Gonadal dysgenesis with ovarian function: Clinical and cytogenetic findings in six patients

Paul G McDonough, J. Rogers Byrd, Murray A. Freedman

Research output: Contribution to journalArticle

7 Scopus citations


In six patients with gonadal dysgenesis, ovarian function was evidenced by menses, which persisted in one patient for as long as seven years after the onset of menarche. Three patients had abnormal sex chromosome karyotypes in peripheral blood. Four subjects, with leukocyte cultures of 45/XO, 46/XX, 46/XX and 46/XX, respectively, had similar karyotypes in skin biopsy material. Those patients with abnormal sex chromosomal complements tended to be somewhat shorter in stature. No correlations could be seen between the sex idiogram and the duration of ovarian activity. The importance of considering gonadal dysgenesis as a differential diagnosis in all patients with secondary amenorrhea, especially when the menstrual life has been brief, is stressed.

Original languageEnglish (US)
Pages (from-to)868-872
Number of pages5
JournalObstetrics and Gynecology
Issue number6
Publication statusPublished - Jan 1 1971


ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this