Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas

Salama A. Salama, Shu Leong Ho, Hui Qun Wang, Jukka Tenhunen, Carola Tilgmann, Ayman Al-Hendy

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Catechol-O-methyl transferase (COMT) expression is higher in leiomyomas compared with paired normal myometrium. The expression of COMT in leiomyoma cells is hormonally regulated-estrogen down-regulates, whereas P and dexamethasone up-regulate, COMT expression.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalFertility and sterility
Volume86
Issue number1
DOIs
StatePublished - Jul 1 2006

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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    Salama, S. A., Ho, S. L., Wang, H. Q., Tenhunen, J., Tilgmann, C., & Al-Hendy, A. (2006). Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas. Fertility and sterility, 86(1), 259-262. https://doi.org/10.1016/j.fertnstert.2005.12.049