Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas

Salama A. Salama, Shu Leong Ho, Hui Qun Wang, Jukka Tenhunen, Carola Tilgmann, Ayman Al-Hendy

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Catechol-O-methyl transferase (COMT) expression is higher in leiomyomas compared with paired normal myometrium. The expression of COMT in leiomyoma cells is hormonally regulated-estrogen down-regulates, whereas P and dexamethasone up-regulate, COMT expression.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalFertility and sterility
Volume86
Issue number1
DOIs
StatePublished - Jul 1 2006

Fingerprint

Guaiacol
Leiomyoma
Transferases
Myometrium
Dexamethasone
Estrogens
Up-Regulation
Down-Regulation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Salama, S. A., Ho, S. L., Wang, H. Q., Tenhunen, J., Tilgmann, C., & Al-Hendy, A. (2006). Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas. Fertility and sterility, 86(1), 259-262. https://doi.org/10.1016/j.fertnstert.2005.12.049

Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas. / Salama, Salama A.; Ho, Shu Leong; Wang, Hui Qun; Tenhunen, Jukka; Tilgmann, Carola; Al-Hendy, Ayman.

In: Fertility and sterility, Vol. 86, No. 1, 01.07.2006, p. 259-262.

Research output: Contribution to journalArticle

Salama, SA, Ho, SL, Wang, HQ, Tenhunen, J, Tilgmann, C & Al-Hendy, A 2006, 'Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas', Fertility and sterility, vol. 86, no. 1, pp. 259-262. https://doi.org/10.1016/j.fertnstert.2005.12.049
Salama, Salama A. ; Ho, Shu Leong ; Wang, Hui Qun ; Tenhunen, Jukka ; Tilgmann, Carola ; Al-Hendy, Ayman. / Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas. In: Fertility and sterility. 2006 ; Vol. 86, No. 1. pp. 259-262.
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