Identification of CD15 as a Marker for Tumor-Propagating Cells in a Mouse Model of Medulloblastoma

Tracy Ann Read, Marie P. Fogarty, Shirley L. Markant, Roger E. McLendon, Zhengzheng Wei, David W. Ellison, Phillip G. Febbo, Robert J. Wechsler-Reya

Research output: Contribution to journalArticlepeer-review

273 Scopus citations

Abstract

The growth of many cancers depends on self-renewing cells called cancer stem cells or tumor-propagating cells (TPCs). In human brain tumors, cells expressing the stem cell marker CD133 have been implicated as TPCs. Here we show that tumors from a model of medulloblastoma, the Patched mutant mouse, are propagated not by CD133+ cells but by cells expressing the progenitor markers Math1 and CD15/SSEA-1. These cells have a distinct expression profile that suggests increased proliferative capacity and decreased tendency to undergo apoptosis and differentiation. CD15 is also found in a subset of human medulloblastomas, and tumors expressing genes similar to those found in murine CD15+ cells have a poorer prognosis. Thus, CD15 may represent an important marker for TPCs in medulloblastoma.

Original languageEnglish (US)
Pages (from-to)135-147
Number of pages13
JournalCancer Cell
Volume15
Issue number2
DOIs
StatePublished - Feb 3 2009
Externally publishedYes

Keywords

  • CELLCYCLE
  • STEMCELL

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Fingerprint Dive into the research topics of 'Identification of CD15 as a Marker for Tumor-Propagating Cells in a Mouse Model of Medulloblastoma'. Together they form a unique fingerprint.

Cite this