V, Undlien, D, Urbanavicius, V, Van der Auwera, B, Vasquez San Miguel, F, Vazeo-Gerasimidi, A, Velickiene, D, Wagner, A, Williams, A, Wurzburger, M, Ziegler, A, Agleham, M, Aldrich, A, Alemzadeh, R, Aly, T, Arora, S, Austin, A, Becker, D, Benoist, C, Berka, N, Bhatia, S, Bonella, P, Bottini, N, Boyle, S, Brady, B, Brickman, W, Christensen, R, Concannon, P, Couch, R, Counts, D, Crandall, J, Daniels, M, Dolan, L, Donaldson, D, Doria, A, Eisenbarth, G, El-Hajj, R, Erlich, H, Fain, P, Fear, AL, Ferry, R, Fiallo-Scharer, R, Ghosh, S, Gitelman, S, Godwin, M, Goland, R, Goodman, N, Goodwin, G, Gravely, J, Greenbaum, C, Gudgeon, C, Gunville, F, Hagopian, W, Hakonarson, H, Hansen, J, Harrington, K, Hassing, J, Hilliker, W, Hoffman, R, Hulbert, E, Izquierdo, R, Jospe, N, Kaiserman, K, Kaufman, F, Kim, S, Kloos, E, Kosoy, R, Lane, J, Lane, J, Lawrence, J, Levetan, C, Levin, P, Lipton, R, Lonsdale, J, Magnuson, V, Marks, J, Mayer-Davis, B, McEvoy, R, McIndoe, RA, Merkle, L, Metzger, D, Miao, D, Mickelson, E, Moonsamy, P, Moore, W, Moran, A, Noble, J, Olsem, G, Onengut-Gumuscu, S, Orban, T, Orlowski, C, Paterson, A, Pietropaolo, M, Pihoker, C, Polychronakos, C, Post, J, Postellon, D, Pugliese, A, Qu, H, Quattrin, T, Rappaport, M, Raskin, P, Risbeck, H, Rodriguez, H, Rodriguez, L, Rogers, M, Russell, B, Schatz, D, Scott, C, She, J-X, Shulman, D, Soyka, L, Speiser, P, Starkman, H, Steck, A, Stender, S, Stratton, L, Sur, D, Taback, S, Thrailkill, K, Toth, E, Trymbiski, P, Tsalikian, E, Vertachnik, K, Wahlen, J, Wang, X, Weber, S, Wherrett, D, Willi, S, Wilson, D, Youkey, J, Young, N, Yu, L, Zimmerman, D, Adlem, E, Allen, J, Brown, J, Burren, O, Clarke, P, Clayton, D, Coleman, G, Cooper, J, Cucca, F, Duley, S, Dunger, D, Everett, V, Hardy, M, Harrison, D, Harrison, I, Hawkins, S, Healy, B, Hood, S, Howell, S, Maisuria, M, Meadows, W, Mistry, T, Nutland, S, Ovington, N, Schuilenburg, H, Simpson, A, Smink, L, Stevens, H, Taylor, N, Todd, J, Tuomilehto, J, Walker, N, Widmer, B, Wilson, M, Withers, H, Brown, M, Chen, WM, Crews, A, Griffin, J, Hall, M, Harnish, T, Hepler, J, Hilner, J, King, N, Lohman, K, Lu, L, Mychaleckyj, J, Nail, J, Perdue, L, Pierce, J, Reboussin, D, Rich, S, Rushing, S, Sale, M, Sides, E, Snively, B, Teuschler, H, Theil, G, Williams, D, Akolkar, B, McKeon, C, Nierras, C, Thomson, E, Altshuler, D, Au, K, Bain, S, Barcellos, L, Barral, S, Becker, T, Briggs, F, Bronson, P, Daly, M, de Bakker, P, Deloukas, P, Devlin, B, Eike, MC, Field, L, Gabriel, S, Garge, N, Gaudieri, S, Goldstein, B, Gorodezky, C, Hamon, S, He, C, Howson, J, Humphreys, K, James, I, Lathrop, M, Lie, BA, Li, D, Mack, S, McGinnis, R, McKinnon, E, McLaren, W, Nolan, D, Olsson, M, Ott, J, Owerbach, D, Patterson, C, Podolsky, R, Ramsay, P, Rangantah, V, Risch, N, Ronningen, KS, Shao, X, Single, R, Steffes, M, Thomson, G, Valdes, AM, Vandiedonck, C, Whittaker, P & Zhang, Q 2009, 'Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes', Nature Genetics, vol. 41, no. 6, pp. 703-707. https://doi.org/10.1038/ng.381
Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nature Genetics. 2009 Jun 1;41(6):703-707. https://doi.org/10.1038/ng.381
