Glutamate: A major neuroendocrine excitatory signal mediating steroid effects on gonadotropin secretion

Darrell W Brann, Virendra B. Mahesh

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The preovulatory gonadotropin surge is induced by progesterone in the cycling female rat or in the ovariectomized estrogen-treated female rat after adequate estrogen-priming activity is present. The source of progesterone under physiological conditions could be the ovary and/or the adrenal. Since the GnRH neuron does not possess estrogen and progesterone receptors, its function is modulated by other CNS neurotransmitters and neurosecretory products. Among these, excitatory amino acids (EAAs) have now been shown to play an important role in the regulation of pulsatile gonadotropin release, induction of puberty and preovulatory and steroid-induced gonadotropin surges. Glutamate, the major endogenous EAA exerts its action through ionotropic and metabotropic receptors. The ionotropic receptors consist of two major classes, the NMDA (N-methyl-D-aspartate) and non-NMDA: kainate and AMPA (dl-α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors. EAA receptors are found in hypothalamic areas involved with reproduction. While both NMDA and non-NMDA receptors are involved in the regulation of LH secretion, the NMDA receptors appear to be involved with the regulation of puberty and FSH secretion as well. Steroids increase the release rates of glutamate and aspartate in the preoptic area during the gonadotropin surge. Steroids may also regulate the hypothalamic AMPA receptors.

Original languageEnglish (US)
Pages (from-to)325-329
Number of pages5
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume53
Issue number1-6
DOIs
StatePublished - Jan 1 1995

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Gonadotropins
Glutamic Acid
Steroids
D-Aspartic Acid
Excitatory Amino Acids
N-Methylaspartate
Puberty
Progesterone
Rats
Estrogens
Isoxazoles
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Preoptic Area
AMPA Receptors
Kainic Acid
Glutamate Receptors
Progesterone Receptors
N-Methyl-D-Aspartate Receptors
Aspartic Acid
Gonadotropin-Releasing Hormone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Glutamate : A major neuroendocrine excitatory signal mediating steroid effects on gonadotropin secretion. / Brann, Darrell W; Mahesh, Virendra B.

In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 53, No. 1-6, 01.01.1995, p. 325-329.

Research output: Contribution to journalArticle

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