HPV prevalence and its association with perinatal outcomes among singleton mothers

Analysis of pregnancy risk assessment and monitoring system (PRAMS) data, 2004-2011

Harpriya Kaur, Delf Schmidt-Grimminger, Baojiang Chen, Km Islam, Steven W. Remmenga, Robin High, Shinobu Watanabe-Galloway

Research output: Contribution to journalArticle

Abstract

Background: Pregnancy may increase the risk of Human Papillomavirus (HPV) infection because of pregnancy induced immune suppression. The objective of this study was to use a large population-based dataset to estimate the prevalence of HPV infection and its association with adverse outcomes among pregnant women. Methods: We analyzed Pregnancy Risk Monitoring System data from 2004-2011 (N=26,085) to estimate the self-reported HPV infection. Survey logistic procedures were used to examine the relationship between HPV infection and adverse perinatal outcomes. Results: Approximately 1.4% of women were estimated to have HPV infection during their pregnancy. The prevalence of adverse outcomes in this sample was preterm birth (8.4%), preeclampsia (7.5%), low birth weight (6.3%) and premature rupture of membranes (2.8%). Compared to women without HPV infection, HPV infection positive women were much more likely to have had other infections such as chlamydia (9.23% vs. 2.12%, p-value <.0001), Group B Strep (21.7% vs. 10.04%, p-value <.0001), and herpes (7.17% vs. 1.07%, p-value <.0001). After adjusting for other risk factors including other infections, HPV infection was significantly associated with low birth weight (OR: 1.94, 95% CI: 1.14-3.30). Conclusion: The study indicated a potential association between HPV infection and low birth weight. Because pregnant women with HPV infection are at higher risk of other infections, future research may focus on the roles of co-infection in the development of adverse perinatal effects.

Original languageEnglish (US)
Pages (from-to)143-149
Number of pages7
JournalCurrent Women's Health Reviews
Volume15
Issue number2
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Fingerprint

Papillomavirus Infections
Information Systems
Mothers
Pregnancy
Low Birth Weight Infant
Pregnant Women
Infection
Chlamydia
Premature Birth
Pre-Eclampsia
Coinfection
Rupture

Keywords

  • HPV
  • Low birth weight
  • PRAMS
  • PROM
  • Perinatal
  • Preeclampsia
  • Pregnancy
  • Preterm birth

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

HPV prevalence and its association with perinatal outcomes among singleton mothers : Analysis of pregnancy risk assessment and monitoring system (PRAMS) data, 2004-2011. / Kaur, Harpriya; Schmidt-Grimminger, Delf; Chen, Baojiang; Islam, Km; Remmenga, Steven W.; High, Robin; Watanabe-Galloway, Shinobu.

In: Current Women's Health Reviews, Vol. 15, No. 2, 01.01.2019, p. 143-149.

Research output: Contribution to journalArticle

Kaur, Harpriya ; Schmidt-Grimminger, Delf ; Chen, Baojiang ; Islam, Km ; Remmenga, Steven W. ; High, Robin ; Watanabe-Galloway, Shinobu. / HPV prevalence and its association with perinatal outcomes among singleton mothers : Analysis of pregnancy risk assessment and monitoring system (PRAMS) data, 2004-2011. In: Current Women's Health Reviews. 2019 ; Vol. 15, No. 2. pp. 143-149.
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abstract = "Background: Pregnancy may increase the risk of Human Papillomavirus (HPV) infection because of pregnancy induced immune suppression. The objective of this study was to use a large population-based dataset to estimate the prevalence of HPV infection and its association with adverse outcomes among pregnant women. Methods: We analyzed Pregnancy Risk Monitoring System data from 2004-2011 (N=26,085) to estimate the self-reported HPV infection. Survey logistic procedures were used to examine the relationship between HPV infection and adverse perinatal outcomes. Results: Approximately 1.4{\%} of women were estimated to have HPV infection during their pregnancy. The prevalence of adverse outcomes in this sample was preterm birth (8.4{\%}), preeclampsia (7.5{\%}), low birth weight (6.3{\%}) and premature rupture of membranes (2.8{\%}). Compared to women without HPV infection, HPV infection positive women were much more likely to have had other infections such as chlamydia (9.23{\%} vs. 2.12{\%}, p-value <.0001), Group B Strep (21.7{\%} vs. 10.04{\%}, p-value <.0001), and herpes (7.17{\%} vs. 1.07{\%}, p-value <.0001). After adjusting for other risk factors including other infections, HPV infection was significantly associated with low birth weight (OR: 1.94, 95{\%} CI: 1.14-3.30). Conclusion: The study indicated a potential association between HPV infection and low birth weight. Because pregnant women with HPV infection are at higher risk of other infections, future research may focus on the roles of co-infection in the development of adverse perinatal effects.",
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AB - Background: Pregnancy may increase the risk of Human Papillomavirus (HPV) infection because of pregnancy induced immune suppression. The objective of this study was to use a large population-based dataset to estimate the prevalence of HPV infection and its association with adverse outcomes among pregnant women. Methods: We analyzed Pregnancy Risk Monitoring System data from 2004-2011 (N=26,085) to estimate the self-reported HPV infection. Survey logistic procedures were used to examine the relationship between HPV infection and adverse perinatal outcomes. Results: Approximately 1.4% of women were estimated to have HPV infection during their pregnancy. The prevalence of adverse outcomes in this sample was preterm birth (8.4%), preeclampsia (7.5%), low birth weight (6.3%) and premature rupture of membranes (2.8%). Compared to women without HPV infection, HPV infection positive women were much more likely to have had other infections such as chlamydia (9.23% vs. 2.12%, p-value <.0001), Group B Strep (21.7% vs. 10.04%, p-value <.0001), and herpes (7.17% vs. 1.07%, p-value <.0001). After adjusting for other risk factors including other infections, HPV infection was significantly associated with low birth weight (OR: 1.94, 95% CI: 1.14-3.30). Conclusion: The study indicated a potential association between HPV infection and low birth weight. Because pregnant women with HPV infection are at higher risk of other infections, future research may focus on the roles of co-infection in the development of adverse perinatal effects.

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