Barrett, J. C. ; Clayton, D. G. ; Concannon, P. ; Akolkar, B. ; Cooper, J. D. ; Erlich, H. A. ; Julier, C. ; Morahan, G. ; Nerup, J. ; Nierras, C. ; Plagnol, V. ; Pociot, F. ; Schuilenburg, H. ; Smyth, D. J. ; Stevens, H. ; Todd, J. A. ; Walker, N. M. ; Rich, S. S. ; Baskerville, T. ; Bautista, N. ; Bhatia, E. ; Bhatia, V. ; Bin Hasan, K. ; Bonnici, F. ; Brodnicki, T. ; Cameron, F. ; Chaichanwatanakul, K. ; Cheung, P. T. ; Colman, P. ; Cotterill, A. ; Couper, J. ; Cutfield, R. ; Davis, T. ; Dixon, P. ; Donaghue, K. ; Dowling, K. ; Drury, P. ; Dye, S. ; Gellert, S. ; Abdul Ghani, R. ; Greer, R. ; Han, X. ; Harrison, L. ; Homatopoulos, N. ; Ji, L. ; Jones, T. ; Yin, L. K. ; Kamaruddin, N. A. ; Kanga, U. ; Kanungo, A. ; Kaur, G. ; Kek, B. ; Knowles, S. ; Krebs, J. ; Kumar, N. ; Lee, Y. J. ; Li, X. ; Liktimaskul, S. ; Lloyd, M. ; Loth, A. ; Louey, A. ; Mehra, N. ; Merriman, T. ; Min, L. ; Morahan, G. ; Moses, R. ; Mraz, G. ; Murphy, R. ; Nicholson, I. ; Panelo, A. ; Poh, P. ; Price, G. ; Ratnam, N. ; Sanjeevi, C. ; Sedimbi, S. ; Shen, S. ; Ying, G. S. ; Tait, B. ; Tandon, N. ; Thomas, A. ; Varney, M. ; Weerakulwattana, P. ; Willis, J. ; Albret, L. ; Ampudia-Blasco, F. ; Argente, J. ; Babadjanova, G. ; Badenhoop, K. ; Battelino, T. ; Beilhack, G. ; Bergholdt, R. ; Bingley, P. ; Boehm, B. ; Bolidson, J. ; Brorsson, C. ; Carlson, J. ; Castano, L. ; Chandler, K. ; Cinek, O. ; Cipponeri, E. ; Corripio, R. ; Garcia Cuartero, B. ; de Leiva, A. ; Fagulha, A. ; Fernandez Balcells, M. ; Guja, C. ; Gutierrez, P. ; Hatziagelaki, E. ; Heath, S. ; Helmberg, W. ; Hernandez, M. ; Holzheu, I. ; Hosszufalusi, N. ; Ionescu-Tirgoviste, C. ; Johannesen, J. ; Julier, C. ; Kahles, H. ; Knip, M. ; Kockum, I. ; Kojo, E. ; Koprivarova, K. ; Kordonouri, O. ; Kretowski, A. ; Krikovszky, D. ; Kurkhaus, A. ; Lalic, N. ; Lavant, E. ; Long, A. ; Ludvigsson, J. ; Madacsy, L. ; Marga, M. ; Mauricio, D. ; Mazurkievicz, G. ; Nerup, J. ; Novoa Mogollon, F. J. ; Petersen, M. T. ; Phillip, M. ; Pirags, V. ; Pociot, F. ; Pozzilli, P. ; Rappner, R. ; Roep, B. ; Rokni, S. ; Rosinger, S. ; Rubio-Cabezas, O. ; Ruckgaber, C. ; Satman, I. ; Schober, E. ; Seufert, J. ; Sing, R. ; Skrha, J. ; Sobngwi, E. ; Somerville, M. ; Spinas, G. ; Tilmann, V. ; Undlien, D. ; Urbanavicius, V. ; Van der Auwera, B. ; Vasquez San Miguel, F. ; Vazeo-Gerasimidi, A. ; Velickiene, D. ; Wagner, A. ; Williams, A. ; Wurzburger, M. ; Ziegler, A. ; Agleham, M. ; Aldrich, A. ; Alemzadeh, R. ; Aly, T. ; Arora, S. ; Austin, A. ; Becker, D. ; Benoist, C. ; Berka, N. ; Bhatia, S. ; Bonella, P. ; Bottini, N. ; Boyle, S. ; Brady, B. ; Brickman, W. ; Christensen, R. ; Concannon, P. ; Couch, R. ; Counts, D. ; Crandall, J. ; Daniels, M. ; Dolan, L. ; Donaldson, D. ; Doria, A. ; Eisenbarth, G. ; El-Hajj, R. ; Erlich, H. ; Fain, P. ; Fear, A. L. ; Ferry, R. ; Fiallo-Scharer, R. ; Ghosh, S. ; Gitelman, S. ; Godwin, M. ; Goland, R. ; Goodman, N. ; Goodwin, G. ; Gravely, J. ; Greenbaum, C. ; Gudgeon, C. ; Gunville, F. ; Hagopian, W. ; Hakonarson, H. ; Hansen, J. ; Harrington, K. ; Hassing, J. ; Hilliker, W. ; Hoffman, R. ; Hulbert, E. ; Izquierdo, R. ; Jospe, N. ; Kaiserman, K. ; Kaufman, F. ; Kim, S. ; Kloos, E. ; Kosoy, R. ; Lane, J. ; Lane, J. ; Lawrence, J. ; Levetan, C. ; Levin, P. ; Lipton, R. ; Lonsdale, J. ; Magnuson, V. ; Marks, J. ; Mayer-Davis, B. ; McEvoy, R. ; McIndoe, Richard