Hidden mastocytosis in acute myeloid leukemia with t(8;21)(q22;q22)

Ryan C. Johnson, Natasha Marie Savage, Tsoyu Chiang, Jason R. Gotlib, Athena M. Cherry, Daniel A. Arber, Tracy I. George

Research output: Contribution to journalArticle

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Abstract

Objectives: To assess the frequency of systemic mastocytosis (SM) in a large series of acute myeloid leukemia (AML) with t(8;21)(q22;q22). Methods: We retrospectively characterized 40 bone marrow aspirate smears and biopsy specimens from patients with AML with t(8;21) for the presence of SM. Cases were assessed for mast cell morphology and immunohistochemistry, as well as KIT exon 8 and 17 mutational assessment by reverse transcription polymerase chain reaction. Results: Four patients met criteria for SM, 1 met criteria for myelomastocytic leukemia, and 8 demonstrated the benign finding of mast cell hyperplasia. Conclusions: We recommend examining all cases of AML with t(8;21) for the presence of SM via morphology, immunophenotyping, and KIT mutational analysis studies.

Original languageEnglish (US)
Pages (from-to)525-535
Number of pages11
JournalAmerican Journal of Clinical Pathology
Volume140
Issue number4
DOIs
StatePublished - Oct 1 2013

Fingerprint

Systemic Mastocytosis
Mastocytosis
Acute Myeloid Leukemia
Mast Cells
Immunophenotyping
Reverse Transcription
Hyperplasia
Exons
Leukemia
Bone Marrow
Immunohistochemistry
Biopsy
Polymerase Chain Reaction

Keywords

  • AML with t(8;21)
  • CD25
  • D816V
  • Exon 17 KIT mutations
  • Myelomastocytic leukemia
  • N822K
  • Systemic mastocytosis
  • Tryptase

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Johnson, R. C., Savage, N. M., Chiang, T., Gotlib, J. R., Cherry, A. M., Arber, D. A., & George, T. I. (2013). Hidden mastocytosis in acute myeloid leukemia with t(8;21)(q22;q22). American Journal of Clinical Pathology, 140(4), 525-535. https://doi.org/10.1309/AJCP1Q0YSXEAHNKK

Hidden mastocytosis in acute myeloid leukemia with t(8;21)(q22;q22). / Johnson, Ryan C.; Savage, Natasha Marie; Chiang, Tsoyu; Gotlib, Jason R.; Cherry, Athena M.; Arber, Daniel A.; George, Tracy I.

In: American Journal of Clinical Pathology, Vol. 140, No. 4, 01.10.2013, p. 525-535.

Research output: Contribution to journalArticle

Johnson, RC, Savage, NM, Chiang, T, Gotlib, JR, Cherry, AM, Arber, DA & George, TI 2013, 'Hidden mastocytosis in acute myeloid leukemia with t(8;21)(q22;q22)', American Journal of Clinical Pathology, vol. 140, no. 4, pp. 525-535. https://doi.org/10.1309/AJCP1Q0YSXEAHNKK
Johnson, Ryan C. ; Savage, Natasha Marie ; Chiang, Tsoyu ; Gotlib, Jason R. ; Cherry, Athena M. ; Arber, Daniel A. ; George, Tracy I. / Hidden mastocytosis in acute myeloid leukemia with t(8;21)(q22;q22). In: American Journal of Clinical Pathology. 2013 ; Vol. 140, No. 4. pp. 525-535.
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