Abstract
Idiopathic hypogonadotropic hypogonadism (IHH) is a heterogeneous disorder displaying a range of phenotypic, genetic, and endocrinologic features. Current evidence suggests a deficiency in the hypothalamic release of pulsatile gonadatropin-releasing hormone (GnRH) in most patients. No genetic defects in the genes for GnRH, LHβ, or FSHβ have been described, although a deletion in the steroid sulfatase gene has been reported in X-linked Kallmann's syndrome with associated ichthyosis. Treatment with GnRH administered in a pulsatile fashion has been successful in inducing steroidogenesis and gametogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 111-118 |
| Number of pages | 8 |
| Journal | Adolescent and Pediatric Gynecology |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1991 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynecology
Cite this
Idiopathic hypogonadotropic hypogonadism : Diagnosis, pathogenesis, genetics, and treatment. / Layman, Lawrence C.
In: Adolescent and Pediatric Gynecology, Vol. 4, No. 3, 01.01.1991, p. 111-118.Research output: Contribution to journal › Short survey
}
TY - JOUR
T1 - Idiopathic hypogonadotropic hypogonadism
T2 - Diagnosis, pathogenesis, genetics, and treatment
AU - Layman, Lawrence C
PY - 1991/1/1
Y1 - 1991/1/1
N2 - Idiopathic hypogonadotropic hypogonadism (IHH) is a heterogeneous disorder displaying a range of phenotypic, genetic, and endocrinologic features. Current evidence suggests a deficiency in the hypothalamic release of pulsatile gonadatropin-releasing hormone (GnRH) in most patients. No genetic defects in the genes for GnRH, LHβ, or FSHβ have been described, although a deletion in the steroid sulfatase gene has been reported in X-linked Kallmann's syndrome with associated ichthyosis. Treatment with GnRH administered in a pulsatile fashion has been successful in inducing steroidogenesis and gametogenesis.
AB - Idiopathic hypogonadotropic hypogonadism (IHH) is a heterogeneous disorder displaying a range of phenotypic, genetic, and endocrinologic features. Current evidence suggests a deficiency in the hypothalamic release of pulsatile gonadatropin-releasing hormone (GnRH) in most patients. No genetic defects in the genes for GnRH, LHβ, or FSHβ have been described, although a deletion in the steroid sulfatase gene has been reported in X-linked Kallmann's syndrome with associated ichthyosis. Treatment with GnRH administered in a pulsatile fashion has been successful in inducing steroidogenesis and gametogenesis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026336979&partnerID=8YFLogxK
U2 - 10.1016/S0932-8610(19)80016-6
DO - 10.1016/S0932-8610(19)80016-6
M3 - Short survey
VL - 4
SP - 111
EP - 118
JO - Journal of Pediatric and Adolescent Gynecology
JF - Journal of Pediatric and Adolescent Gynecology
SN - 1083-3188
IS - 3
ER -