A ; Merkle, L. ; Metzger, D. ; Miao, D. ; Mickelson, E. ; Moonsamy, P. ; Moore, W. ; Moran, A. ; Noble, J. ; Olsem, G. ; Onengut-Gumuscu, S. ; Orban, T. ; Orlowski, C. ; Paterson, A. ; Pietropaolo, M. ; Pihoker, C. ; Polychronakos, C. ; Post, J. ; Postellon, D. ; Pugliese, A. ; Qu, H. ; Quattrin, T. ; Rappaport, M. ; Raskin, P. ; Risbeck, H. ; Rodriguez, H. ; Rodriguez, L. ; Rogers, M. ; Russell, B. ; Schatz, D. ; Scott, C. ; She, Jin-Xiong ; Shulman, D. ; Soyka, L. ; Speiser, P. ; Starkman, H. ; Steck, A. ; Stender, S. ; Stratton, L. ; Sur, D. ; Taback, S. ; Thrailkill, K. ; Toth, E. ; Trymbiski, P. ; Tsalikian, E. ; Vertachnik, K. ; Wahlen, J. ; Wang, X. ; Weber, S. ; Wherrett, D. ; Willi, S. ; Wilson, D. ; Youkey, J. ; Young, N. ; Yu, L. ; Zimmerman, D. ; Adlem, E. ; Allen, J. ; Brown, J. ; Burren, O. ; Clarke, P. ; Clayton, D. ; Coleman, G. ; Cooper, J. ; Cucca, Francesco ; Duley, S. ; Dunger, D. ; Everett, V. ; Hardy, M. ; Harrison, D. ; Harrison, I. ; Hawkins, S. ; Healy, B. ; Hood, S. ; Howell, S. ; Maisuria, M. ; Meadows, W. ; Mistry, T. ; Nutland, S. ; Ovington, N. ; Schuilenburg, H. ; Simpson, A. ; Smink, L. ; Stevens, H. ; Taylor, N. ; Todd, J. ; Tuomilehto, J. ; Walker, N. ; Widmer, B. ; Wilson, M. ; Withers, H. ; Brown, M. ; Chen, W. M. ; Crews, A. ; Griffin, J. ; Hall, M. ; Harnish, T. ; Hepler, J. ; Hilner, J. ; King, N. ; Lohman, K. ; Lu, L. ; Mychaleckyj, J. ; Nail, J. ; Perdue, L. ; Pierce, J. ; Reboussin, D. ; Rich, S. ; Rushing, S. ; Sale, M. ; Sides, E. ; Snively, B. ; Teuschler, H. ; Theil, G. ; Williams, D. ; Akolkar, B. ; McKeon, C. ; Nierras, C. ; Thomson, E. ; Altshuler, D. ; Au, K. ; Bain, S. ; Barcellos, L. ; Barral, S. ; Becker, T. ; Briggs, F. ; Bronson, P. ; Daly, M. ; de Bakker, P. ; Deloukas, P. ; Devlin, B. ; Eike, M. C. ; Field, L. ; Gabriel, S. ; Garge, N. ; Gaudieri, S. ; Goldstein, B. ; Gorodezky, C. ; Hamon, S. ; He, C. ; Howson, J. ; Humphreys, K. ; James, I. ; Lathrop, M. ; Lie, B. A. ; Li, D. ; Mack, S. ; McGinnis, R. ; McKinnon, E. ; McLaren, W. ; Nolan, D. ; Olsson, M. ; Ott, J. ; Owerbach, D. ; Patterson, C. ; Podolsky, R. ; Ramsay, P. ; Rangantah, V. ; Risch, N. ; Ronningen, K. S. ; Shao, X. ; Single, R. ; Steffes, M. ; Thomson, G. ; Valdes, A. M. ; Vandiedonck, C. ; Whittaker, P. ; Zhang, Q. / Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. In: Nature Genetics. 2009 ; Vol. 41, No. 6. pp. 703-707.
@article{216d2094ba184d90bcc514de3fed3ceb,
title = "Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes",
abstract = "Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P 10 6). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P 0.01; overall P 5 × 10 8) and 4 additional regions provided nominal evidence of replication (P 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.",
