TY - JOUR
T1 - Hypertension induced morphological and physiological changes in cells of the arterial wall
AU - Martinez-Quinones, Patricia
AU - McCarthy, Cameron G.
AU - Watts, Stephanie W.
AU - Klee, Nicole S.
AU - Komic, Amel
AU - Calmasini, Fabiano B.
AU - Priviero, Fernanda
AU - Warner, Alexander
AU - Chenghao, Yu
AU - Wenceslau, Camilla F.
N1 - Funding Information:
We would like to acknowledge Drs O’Connor and Crislip from the Department of Physiology at Augusta University, who kindly provided Figure 2 for this manuscript. We also would like to thank Lynsey Ekema, MSMI, for her artistic contribution to our Figure 3a,b. The work is funded by NIH through grant numbers P01 HL134604 and 1K99GM118885-01.
Publisher Copyright:
© American Journal of Hypertension, Ltd 2018. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
PY - 2018/9/11
Y1 - 2018/9/11
N2 - Morphological and physiological changes in the vasculature have been described in the evolution and maintenance of hypertension. Hypertension-induced vascular dysfunction may present itself as a contributing, or consequential factor, to vascular remodeling caused by chronically elevated systemic arterial blood pressure. Changes in all vessel layers, from the endothelium to the perivascular adipose tissue (PVAT), have been described. This mini-review focuses on the current knowledge of the structure and function of the vessel layers, specifically muscular arteries: intima, media, adventitia, PVAT, and the cell types harbored within each vessel layer. The contributions of each cell type to vessel homeostasis and pathophysiological development of hypertension will be highlighted.
AB - Morphological and physiological changes in the vasculature have been described in the evolution and maintenance of hypertension. Hypertension-induced vascular dysfunction may present itself as a contributing, or consequential factor, to vascular remodeling caused by chronically elevated systemic arterial blood pressure. Changes in all vessel layers, from the endothelium to the perivascular adipose tissue (PVAT), have been described. This mini-review focuses on the current knowledge of the structure and function of the vessel layers, specifically muscular arteries: intima, media, adventitia, PVAT, and the cell types harbored within each vessel layer. The contributions of each cell type to vessel homeostasis and pathophysiological development of hypertension will be highlighted.
KW - blood pressure; cell types
KW - hypertension
KW - vascular
KW - vessel wall
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U2 - 10.1093/ajh/hpy083
DO - 10.1093/ajh/hpy083
M3 - Review article
C2 - 29788246
AN - SCOPUS:85053816556
VL - 31
SP - 1067
EP - 1078
JO - American Journal of Hypertension
JF - American Journal of Hypertension
SN - 0895-7061
IS - 10
ER -