Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990-2017

Simon Yadgir, Catherine Owens Johnson, Victor Aboyans, Oladimeji M. Adebayo, Rufus Adesoji Adedoyin, Mohsen Afarideh, Fares Alahdab, Alaa Alashi, Vahid Alipour, Jalal Arabloo, Samad Azari, Celine M. Barthelemy, Catherine P. Benziger, Adam E. Berman, Ali Bijani, Juan J. Carrero, Félix Carvalho, Ahmad Daryani, Andre R. Durães, Alireza EsteghamatiTalha A. Farid, Farshad Farzadfar, Eduarda Fernandes, Irina Filip, Mohamed M. Gad, Samer Hamidi, Simon I. Hay, Olayinka Stephen Ilesanmi, Seyed Sina Naghibi Irvani, Mikk Jürisson, Amir Kasaeian, Andre Pascal Kengne, Abdur Rahman Khan, Adnan Kisa, Sezer Kisa, Dhaval Kolte, Navid Manafi, Amir Manafi, George A. Mensah, Erkin M. Mirrakhimov, Yousef Mohammad, Ali H. Mokdad, Ruxandra Irina Negoi, Huong Lan Thi Nguyen, Trang Huyen Nguyen, Molly R. Nixon, Catherine M. Otto, Shanti Patel, Thomas Pilgrim, Amir Radfar, David Laith Rawaf, Salman Rawaf, Wasiq Faraz Rawasia, Aziz Rezapour, Leonardo Roever, Anas M. Saad, Seyedmohammad Saadatagah, Subramanian Senthilkumaran, Karen Sliwa, Berhe Etsay Tesfay, Bach Xuan Tran, Irfan Ullah, Muthiah Vaduganathan, Tommi Juhani Vasankari, Charles D.A. Wolfe, Naohiro Yonemoto, Gregory A. Roth

Research output: Contribution to journalReview articlepeer-review

119 Scopus citations


Background: Nonrheumatic valvular diseases are common; however, no studies have estimated their global or national burden. As part of the Global Burden of Disease Study 2017, mortality, prevalence, and disability-adjusted life-years (DALYs) for calcific aortic valve disease (CAVD), degenerative mitral valve disease, and other nonrheumatic valvular diseases were estimated for 195 countries and territories from 1990 to 2017. Methods: Vital registration data, epidemiologic survey data, and administrative hospital data were used to estimate disease burden using the Global Burden of Disease Study modeling framework, which ensures comparability across locations. Geospatial statistical methods were used to estimate disease for all countries, because data on nonrheumatic valvular diseases are extremely limited for some regions of the world, such as Sub-Saharan Africa and South Asia. Results accounted for estimated level of disease severity as well as the estimated availability of valve repair or replacement procedures. DALYs and other measures of health-related burden were generated for both sexes and each 5-year age group, location, and year from 1990 to 2017. Results: Globally, CAVD and degenerative mitral valve disease caused 102 700 (95% uncertainty interval [UI], 82 700-107 900) and 35 700 (95% UI, 30 500-42 500) deaths, and 12.6 million (95% UI, 11.4 million-13.8 million) and 18.1 million (95% UI, 17.6 million-18.6 million) prevalent cases existed in 2017, respectively. A total of 2.5 million (95% UI, 2.3 million-2.8 million) DALYs were estimated as caused by nonrheumatic valvular diseases globally, representing 0.10% (95% UI, 0.09%-0.11%) of total lost health from all diseases in 2017. The number of DALYs increased for CAVD and degenerative mitral valve disease between 1990 and 2017 by 101% (95% UI, 79%-117%) and 35% (95% UI, 23%-47%), respectively. There is significant geographic variation in the prevalence, mortality rate, and overall burden of these diseases, with highest age-standardized DALY rates of CAVD estimated for high-income countries. Conclusions: These global and national estimates demonstrate that CAVD and degenerative mitral valve disease are important causes of disease burden among older adults. Efforts to clarify modifiable risk factors and improve access to valve interventions are necessary if progress is to be made toward reducing, and eventually eliminating, the burden of these highly treatable diseases.

Original languageEnglish (US)
Pages (from-to)1670-1680
Number of pages11
StatePublished - May 26 2020
Externally publishedYes


  • aortic valve
  • global burden of disease
  • heart valve diseases
  • mitral valve

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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