author = "Barrett, {J. C.} and Clayton, {D. G.} and P. Concannon and B. Akolkar and Cooper, {J. D.} and Erlich, {H. A.} and C. Julier and G. Morahan and J. Nerup and C. Nierras and V. Plagnol and F. Pociot and H. Schuilenburg and Smyth, {D. J.} and H. Stevens and Todd, {J. A.} and Walker, {N. M.} and Rich, {S. S.} and T. Baskerville and N. Bautista and E. Bhatia and V. Bhatia and {Bin Hasan}, K. and F. Bonnici and T. Brodnicki and F. Cameron and K. Chaichanwatanakul and Cheung, {P. T.} and P. Colman and A. Cotterill and J. Couper and R. Cutfield and T. Davis and P. Dixon and K. Donaghue and K. Dowling and P. Drury and S. Dye and S. Gellert and {Abdul Ghani}, R. and R. Greer and X. Han and L. Harrison and N. Homatopoulos and L. Ji and T. Jones and Yin, {L. K.} and Kamaruddin, {N. A.} and U. Kanga and A. Kanungo and G. Kaur and B. Kek and S. Knowles and J. Krebs and N. Kumar and Lee, {Y. J.} and X. Li and S. Liktimaskul and M. Lloyd and A. Loth and A. Louey and N. Mehra and T. Merriman and L. Min and G. Morahan and R. Moses and G. Mraz and R. Murphy and I. Nicholson and A. Panelo and P. Poh and G. Price and N. Ratnam and C. Sanjeevi and S. Sedimbi and S. Shen and Ying, {G. S.} and B. Tait and N. Tandon and A. Thomas and M. Varney and P. Weerakulwattana and J. Willis and L. Albret and F. Ampudia-Blasco and J. Argente and G. Babadjanova and K. Badenhoop and T. Battelino and G. Beilhack and R. Bergholdt and P. Bingley and B. Boehm and J. Bolidson and C. Brorsson and J. Carlson and L. Castano and K. Chandler and O. Cinek and E. Cipponeri and R. Corripio and {Garcia Cuartero}, B. and {de Leiva}, A. and A. Fagulha and {Fernandez Balcells}, M. and C. Guja and P. Gutierrez and E. Hatziagelaki and S. Heath and W. Helmberg and M. Hernandez and I. Holzheu and N. Hosszufalusi and C. Ionescu-Tirgoviste and J. Johannesen and C. Julier and H. Kahles and M. Knip and I. Kockum and E. Kojo and K. Koprivarova and O. Kordonouri and A. Kretowski and D. Krikovszky and A. Kurkhaus and N. Lalic and E. Lavant and A. Long and J. Ludvigsson and L. Madacsy and M. Marga and D. Mauricio and G. Mazurkievicz and J. Nerup and {Novoa Mogollon}, {F. J.} and Petersen, {M. T.} and M. Phillip and V. Pirags and F. Pociot and P. Pozzilli and R. Rappner and B. Roep and S. Rokni and S. Rosinger and O. Rubio-Cabezas and C. Ruckgaber and I. Satman and E. Schober and J. Seufert and R. Sing and J. Skrha and E. Sobngwi and M. Somerville and G. Spinas and V. Tilmann and D. Undlien and V. Urbanavicius and {Van der Auwera}, B. and {Vasquez San Miguel}, F. and A. Vazeo-Gerasimidi and D. Velickiene and A. Wagner and A. Williams and M. Wurzburger and A. Ziegler and M. Agleham and A. Aldrich and R. Alemzadeh and T. Aly and S. Arora and A. Austin and D. Becker and C. Benoist and N. Berka and S. Bhatia and P. Bonella and N. Bottini and S. Boyle and B. Brady and W. Brickman and R. Christensen and P. Concannon and R. Couch and D. Counts and J. Crandall and M. Daniels and L. Dolan and D. Donaldson and A. Doria and G. Eisenbarth and R. El-Hajj and H. Erlich and P. Fain and Fear, {A. L.