Hypothalamic-pituitary-ovarian axis disorders impacting female fertility

Sasha Mikhael, Advaita Punjala-Patel, Larisa Gavrilova-Jordan

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

The hypothalamic-pituitary-ovarian (HPO) axis is a tightly regulated system controlling female reproduction. HPO axis dysfunction leading to ovulation disorders can be classified into three categories defined by the World Health Organization (WHO). Group I ovulation disorders involve hypothalamic failure characterized as hypogonadotropic hypogonadism. Group II disorders display a eugonadal state commonly associated with a wide range of endocrinopathies. Finally, group III constitutes hypergonadotropic hypogonadism secondary to depleted ovarian function. Optimal evaluation and management of these disorders is based on a careful analysis tailored to each patient. This article reviews ovulation disorders based on pathophysiologic mechanisms, evaluation principles, and currently available management options.

Original languageEnglish (US)
Article number5
JournalBiomedicines
Volume7
Issue number1
DOIs
StatePublished - Mar 1 2019

Keywords

  • Hypothalamic-pituitary-ovarian axis
  • Infertility
  • Ovulatory dysfunction
  • Primary ovarian insufficiency
  • WHO ovulation disorders

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

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