High‐Resolution Proton Magnetic Resonance Analysis of Human Cerebrospinal Fluid

O. A C Petroff, Robert K Yu, T. Ogino

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Abstract High‐resolution proton magnetic resonance spectroscopy was used to analyze human cerebrospinal fluid obtained from patients with several neurological problems. The major metabolites measured included glucose, lactate, glutamine, citrate, inositol, acetate, creatine, creatinine, β‐hydroxybutyrate, alanine, and pyruvate. A drug vehicle, propylene glycol, was also measured. Alterations in the cerebrospinal fluid of these metabolites provided information concerning metabolism of the brain. Magnetic resonance spectroscopy offered a simple and rapid means of assessing these and other exogenous and endogenous compounds in diseases affecting the nervous system.

Original languageEnglish (US)
Pages (from-to)1270-1276
Number of pages7
JournalJournal of Neurochemistry
Volume47
Issue number4
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

Fingerprint

Magnetic resonance spectroscopy
Cerebrospinal fluid
Metabolites
Cerebrospinal Fluid
Protons
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Hydroxybutyrates
Propylene Glycol
Creatine
Neurology
Inositol
Nervous System Diseases
Glutamine
Pyruvic Acid
Metabolism
Citric Acid
Alanine
Lactic Acid
Brain

Keywords

  • Cerebrospinal fluid
  • Human
  • Major metabolites
  • Nuclear magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Cellular and Molecular Neuroscience

Cite this

High‐Resolution Proton Magnetic Resonance Analysis of Human Cerebrospinal Fluid. / Petroff, O. A C; Yu, Robert K; Ogino, T.

In: Journal of Neurochemistry, Vol. 47, No. 4, 01.01.1986, p. 1270-1276.

Research output: Contribution to journalArticle

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