} and R. Ferry and R. Fiallo-Scharer and S. Ghosh and S. Gitelman and M. Godwin and R. Goland and N. Goodman and G. Goodwin and J. Gravely and C. Greenbaum and C. Gudgeon and F. Gunville and W. Hagopian and H. Hakonarson and J. Hansen and K. Harrington and J. Hassing and W. Hilliker and R. Hoffman and E. Hulbert and R. Izquierdo and N. Jospe and K. Kaiserman and F. Kaufman and S. Kim and E. Kloos and R. Kosoy and J. Lane and J. Lane and J. Lawrence and C. Levetan and P. Levin and R. Lipton and J. Lonsdale and V. Magnuson and J. Marks and B. Mayer-Davis and R. McEvoy and McIndoe, {Richard A} and L. Merkle and D. Metzger and D. Miao and E. Mickelson and P. Moonsamy and W. Moore and A. Moran and J. Noble and G. Olsem and S. Onengut-Gumuscu and T. Orban and C. Orlowski and A. Paterson and M. Pietropaolo and C. Pihoker and C. Polychronakos and J. Post and D. Postellon and A. Pugliese and H. Qu and T. Quattrin and M. Rappaport and P. Raskin and H. Risbeck and H. Rodriguez and L. Rodriguez and M. Rogers and B. Russell and D. Schatz and C. Scott and Jin-Xiong She and D. Shulman and L. Soyka and P. Speiser and H. Starkman and A. Steck and S. Stender and L. Stratton and D. Sur and S. Taback and K. Thrailkill and E. Toth and P. Trymbiski and E. Tsalikian and K. Vertachnik and J. Wahlen and X. Wang and S. Weber and D. Wherrett and S. Willi and D. Wilson and J. Youkey and N. Young and L. Yu and D. Zimmerman and E. Adlem and J. Allen and J. Brown and O. Burren and P. Clarke and D. Clayton and G. Coleman and J. Cooper and Francesco Cucca and S. Duley and D. Dunger and V. Everett and M. Hardy and D. Harrison and I. Harrison and S. Hawkins and B. Healy and S. Hood and S. Howell and M. Maisuria and W. Meadows and T. Mistry and S. Nutland and N. Ovington and H. Schuilenburg and A. Simpson and L. Smink and H. Stevens and N. Taylor and J. Todd and J. Tuomilehto and N. Walker and B. Widmer and M. Wilson and H. Withers and M. Brown and Chen, {W. M.} and A. Crews and J. Griffin and M. Hall and T. Harnish and J. Hepler and J. Hilner and N. King and K. Lohman and L. Lu and J. Mychaleckyj and J. Nail and L. Perdue and J. Pierce and D. Reboussin and S. Rich and S. Rushing and M. Sale and E. Sides and B. Snively and H. Teuschler and G. Theil and D. Williams and B. Akolkar and C. McKeon and C. Nierras and E. Thomson and D. Altshuler and K. Au and S. Bain and L. Barcellos and S. Barral and T. Becker and F. Briggs and P. Bronson and M. Daly and {de Bakker}, P. and P. Deloukas and B. Devlin and Eike, {M. C.} and L. Field and S. Gabriel and N. Garge and S. Gaudieri and B. Goldstein and C. Gorodezky and S. Hamon and C. He and J. Howson and K. Humphreys and I. James and M. Lathrop and Lie, {B. A.} and D. Li and S. Mack and R. McGinnis and E. McKinnon and W. McLaren and D. Nolan and M. Olsson and J. Ott and D. Owerbach and C. Patterson and R. Podolsky and P. Ramsay and V. Rangantah and N. Risch and Ronningen, {K. S.} and X. Shao and R. Single and M. Steffes and G. Thomson and Valdes, {A. M.} and C. Vandiedonck and P. Whittaker and Q. Zhang",
year = "2009",
month = "6",
day = "1",
doi = "10.1038/ng.381",
language = "English (US)",
volume = "41",
pages = "703--707",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

