IgM deficiency: Clinical spectrum and immunologic assessment

M. F. Guill, D. A. Brown, H. D. Ochs, K. H. Pyun, J. E. Moffitt

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Selective IgM deficiency has been associated with recurrent infections and enteric protein loss. We have evaluated eight patients with IgM deficiency presenting with recurrent infections and manifestations of atopy. A variety of subtle immunologic abeerrations were noted, including depressed IgM and elevated IgG responses to immunization with bacteriophage OX174. Despite normal quantitative IgG in most patients. IgG antibody responses to diphteria-tetanus and/or pneumococcal polysaccharide antigens were generally depressed. No correlation could be made between antibody responses (or lack thereof) and the nature of infections in any given patient.

Original languageEnglish (US)
Pages (from-to)547-552
Number of pages6
JournalAnnals of Allergy
Volume62
Issue number6
StatePublished - Jan 1 1989

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Immunoglobulin M
Immunoglobulin G
Antibody Formation
Infection
Tetanus
Bacteriophages
Polysaccharides
Immunization
Antigens
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Guill, M. F., Brown, D. A., Ochs, H. D., Pyun, K. H., & Moffitt, J. E. (1989). IgM deficiency: Clinical spectrum and immunologic assessment. Annals of Allergy, 62(6), 547-552.

IgM deficiency : Clinical spectrum and immunologic assessment. / Guill, M. F.; Brown, D. A.; Ochs, H. D.; Pyun, K. H.; Moffitt, J. E.

In: Annals of Allergy, Vol. 62, No. 6, 01.01.1989, p. 547-552.

Research output: Contribution to journalArticle

Guill, MF, Brown, DA, Ochs, HD, Pyun, KH & Moffitt, JE 1989, 'IgM deficiency: Clinical spectrum and immunologic assessment', Annals of Allergy, vol. 62, no. 6, pp. 547-552.
Guill MF, Brown DA, Ochs HD, Pyun KH, Moffitt JE. IgM deficiency: Clinical spectrum and immunologic assessment. Annals of Allergy. 1989 Jan 1;62(6):547-552.
Guill, M. F. ; Brown, D. A. ; Ochs, H. D. ; Pyun, K. H. ; Moffitt, J. E. / IgM deficiency : Clinical spectrum and immunologic assessment. In: Annals of Allergy. 1989 ; Vol. 62, No. 6. pp. 547-552.
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