Genomic Diversity of Type B3 Bacteriophages of Caulobacter crescentus

Kurt T. Ash, Kristina M. Drake, Whitney S. Gibbs, Bert Ely

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The genomes of the type B3 bacteriophages that infect Caulobacter crescentus are among the largest phage genomes thus far deposited into GenBank with sizes over 200 kb. In this study, we introduce six new bacteriophage genomes which were obtained from phage collected from various water systems in the southeastern United States and from tropical locations across the globe. A comparative analysis of the 12 available genomes revealed a “core genome” which accounts for roughly 1/3 of these bacteriophage genomes and is predominately localized to the head, tail, and lysis gene regions. Despite being isolated from geographically distinct locations, the genomes of these bacteriophages are highly conserved in both genome sequence and gene order. We also identified the insertions, deletions, translocations, and horizontal gene transfer events which are responsible for the genomic diversity of this group of bacteriophages and demonstrated that these changes are not consistent with the idea that modular reassortment of genomes occurs in this group of bacteriophages.

Original languageEnglish (US)
Pages (from-to)779-786
Number of pages8
JournalCurrent Microbiology
Volume74
Issue number7
DOIs
StatePublished - Jul 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

Fingerprint

Dive into the research topics of 'Genomic Diversity of Type B3 Bacteriophages of Caulobacter crescentus'. Together they form a unique fingerprint.

Cite this