AU - Barrett, J. C.

AU - Clayton, D. G.

AU - Concannon, P.

AU - Akolkar, B.

AU - Cooper, J. D.

AU - Erlich, H. A.

AU - Julier, C.

AU - Morahan, G.

AU - Nerup, J.

AU - Nierras, C.

AU - Plagnol, V.

AU - Pociot, F.

AU - Schuilenburg, H.

AU - Smyth, D. J.

AU - Stevens, H.

AU - Todd, J. A.

AU - Walker, N. M.

AU - Rich, S. S.

AU - Baskerville, T.

AU - Bautista, N.

AU - Bhatia, E.

AU - Bhatia, V.

AU - Bin Hasan, K.

AU - Bonnici, F.

AU - Brodnicki, T.

AU - Cameron, F.

AU - Chaichanwatanakul, K.

AU - Cheung, P. T.

AU - Colman, P.

AU - Cotterill, A.

AU - Couper, J.

AU - Cutfield, R.

AU - Davis, T.

AU - Dixon, P.

AU - Donaghue, K.

AU - Dowling, K.

AU - Drury, P.

AU - Dye, S.

AU - Gellert, S.

AU - Abdul Ghani, R.

AU - Greer, R.

AU - Han, X.

AU - Harrison, L.

AU - Homatopoulos, N.

AU - Ji, L.

AU - Jones, T.

AU - Yin, L. K.

AU - Kamaruddin, N. A.

AU - Kanga, U.

AU - Kanungo, A.

AU - Kaur, G.

AU - Kek, B.

AU - Knowles, S.

AU - Krebs, J.

AU - Kumar, N.

AU - Lee, Y. J.

AU - Li, X.

AU - Liktimaskul, S.

AU - Lloyd, M.

AU - Loth, A.

AU - Louey, A.

AU - Mehra, N.

AU - Merriman, T.

AU - Min, L.

AU - Morahan, G.

AU - Moses, R.

AU - Mraz, G.

AU - Murphy, R.

AU - Nicholson, I.

AU - Panelo, A.

AU - Poh, P.

AU - Price, G.

AU - Ratnam, N.

AU - Sanjeevi, C.

AU - Sedimbi, S.

AU - Shen, S.

AU - Ying, G. S.

AU - Tait, B.

AU - Tandon, N.

AU - Thomas, A.

AU - Varney, M.

AU - Weerakulwattana, P.

AU - Willis, J.

AU - Albret, L.

AU - Ampudia-Blasco, F.

AU - Argente, J.

AU - Babadjanova, G.

AU - Badenhoop, K.

AU - Battelino, T.

AU - Beilhack, G.

AU - Bergholdt, R.

AU - Bingley, P.

AU - Boehm, B.

AU - Bolidson, J.

AU - Brorsson, C.

AU - Carlson, J.

AU - Castano, L.

AU - Chandler, K.

AU - Cinek, O.

AU - Cipponeri, E.

AU - Corripio, R.

AU - Garcia Cuartero, B.

AU - de Leiva, A.

AU - Fagulha, A.

AU - Fernandez Balcells, M.

AU - Guja, C.

AU - Gutierrez, P.

AU - Hatziagelaki, E.

AU - Heath, S.

AU - Helmberg, W.

AU - Hernandez, M.

AU - Holzheu, I.

AU - Hosszufalusi, N.

AU - Ionescu-Tirgoviste, C.

AU - Johannesen, J.

AU - Julier, C.

AU - Kahles, H.

