Abstract
Context: Women with polycystic ovary syndrome (PCOS) have increased risk for pregnancy complications, possibly related to pre-existing obesity and excessive gestational weight gain (GWG). Objectives: To assess the contributions of diagnosis and preconception weight on GWG and perinatal outcomes. Research Design and Methods: Prospective cohort study of singleton pregnancies in PCOS (n = 164) and ovulatory controls (n = 176) from infertility treatment. Main Outcome Measures: GWG, birthweight, pregnancy complications. Results: From preconception baseline, normal-weight women with PCOS gained 2.3 pounds more during the first trimester (95% CI, 0.3 to 4.3; P = 0.02), and by the end of the second trimester, 4.2 pounds more than controls (95% CI, 0.7 to 7.7; P = 0.02). Women who were overweight with PCOS gained significantly more weight than did controls by the end of the second trimester (5.2 pounds; 95% CI, 0.2 to 10.2; P = 0.04), whereas women with obesity and PCOS and control women had similar weight gain throughout pregnancy. Within normal-weight, overweight, and obese groups, prevalence of pre-eclampsia and gestational diabetes did not differ between the PCOS and control groups, nor was there a difference in birthweight. Preconception body mass index (BMI) was significantly associated with GWG; for every 1-kg/m 2 increase in preconception BMI, GWG decreased by 0.62 pounds (95% CI, 20.85 to 20.40; P, 0.001). Conclusions: Women with PCOS who are of normal weight or are overweight before conception experience more GWG than do ovulatory controls. Within normal-weight, overweight, and obese groups, rates of perinatal complications do not significantly differ between women with PCOS and controls. Preconception BMI is the strongest predictor of GWG.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4315-4323 |
| Number of pages | 9 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 103 |
| Issue number | 11 |
| DOIs | |
| State | Published - Jan 1 2018 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Endocrinology
- Clinical Biochemistry
- Biochemistry, medical
Cite this
Gestational weight gain in women with polycystic ovary syndrome : A controlled study. / Kent, James; Dodson, William C.; Kunselman, Allen; Pauli, Jaimey; Stone, Alicia; Diamond, Michael Peter; Coutifaris, Christos; Schlaff, William D.; Alvero, Ruben; Casson, Peter; Christman, Gregory M.; Rosen, R. Mitchell; Hansen, Karl R.; Robinson, Randall D.; Baker, Valerie; Usadi, Rebecca; Santoro, Nanette; Zhang, Heping; Eisenberg, Esther; Legro, Richard S.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 103, No. 11, 01.01.2018, p. 4315-4323.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gestational weight gain in women with polycystic ovary syndrome
T2 - A controlled study
AU - Kent, James
AU - Dodson, William C.
AU - Kunselman, Allen
AU - Pauli, Jaimey
AU - Stone, Alicia
AU - Diamond, Michael Peter
AU - Coutifaris, Christos
AU - Schlaff, William D.
AU - Alvero, Ruben
AU - Casson, Peter
AU - Christman, Gregory M.
AU - Rosen, R. Mitchell
AU - Hansen, Karl R.
AU - Robinson, Randall D.
AU - Baker, Valerie
AU - Usadi, Rebecca
AU - Santoro, Nanette
AU - Zhang, Heping
AU - Eisenberg, Esther
AU - Legro, Richard S.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Context: Women with polycystic ovary syndrome (PCOS) have increased risk for pregnancy complications, possibly related to pre-existing obesity and excessive gestational weight gain (GWG). Objectives: To assess the contributions of diagnosis and preconception weight on GWG and perinatal outcomes. Research Design and Methods: Prospective cohort study of singleton pregnancies in PCOS (n = 164) and ovulatory controls (n = 176) from infertility treatment. Main Outcome Measures: GWG, birthweight, pregnancy complications. Results: From preconception baseline, normal-weight women with PCOS gained 2.3 pounds more during the first trimester (95% CI, 0.3 to 4.3; P = 0.02), and by the end of the second trimester, 4.2 pounds more than controls (95% CI, 0.7 to 7.7; P = 0.02). Women who were overweight with PCOS gained significantly more weight than did controls by the end of the second trimester (5.2 pounds; 95% CI, 0.2 to 10.2; P = 0.04), whereas women with obesity and PCOS and control women had similar weight gain throughout pregnancy. Within normal-weight, overweight, and obese groups, prevalence of pre-eclampsia and gestational diabetes did not differ between the PCOS and control groups, nor was there a difference in birthweight. Preconception body mass index (BMI) was significantly associated with GWG; for every 1-kg/m 2 increase in preconception BMI, GWG decreased by 0.62 pounds (95% CI, 20.85 to 20.40; P, 0.001). Conclusions: Women with PCOS who are of normal weight or are overweight before conception experience more GWG than do ovulatory controls. Within normal-weight, overweight, and obese groups, rates of perinatal complications do not significantly differ between women with PCOS and controls. Preconception BMI is the strongest predictor of GWG.
AB - Context: Women with polycystic ovary syndrome (PCOS) have increased risk for pregnancy complications, possibly related to pre-existing obesity and excessive gestational weight gain (GWG). Objectives: To assess the contributions of diagnosis and preconception weight on GWG and perinatal outcomes. Research Design and Methods: Prospective cohort study of singleton pregnancies in PCOS (n = 164) and ovulatory controls (n = 176) from infertility treatment. Main Outcome Measures: GWG, birthweight, pregnancy complications. Results: From preconception baseline, normal-weight women with PCOS gained 2.3 pounds more during the first trimester (95% CI, 0.3 to 4.3; P = 0.02), and by the end of the second trimester, 4.2 pounds more than controls (95% CI, 0.7 to 7.7; P = 0.02). Women who were overweight with PCOS gained significantly more weight than did controls by the end of the second trimester (5.2 pounds; 95% CI, 0.2 to 10.2; P = 0.04), whereas women with obesity and PCOS and control women had similar weight gain throughout pregnancy. Within normal-weight, overweight, and obese groups, prevalence of pre-eclampsia and gestational diabetes did not differ between the PCOS and control groups, nor was there a difference in birthweight. Preconception body mass index (BMI) was significantly associated with GWG; for every 1-kg/m 2 increase in preconception BMI, GWG decreased by 0.62 pounds (95% CI, 20.85 to 20.40; P, 0.001). Conclusions: Women with PCOS who are of normal weight or are overweight before conception experience more GWG than do ovulatory controls. Within normal-weight, overweight, and obese groups, rates of perinatal complications do not significantly differ between women with PCOS and controls. Preconception BMI is the strongest predictor of GWG.
UR - http://www.scopus.com/inward/record.url?scp=85055073191&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055073191&partnerID=8YFLogxK
U2 - 10.1210/jc.2017-02764
DO - 10.1210/jc.2017-02764
M3 - Article
C2 - 30085187
AN - SCOPUS:85055073191
VL - 103
SP - 4315
EP - 4323
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 11
ER -