Gonadal dysgenesis with ovarian function

Clinical and cytogenetic findings in six patients

Paul G McDonough, J. Rogers Byrd, Murray A. Freedman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In six patients with gonadal dysgenesis, ovarian function was evidenced by menses, which persisted in one patient for as long as seven years after the onset of menarche. Three patients had abnormal sex chromosome karyotypes in peripheral blood. Four subjects, with leukocyte cultures of 45/XO, 46/XX, 46/XX and 46/XX, respectively, had similar karyotypes in skin biopsy material. Those patients with abnormal sex chromosomal complements tended to be somewhat shorter in stature. No correlations could be seen between the sex idiogram and the duration of ovarian activity. The importance of considering gonadal dysgenesis as a differential diagnosis in all patients with secondary amenorrhea, especially when the menstrual life has been brief, is stressed.

Original languageEnglish (US)
Pages (from-to)868-872
Number of pages5
JournalObstetrics and Gynecology
Volume37
Issue number6
StatePublished - Jan 1 1971

Fingerprint

Gonadal Dysgenesis
Cytogenetics
Karyotype
Sex Chromosomes
Menarche
Menstruation
Amenorrhea
Leukocytes
Differential Diagnosis
Biopsy
Skin

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Gonadal dysgenesis with ovarian function : Clinical and cytogenetic findings in six patients. / McDonough, Paul G; Byrd, J. Rogers; Freedman, Murray A.

In: Obstetrics and Gynecology, Vol. 37, No. 6, 01.01.1971, p. 868-872.

Research output: Contribution to journalArticle

McDonough, PG, Byrd, JR & Freedman, MA 1971, 'Gonadal dysgenesis with ovarian function: Clinical and cytogenetic findings in six patients', Obstetrics and Gynecology, vol. 37, no. 6, pp. 868-872.
McDonough, Paul G ; Byrd, J. Rogers ; Freedman, Murray A. / Gonadal dysgenesis with ovarian function : Clinical and cytogenetic findings in six patients. In: Obstetrics and Gynecology. 1971 ; Vol. 37, No. 6. pp. 868-872.
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