AU - Knip, M.

AU - Kockum, I.

AU - Kojo, E.

AU - Koprivarova, K.

AU - Kordonouri, O.

AU - Kretowski, A.

AU - Krikovszky, D.

AU - Kurkhaus, A.

AU - Lalic, N.

AU - Lavant, E.

AU - Long, A.

AU - Ludvigsson, J.

AU - Madacsy, L.

AU - Marga, M.

AU - Mauricio, D.

AU - Mazurkievicz, G.

AU - Nerup, J.

AU - Novoa Mogollon, F. J.

AU - Petersen, M. T.

AU - Phillip, M.

AU - Pirags, V.

AU - Pociot, F.

AU - Pozzilli, P.

AU - Rappner, R.

AU - Roep, B.

AU - Rokni, S.

AU - Rosinger, S.

AU - Rubio-Cabezas, O.

AU - Ruckgaber, C.

AU - Satman, I.

AU - Schober, E.

AU - Seufert, J.

AU - Sing, R.

AU - Skrha, J.

AU - Sobngwi, E.

AU - Somerville, M.

AU - Spinas, G.

AU - Tilmann, V.

AU - Undlien, D.

AU - Urbanavicius, V.

AU - Van der Auwera, B.

AU - Vasquez San Miguel, F.

AU - Vazeo-Gerasimidi, A.

AU - Velickiene, D.

AU - Wagner, A.

AU - Williams, A.

AU - Wurzburger, M.

AU - Ziegler, A.

AU - Agleham, M.

AU - Aldrich, A.

AU - Alemzadeh, R.

AU - Aly, T.

AU - Arora, S.

AU - Austin, A.

AU - Becker, D.

AU - Benoist, C.

AU - Berka, N.

AU - Bhatia, S.

AU - Bonella, P.

AU - Bottini, N.

AU - Boyle, S.

AU - Brady, B.

AU - Brickman, W.

AU - Christensen, R.

AU - Concannon, P.

AU - Couch, R.

AU - Counts, D.

AU - Crandall, J.

AU - Daniels, M.

AU - Dolan, L.

AU - Donaldson, D.

AU - Doria, A.

AU - Eisenbarth, G.

AU - El-Hajj, R.

AU - Erlich, H.

AU - Fain, P.

AU - Fear, A. L.

AU - Ferry, R.

AU - Fiallo-Scharer, R.

AU - Ghosh, S.

AU - Gitelman, S.

AU - Godwin, M.

AU - Goland, R.

AU - Goodman, N.

AU - Goodwin, G.

AU - Gravely, J.

AU - Greenbaum, C.

AU - Gudgeon, C.

AU - Gunville, F.

AU - Hagopian, W.

AU - Hakonarson, H.

AU - Hansen, J.

AU - Harrington, K.

AU - Hassing, J.

AU - Hilliker, W.

AU - Hoffman, R.

AU - Hulbert, E.

AU - Izquierdo, R.

AU - Jospe, N.

AU - Kaiserman, K.

AU - Kaufman, F.

AU - Kim, S.

AU - Kloos, E.

AU - Kosoy, R.

AU - Lane, J.

AU - Lane, J.

AU - Lawrence, J.

AU - Levetan, C.

AU - Levin, P.

AU - Lipton, R.

AU - Lonsdale, J.

AU - Magnuson, V.

AU - Marks, J.

AU - Mayer-Davis, B.

AU - McEvoy, R.

AU - McIndoe, Richard A

AU - Merkle, L.

AU - Metzger, D.

AU - Miao, D.

AU - Mickelson, E.

AU - Moonsamy, P.

AU - Moore, W.

AU - Moran, A.

AU - Noble, J.

AU - Olsem, G.

AU - Onengut-Gumuscu, S.

AU - Orban, T.

AU - Orlowski, C.

AU - Paterson, A.

AU - Pietropaolo, M.

AU - Pihoker, C.

AU - Polychronakos, C.

AU - Post, J.

AU - Postellon, D.

AU - Pugliese, A.

AU - Qu, H.

AU - Quattrin, T.

AU - Rappaport, M.

AU - Raskin, P.

AU - Risbeck, H.

AU - Rodriguez, H.

AU - Rodriguez, L.

AU - Rogers, M.

AU - Russell, B.

AU - Schatz, D.

AU - Scott, C.

