Hypertension in black patients

An emerging role of the endothelin system in salt-sensitive hypertension

Adviye Ergul

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The prevalence of essential hypertension in blacks is much higher than that in whites. In addition, the pathogenesis of hypertension appears to be different in black patients. For example, black patients present with a salt- sensitive hypertension characterized by low renin levels. Racial differences in renal physiology and socioeconomic factors have been suggested as possible causes of this difference, but reasons for this difference remain unclear. Endothelial cells are important in the regulation of vascular tonus and homeostasis, in part through the secretion of vasoactive substances. One of these factors, endothelin-1 (ET-1), is a 21 amino acid residue peptide with potent vasopressor actions. In addition to its contractile effects, it has been shown to stimulate mitogenesis in a number of cell types. Moreover, ET-1 displays modulatory effects on the endocrine system, including stimulation of angiotensin II and aldosterone production and inhibition of antidiuretic hormone in the kidney. Recent data from several laboratories indicate that ET-1 is overexpressed in the vasculature in several salt-sensitive models of experimental hypertension. Moreover, circulating plasma ET-1 levels are significantly increased in black hypertensives compared with white hypertensives. Thus, the ET system might be particularly important in the development or maintenance of hypertension in this population.

Original languageEnglish (US)
Pages (from-to)62-67
Number of pages6
JournalHypertension
Volume36
Issue number1
DOIs
StatePublished - Jan 1 2000

Fingerprint

Endothelins
Endothelin-1
Salts
Hypertension
Kidney
Endocrine System
Aldosterone
Vasopressins
Renin
Angiotensin II
Blood Vessels
Homeostasis
Theoretical Models
Endothelial Cells
Cell Count
Maintenance
Amino Acids
Peptides
Population

Keywords

  • Blacks
  • Endothelin
  • Hypertension, essential
  • Race
  • Sodium, dietary

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Hypertension in black patients : An emerging role of the endothelin system in salt-sensitive hypertension. / Ergul, Adviye.

In: Hypertension, Vol. 36, No. 1, 01.01.2000, p. 62-67.

Research output: Contribution to journalArticle

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