Hypertension induced morphological and physiological changes in cells of the arterial wall

Patricia Martinez-Quinones; Cameron G. McCarthy; Stephanie W. Watts; Nicole S. Klee; Amel Komic; Fabiano B. Calmasini; Fernanda Priviero; Alexander Warner; Yu Chenghao; Camilla F. Wenceslau

doi:10.1093/ajh/hpy083

Hypertension induced morphological and physiological changes in cells of the arterial wall

Patricia Martinez-Quinones, Cameron G. McCarthy, Stephanie W. Watts, Nicole S. Klee, Amel Komic, Fabiano B. Calmasini, Fernanda Priviero, Alexander Warner, Yu Chenghao, Camilla F. Wenceslau

Physiology

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Morphological and physiological changes in the vasculature have been described in the evolution and maintenance of hypertension. Hypertension-induced vascular dysfunction may present itself as a contributing, or consequential factor, to vascular remodeling caused by chronically elevated systemic arterial blood pressure. Changes in all vessel layers, from the endothelium to the perivascular adipose tissue (PVAT), have been described. This mini-review focuses on the current knowledge of the structure and function of the vessel layers, specifically muscular arteries: intima, media, adventitia, PVAT, and the cell types harbored within each vessel layer. The contributions of each cell type to vessel homeostasis and pathophysiological development of hypertension will be highlighted.

Original language	English (US)
Pages (from-to)	1067-1078
Number of pages	12
Journal	American journal of hypertension
Volume	31
Issue number	10
DOIs	https://doi.org/10.1093/ajh/hpy083
State	Published - Sep 11 2018

Keywords

blood pressure; cell types
hypertension
vascular
vessel wall

ASJC Scopus subject areas

Internal Medicine

Access to Document

10.1093/ajh/hpy083

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Hypertension induced morphological and physiological changes in cells of the arterial wall. / Martinez-Quinones, Patricia; McCarthy, Cameron G.; Watts, Stephanie W.; Klee, Nicole S.; Komic, Amel; Calmasini, Fabiano B.; Priviero, Fernanda; Warner, Alexander; Chenghao, Yu; Wenceslau, Camilla F.

In: American journal of hypertension, Vol. 31, No. 10, 11.09.2018, p. 1067-1078.

Research output: Contribution to journal › Review article › peer-review

Martinez-Quinones, Patricia ; McCarthy, Cameron G. ; Watts, Stephanie W. ; Klee, Nicole S. ; Komic, Amel ; Calmasini, Fabiano B. ; Priviero, Fernanda ; Warner, Alexander ; Chenghao, Yu ; Wenceslau, Camilla F. / Hypertension induced morphological and physiological changes in cells of the arterial wall. In: American journal of hypertension. 2018 ; Vol. 31, No. 10. pp. 1067-1078.

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abstract = "Morphological and physiological changes in the vasculature have been described in the evolution and maintenance of hypertension. Hypertension-induced vascular dysfunction may present itself as a contributing, or consequential factor, to vascular remodeling caused by chronically elevated systemic arterial blood pressure. Changes in all vessel layers, from the endothelium to the perivascular adipose tissue (PVAT), have been described. This mini-review focuses on the current knowledge of the structure and function of the vessel layers, specifically muscular arteries: intima, media, adventitia, PVAT, and the cell types harbored within each vessel layer. The contributions of each cell type to vessel homeostasis and pathophysiological development of hypertension will be highlighted.",

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author = "Patricia Martinez-Quinones and McCarthy, {Cameron G.} and Watts, {Stephanie W.} and Klee, {Nicole S.} and Amel Komic and Calmasini, {Fabiano B.} and Fernanda Priviero and Alexander Warner and Yu Chenghao and Wenceslau, {Camilla F.}",

note = "Funding Information: We would like to acknowledge Drs O{\textquoteright}Connor and Crislip from the Department of Physiology at Augusta University, who kindly provided Figure 2 for this manuscript. We also would like to thank Lynsey Ekema, MSMI, for her artistic contribution to our Figure 3a,b. The work is funded by NIH through grant numbers P01 HL134604 and 1K99GM118885-01.",

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AU - Wenceslau, Camilla F.

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