Highly anti selective SN2′ additions of LiMe2Cu to chiral acyclic vinyloxiranes

James A. Marshall, Joseph D. Trometer, Bruce E. Blough, Thomas D. Crute

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Additions of LiMe2Cu to the trans and cis-Z vinyloxiranes 8 and 10 proceed with virtually 100% anti diastereoface selectivity to afford the syn-Z diol 12 and the anti-E diol 13 as the major products.

Original languageEnglish (US)
Pages (from-to)913-916
Number of pages4
JournalTetrahedron Letters
Issue number8
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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