Highly anti selective SN2′ additions of LiMe2Cu to chiral acyclic vinyloxiranes

James A. Marshall, Joseph D. Trometer, Bruce E. Blough, Thomas D Crute

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Additions of LiMe2Cu to the trans and cis-Z vinyloxiranes 8 and 10 proceed with virtually 100% anti diastereoface selectivity to afford the syn-Z diol 12 and the anti-E diol 13 as the major products.

Original languageEnglish (US)
Pages (from-to)913-916
Number of pages4
JournalTetrahedron Letters
Volume29
Issue number8
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Highly anti selective SN2′ additions of LiMe2Cu to chiral acyclic vinyloxiranes. / Marshall, James A.; Trometer, Joseph D.; Blough, Bruce E.; Crute, Thomas D.

In: Tetrahedron Letters, Vol. 29, No. 8, 01.01.1988, p. 913-916.

Research output: Contribution to journalArticle

Marshall, James A. ; Trometer, Joseph D. ; Blough, Bruce E. ; Crute, Thomas D. / Highly anti selective SN2′ additions of LiMe2Cu to chiral acyclic vinyloxiranes. In: Tetrahedron Letters. 1988 ; Vol. 29, No. 8. pp. 913-916.
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