Idiopathic hypogonadotropic hypogonadism

Diagnosis, pathogenesis, genetics, and treatment

Research output: Contribution to journalShort survey

2 Citations (Scopus)

Abstract

Idiopathic hypogonadotropic hypogonadism (IHH) is a heterogeneous disorder displaying a range of phenotypic, genetic, and endocrinologic features. Current evidence suggests a deficiency in the hypothalamic release of pulsatile gonadatropin-releasing hormone (GnRH) in most patients. No genetic defects in the genes for GnRH, LHβ, or FSHβ have been described, although a deletion in the steroid sulfatase gene has been reported in X-linked Kallmann's syndrome with associated ichthyosis. Treatment with GnRH administered in a pulsatile fashion has been successful in inducing steroidogenesis and gametogenesis.

Original languageEnglish (US)
Pages (from-to)111-118
Number of pages8
JournalAdolescent and Pediatric Gynecology
Volume4
Issue number3
DOIs
StatePublished - Jan 1 1991

Fingerprint

Kallmann Syndrome
Steryl-Sulfatase
Hormones
Gametogenesis
Ichthyosis
Gonadotropin-Releasing Hormone
Genes
Therapeutics
Idiopathic Hypogonadotropic Hypogonadism

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Idiopathic hypogonadotropic hypogonadism : Diagnosis, pathogenesis, genetics, and treatment. / Layman, Lawrence C.

In: Adolescent and Pediatric Gynecology, Vol. 4, No. 3, 01.01.1991, p. 111-118.

Research output: Contribution to journalShort survey

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