High‐Resolution Proton Magnetic Resonance Analysis of Human Cerebrospinal Fluid

O. A.C. Petroff, R. K. Yu, T. Ogino

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

Abstract High‐resolution proton magnetic resonance spectroscopy was used to analyze human cerebrospinal fluid obtained from patients with several neurological problems. The major metabolites measured included glucose, lactate, glutamine, citrate, inositol, acetate, creatine, creatinine, β‐hydroxybutyrate, alanine, and pyruvate. A drug vehicle, propylene glycol, was also measured. Alterations in the cerebrospinal fluid of these metabolites provided information concerning metabolism of the brain. Magnetic resonance spectroscopy offered a simple and rapid means of assessing these and other exogenous and endogenous compounds in diseases affecting the nervous system.

Original languageEnglish (US)
Pages (from-to)1270-1276
Number of pages7
JournalJournal of Neurochemistry
Volume47
Issue number4
DOIs
StatePublished - Oct 1986
Externally publishedYes

Keywords

  • Cerebrospinal fluid
  • Human
  • Major metabolites
  • Nuclear magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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