Abstract
Abstract High‐resolution proton magnetic resonance spectroscopy was used to analyze human cerebrospinal fluid obtained from patients with several neurological problems. The major metabolites measured included glucose, lactate, glutamine, citrate, inositol, acetate, creatine, creatinine, β‐hydroxybutyrate, alanine, and pyruvate. A drug vehicle, propylene glycol, was also measured. Alterations in the cerebrospinal fluid of these metabolites provided information concerning metabolism of the brain. Magnetic resonance spectroscopy offered a simple and rapid means of assessing these and other exogenous and endogenous compounds in diseases affecting the nervous system.
Original language | English (US) |
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Pages (from-to) | 1270-1276 |
Number of pages | 7 |
Journal | Journal of Neurochemistry |
Volume | 47 |
Issue number | 4 |
DOIs | |
State | Published - Oct 1986 |
Externally published | Yes |
Keywords
- Cerebrospinal fluid
- Human
- Major metabolites
- Nuclear magnetic resonance spectroscopy
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience