HLA-G inhibits the functions of murine dendritic cells via the PIR-B immune inhibitory receptor

Siyuan Liang, Boris Baibakov, Anatolij Horuzsko

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114 Scopus citations

Abstract

Human histocompatibility leukocyte antigen (HLA)-G is an MHC class lb molecule that has been proposed to regulate immune responses during pregnancy. One of the possible mechanisms of that modulation is based on its interaction with immunoglobulin-like transcript (ILT) receptors. In this study, we show that HLA-G modifies the function of murine dendritic cells via interactions with the paired immunoglobulin-like inhibitory receptor, a homologue of the human inhibitory receptor ILT4. Triggering of the immune inhibitory receptors resulted in prolongation of allogeneic graft survival. This demonstration forms the basis for exploring and exploiting HLA-G molecules and immune inhibitory receptors in the development of a new therapeutic strategy to improve allogeneic graft survival.

Original languageEnglish (US)
Pages (from-to)2418-2426
Number of pages9
JournalEuropean Journal of Immunology
Volume32
Issue number9
DOIs
Publication statusPublished - Sep 1 2002

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Keywords

  • Dendritic cell
  • HLA-G
  • Hyporesponsiveness
  • Immune inhibitory receptor
  • Transgenic mouse

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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