Hormonal changes during long-term isolation

M. A. Custaud, Eric Jacques Belin de Chantemele, I. M. Larina, I. A. Nichiporuk, A. Grigoriev, M. Duvareille, Claude Gharib, G. Gauquelin-Koch

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Confinement and inactivity induce considerable psychological and physiological modifications through social and sensory deprivation. The aim of the SFINCSS-99 experiment was to determine the cardiovascular and hormonal pattern of blood volume regulation during long-term isolation and confinement. Simulation experiments were performed in pressurized chambers similar in size to the volumes of modern space vehicles. Group I consisted of four Russian male volunteers, who spent 240 days in a 100-m3 chamber. Group II included four males (one German and three Russians) who spent 110 days in isolation (200-m3 module). The blood samples, taken before, during and after the isolation period, were used to determine haematocrit (Ht), growth hormone (GH), active renin, aldosterone, and osmolality levels. From the urine samples, electrolytes, osmolality, nitrites, nitrates, cortisol, antidiuretic hormone (ADH), aldosterone, normetanephrine and metanephrine levels were determined. The increase in plasma volume (PV) that is associated with a tendency for a decrease in plasma active renin is likely to be due to decreased sympathetic activity, and concords with the changes in urinary catecholamine levels during confinement. Urinary catecholamine levels were significantly higher during the recovery period than during confinement. This suggests that the sympathoadrenal system was activated, and concords with the increase in heart rate. Vascular resistance is determined by not only the vasoconstrictor but also vasodilator systems. The ratio of nitrite/nitrate in urine, as an indicator of nitric oxide release, did not reveal any significant changes. Analysis of data suggests that the duration of the isolation was a main factor involved in the regulation of hormones.

Original languageEnglish (US)
Pages (from-to)508-515
Number of pages8
JournalEuropean Journal of Applied Physiology
Volume91
Issue number5-6
DOIs
StatePublished - May 1 2004

Fingerprint

Nitrites
Aldosterone
Renin
Nitrates
Osmolar Concentration
Catecholamines
Sensory Deprivation
Normetanephrine
Metanephrine
Urine
Plasma Volume
Vasoconstrictor Agents
Blood Volume
Vasopressins
Vasodilator Agents
Hematocrit
Vascular Resistance
Electrolytes
Growth Hormone
Hydrocortisone

Keywords

  • Confinement
  • Hormones
  • Isolation
  • Stress

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)

Cite this

Custaud, M. A., Belin de Chantemele, E. J., Larina, I. M., Nichiporuk, I. A., Grigoriev, A., Duvareille, M., ... Gauquelin-Koch, G. (2004). Hormonal changes during long-term isolation. European Journal of Applied Physiology, 91(5-6), 508-515. https://doi.org/10.1007/s00421-003-1027-8

Hormonal changes during long-term isolation. / Custaud, M. A.; Belin de Chantemele, Eric Jacques; Larina, I. M.; Nichiporuk, I. A.; Grigoriev, A.; Duvareille, M.; Gharib, Claude; Gauquelin-Koch, G.

In: European Journal of Applied Physiology, Vol. 91, No. 5-6, 01.05.2004, p. 508-515.

Research output: Contribution to journalArticle

Custaud, MA, Belin de Chantemele, EJ, Larina, IM, Nichiporuk, IA, Grigoriev, A, Duvareille, M, Gharib, C & Gauquelin-Koch, G 2004, 'Hormonal changes during long-term isolation', European Journal of Applied Physiology, vol. 91, no. 5-6, pp. 508-515. https://doi.org/10.1007/s00421-003-1027-8
Custaud MA, Belin de Chantemele EJ, Larina IM, Nichiporuk IA, Grigoriev A, Duvareille M et al. Hormonal changes during long-term isolation. European Journal of Applied Physiology. 2004 May 1;91(5-6):508-515. https://doi.org/10.1007/s00421-003-1027-8
Custaud, M. A. ; Belin de Chantemele, Eric Jacques ; Larina, I. M. ; Nichiporuk, I. A. ; Grigoriev, A. ; Duvareille, M. ; Gharib, Claude ; Gauquelin-Koch, G. / Hormonal changes during long-term isolation. In: European Journal of Applied Physiology. 2004 ; Vol. 91, No. 5-6. pp. 508-515.
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