AU - She, Jin-Xiong

AU - Shulman, D.

AU - Soyka, L.

AU - Speiser, P.

AU - Starkman, H.

AU - Steck, A.

AU - Stender, S.

AU - Stratton, L.

AU - Sur, D.

AU - Taback, S.

AU - Thrailkill, K.

AU - Toth, E.

AU - Trymbiski, P.

AU - Tsalikian, E.

AU - Vertachnik, K.

AU - Wahlen, J.

AU - Wang, X.

AU - Weber, S.

AU - Wherrett, D.

AU - Willi, S.

AU - Wilson, D.

AU - Youkey, J.

AU - Young, N.

AU - Yu, L.

AU - Zimmerman, D.

AU - Adlem, E.

AU - Allen, J.

AU - Brown, J.

AU - Burren, O.

AU - Clarke, P.

AU - Clayton, D.

AU - Coleman, G.

AU - Cooper, J.

AU - Cucca, Francesco

AU - Duley, S.

AU - Dunger, D.

AU - Everett, V.

AU - Hardy, M.

AU - Harrison, D.

AU - Harrison, I.

AU - Hawkins, S.

AU - Healy, B.

AU - Hood, S.

AU - Howell, S.

AU - Maisuria, M.

AU - Meadows, W.

AU - Mistry, T.

AU - Nutland, S.

AU - Ovington, N.

AU - Schuilenburg, H.

AU - Simpson, A.

AU - Smink, L.

AU - Stevens, H.

AU - Taylor, N.

AU - Todd, J.

AU - Tuomilehto, J.

AU - Walker, N.

AU - Widmer, B.

AU - Wilson, M.

AU - Withers, H.

AU - Brown, M.

AU - Chen, W. M.

AU - Crews, A.

AU - Griffin, J.

AU - Hall, M.

AU - Harnish, T.

AU - Hepler, J.

AU - Hilner, J.

AU - King, N.

AU - Lohman, K.

AU - Lu, L.

AU - Mychaleckyj, J.

AU - Nail, J.

AU - Perdue, L.

AU - Pierce, J.

AU - Reboussin, D.

AU - Rich, S.

AU - Rushing, S.

AU - Sale, M.

AU - Sides, E.

AU - Snively, B.

AU - Teuschler, H.

AU - Theil, G.

AU - Williams, D.

AU - Akolkar, B.

AU - McKeon, C.

AU - Nierras, C.

AU - Thomson, E.

AU - Altshuler, D.

AU - Au, K.

AU - Bain, S.

AU - Barcellos, L.

AU - Barral, S.

AU - Becker, T.

AU - Briggs, F.

AU - Bronson, P.

AU - Daly, M.

AU - de Bakker, P.

AU - Deloukas, P.

AU - Devlin, B.

AU - Eike, M. C.

AU - Field, L.

AU - Gabriel, S.

AU - Garge, N.

AU - Gaudieri, S.

AU - Goldstein, B.

AU - Gorodezky, C.

AU - Hamon, S.

AU - He, C.

AU - Howson, J.

AU - Humphreys, K.

AU - James, I.

AU - Lathrop, M.

AU - Lie, B. A.

AU - Li, D.

AU - Mack, S.

AU - McGinnis, R.

AU - McKinnon, E.

AU - McLaren, W.

AU - Nolan, D.

AU - Olsson, M.

AU - Ott, J.

AU - Owerbach, D.

AU - Patterson, C.

AU - Podolsky, R.

AU - Ramsay, P.

AU - Rangantah, V.

AU - Risch, N.

AU - Ronningen, K. S.

AU - Shao, X.

AU - Single, R.

AU - Steffes, M.

AU - Thomson, G.

AU - Valdes, A. M.

AU - Vandiedonck, C.

AU - Whittaker, P.

AU - Zhang, Q.

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P 10 6). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P 0.01; overall P 5 × 10 8) and 4 additional regions provided nominal evidence of replication (P 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.

AB - Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P 10 6). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P 0.01; overall P 5 × 10 8) and 4 additional regions provided nominal evidence of replication (P 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.

UR - http://www.scopus.com/inward/record.url?scp=67349199566&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349199566&partnerID=8YFLogxK

U2 - 10.1038/ng.381

DO - 10.1038/ng.381

M3 - Article

VL - 41

SP - 703

EP - 707

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 6

ER -

Access to Document