IGF-1 induction by acylated steryl β-glucosides found in a pre-germinated brown rice diet reduces oxidative stress in streptozotocin-induced diabetes

Seigo Usuki, Ying Ying Tsai, Keiko Morikawa, Shota Nonaka, Yasuhide Okuhara, Mitsuo Kise, Robert K Yu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: The pathology of diabetic neuropathy involves oxidative stress on pancreatic β-cells, and is related to decreased levels of Insulin-like growth factor 1 (IGF-1). Acylated steryl β-glucoside (PR-ASG) found in pre-germiated brown rice is a bioactive substance exhibiting properties that enhance activity of homocysteine-thiolactonase (HTase), reducing oxidative stress in diabetic neuropathy. The biological importance of PR-ASG in pancreatic β-cells remains unknown. Here we examined the effects of PR-ASG on IGF-1 and glucose metabolism in β-cells exposed to oxidative stress. Methodology/Principal Findings: In the present study, a pre-germinated brown rice (PR)-diet was tested in streptozotocin (STZ)-induced diabetic rats. Compared with diabetic rats fed control diets, the PR-diet fed rats showed an improvement of serum metabolic and neurophysiological parameters. In addition, IGF-1 levels were found to be increased in the serum, liver, and pancreas of diabetic rats fed the PR-diet. The increased IGF-1 level in the pancreas led us to hypothesize that PR-ASG is protective for islet β-cells against the extensive injury of advanced or severe diabetes. Thus we examined PR-ASG to determine whether it showed anti-apoptotic, pro-proliferative effects on the insulin-secreting β-cells line, INS-1; and additionally, whether PR-ASG stimulated IGF-1 autocrine secretion/IGF-1-dependent glucose metabolism. We have demonstrated for the first time that PR-ASG increases IGF-1 production and secretion from pancreatic β-cells. Conclusion/Significance: These findings suggest that PR-ASG may affect pancreatic β-cells through the activation of an IGF-1-dependent mechanism in the diabetic condition. Thus, intake of pre-germinated brown rice may have a beneficial effect in the treatment of diabetes, in particular diabetic neuropathy.

Original languageEnglish (US)
Article numbere28693
JournalPLoS One
Volume6
Issue number12
DOIs
StatePublished - Dec 14 2011

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Oxidative stress
Experimental Diabetes Mellitus
brown rice
streptozotocin
Glucosides
somatomedins
Somatomedins
Nutrition
Streptozocin
Medical problems
glucosides
diabetes
Oxidative Stress
oxidative stress
Diet
diet
Rats
diabetic neuropathy
Diabetic Neuropathies
Metabolism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

IGF-1 induction by acylated steryl β-glucosides found in a pre-germinated brown rice diet reduces oxidative stress in streptozotocin-induced diabetes. / Usuki, Seigo; Tsai, Ying Ying; Morikawa, Keiko; Nonaka, Shota; Okuhara, Yasuhide; Kise, Mitsuo; Yu, Robert K.

In: PLoS One, Vol. 6, No. 12, e28693, 14.12.2011.

Research output: Contribution to journalArticle

Usuki, Seigo ; Tsai, Ying Ying ; Morikawa, Keiko ; Nonaka, Shota ; Okuhara, Yasuhide ; Kise, Mitsuo ; Yu, Robert K. / IGF-1 induction by acylated steryl β-glucosides found in a pre-germinated brown rice diet reduces oxidative stress in streptozotocin-induced diabetes. In: PLoS One. 2011 ; Vol. 6, No. 12.
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AU - Morikawa, Keiko

AU - Nonaka, Shota

AU - Okuhara, Yasuhide

AU - Kise, Mitsuo

AU - Yu, Robert K

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