Heat shock proteins, thermotolerance, and their relevance to clinical hyperthermia

G. C. Li, Nahid F Mivechi, G. Weitzel

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

Mammalian cells, when exposed to a non-lethal heat shock, have the ability to acquire a transient resistance to subsequent exposures at elevated temperatures, a phenomenon termed thermotolerance. The mechanism(s) for the development of thermotolerance is not well understood, but earlier experimental evidence suggests that protein synthesis may play a role in its manifestation. On the molecular level, heat shock activates a specific set of genes, so-called heat shock genes, and results in the preferential synthesis of heat shock proteins. The heat shock response, specifically the regulation, expression and functions of heat shock proteins, has been extensively studied in the past decades and has attracted the attention of a wide spectrum of investigators ranging from molecular and cell biologists to radiation and hyperthermia oncologists. There is much data supporting the hypothesis that heat shock proteins play important roles in modulating cellular responses to heat shock, and are involved in the development of thermotolerance. This review summarizes some current knowledge on thermotolerance and the functions of heat shock proteins, especially hsp70. The relationship between thermotolerance development and hsp70 synthesis in tumours and in normal tissues is examined. The possibility of using hsp70 as an indicator for thermotolerance is discussed.

Original languageEnglish (US)
Pages (from-to)459-488
Number of pages30
JournalInternational Journal of Hyperthermia
Volume11
Issue number4
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Heat-Shock Proteins
Fever
Heat-Shock Response
Shock
Hot Temperature
Genes
Thermotolerance
Research Personnel
Temperature
Neoplasms
Proteins

Keywords

  • Clinical hyperthermia
  • Heat shock protein
  • Normal tissues
  • Thermotolerance
  • Tumours

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cancer Research

Cite this

Heat shock proteins, thermotolerance, and their relevance to clinical hyperthermia. / Li, G. C.; Mivechi, Nahid F; Weitzel, G.

In: International Journal of Hyperthermia, Vol. 11, No. 4, 01.01.1995, p. 459-488.

Research output: Contribution to journalArticle

@article{4f37103f366d4fc2a9f044dc8361ebfb,
title = "Heat shock proteins, thermotolerance, and their relevance to clinical hyperthermia",
abstract = "Mammalian cells, when exposed to a non-lethal heat shock, have the ability to acquire a transient resistance to subsequent exposures at elevated temperatures, a phenomenon termed thermotolerance. The mechanism(s) for the development of thermotolerance is not well understood, but earlier experimental evidence suggests that protein synthesis may play a role in its manifestation. On the molecular level, heat shock activates a specific set of genes, so-called heat shock genes, and results in the preferential synthesis of heat shock proteins. The heat shock response, specifically the regulation, expression and functions of heat shock proteins, has been extensively studied in the past decades and has attracted the attention of a wide spectrum of investigators ranging from molecular and cell biologists to radiation and hyperthermia oncologists. There is much data supporting the hypothesis that heat shock proteins play important roles in modulating cellular responses to heat shock, and are involved in the development of thermotolerance. This review summarizes some current knowledge on thermotolerance and the functions of heat shock proteins, especially hsp70. The relationship between thermotolerance development and hsp70 synthesis in tumours and in normal tissues is examined. The possibility of using hsp70 as an indicator for thermotolerance is discussed.",
keywords = "Clinical hyperthermia, Heat shock protein, Normal tissues, Thermotolerance, Tumours",
author = "Li, {G. C.} and Mivechi, {Nahid F} and G. Weitzel",
year = "1995",
month = "1",
day = "1",
doi = "10.3109/02656739509022483",
language = "English (US)",
volume = "11",
pages = "459--488",
journal = "International Journal of Hyperthermia",
issn = "0265-6736",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Heat shock proteins, thermotolerance, and their relevance to clinical hyperthermia

AU - Li, G. C.

AU - Mivechi, Nahid F

AU - Weitzel, G.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Mammalian cells, when exposed to a non-lethal heat shock, have the ability to acquire a transient resistance to subsequent exposures at elevated temperatures, a phenomenon termed thermotolerance. The mechanism(s) for the development of thermotolerance is not well understood, but earlier experimental evidence suggests that protein synthesis may play a role in its manifestation. On the molecular level, heat shock activates a specific set of genes, so-called heat shock genes, and results in the preferential synthesis of heat shock proteins. The heat shock response, specifically the regulation, expression and functions of heat shock proteins, has been extensively studied in the past decades and has attracted the attention of a wide spectrum of investigators ranging from molecular and cell biologists to radiation and hyperthermia oncologists. There is much data supporting the hypothesis that heat shock proteins play important roles in modulating cellular responses to heat shock, and are involved in the development of thermotolerance. This review summarizes some current knowledge on thermotolerance and the functions of heat shock proteins, especially hsp70. The relationship between thermotolerance development and hsp70 synthesis in tumours and in normal tissues is examined. The possibility of using hsp70 as an indicator for thermotolerance is discussed.

AB - Mammalian cells, when exposed to a non-lethal heat shock, have the ability to acquire a transient resistance to subsequent exposures at elevated temperatures, a phenomenon termed thermotolerance. The mechanism(s) for the development of thermotolerance is not well understood, but earlier experimental evidence suggests that protein synthesis may play a role in its manifestation. On the molecular level, heat shock activates a specific set of genes, so-called heat shock genes, and results in the preferential synthesis of heat shock proteins. The heat shock response, specifically the regulation, expression and functions of heat shock proteins, has been extensively studied in the past decades and has attracted the attention of a wide spectrum of investigators ranging from molecular and cell biologists to radiation and hyperthermia oncologists. There is much data supporting the hypothesis that heat shock proteins play important roles in modulating cellular responses to heat shock, and are involved in the development of thermotolerance. This review summarizes some current knowledge on thermotolerance and the functions of heat shock proteins, especially hsp70. The relationship between thermotolerance development and hsp70 synthesis in tumours and in normal tissues is examined. The possibility of using hsp70 as an indicator for thermotolerance is discussed.

KW - Clinical hyperthermia

KW - Heat shock protein

KW - Normal tissues

KW - Thermotolerance

KW - Tumours

UR - http://www.scopus.com/inward/record.url?scp=0029031941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029031941&partnerID=8YFLogxK

U2 - 10.3109/02656739509022483

DO - 10.3109/02656739509022483

M3 - Article

C2 - 7594802

AN - SCOPUS:0029031941

VL - 11

SP - 459

EP - 488

JO - International Journal of Hyperthermia

JF - International Journal of Hyperthermia

SN - 0265-6736

IS - 4

ER -