Hydrolyzed formulas for allergy prevention

Yvan Vandenplas, Jatinder J Bhatia, Raanan Shamir, Carlo Agostoni, Dominique Turck, Annamaria Staiano, Hania Szajewska

Research output: Contribution to journalReview article

15 Scopus citations


Objectives: The aim of the present review was to provide recommendations on the use of hydrolysates in infants when formula feeding is initiated. Methods: We performed an overview of reviews followed by a systematic review of subsequently published trials. Results: We found 8 systematic reviews; only 1 study of limited quality was published afterwards. Certain extensively hydrolyzed casein and certain partially hydrolyzed whey formulas are appropriate for reducing the risk of allergy in infants at high risk when formula feeding is initiated. Conclusions: In high-risk infants, when breast-feeding is not possible, hydrolysates of documented safety and efficacy have an indication in infant feeding up to the age 4 to 6 months.

Original languageEnglish (US)
Pages (from-to)549-552
Number of pages4
JournalJournal of Pediatric Gastroenterology and Nutrition
Issue number5
StatePublished - May 2014



  • allergy
  • hydrolysate
  • infant nutrition
  • prevention

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

Cite this

Vandenplas, Y., Bhatia, J. J., Shamir, R., Agostoni, C., Turck, D., Staiano, A., & Szajewska, H. (2014). Hydrolyzed formulas for allergy prevention. Journal of Pediatric Gastroenterology and Nutrition, 58(5), 549-552. https://doi.org/10.1097/MPG.0000000000000318