Ileostomy creation in colorectal cancer surgery: risk of acute kidney injury and chronic kidney disease

Linda Li, Kelsey S. Lau, Venkat Ramanathan, Sonia T. Orcutt, Shubhada Sansgiry, Daniel Albo, David H. Berger, Daniel A. Anaya

Research output: Contribution to journalArticle

11 Scopus citations


Background Ileostomy creation is associated with postoperative dehydration and readmission; however, the effect on renal function is unknown. Our goal was to characterize the impact of ileostomy creation on acute and chronic renal function. Materials and methods A retrospective cohort study with patients undergoing colorectal cancer surgery at a tertiary referral institution (2005-2011). The relationship between ileostomy creation and acute kidney injury (AKI)-related readmission, severe chronic kidney disease (CKD) at 12 mo (glomerular filtration rate <30 mL/min/1.73 m2), and onset of severe CKD over time was evaluated using multivariable logistic and Cox regression and adjusted using propensity score stratification. Results Among 619 patients, 84 (13%) had ileostomy. AKI-related readmission and severe CKD at 12 mo were more common among ileostomy patients (17% versus 2%, P < 0.01 and 13.3% versus 5%, P = 0.02, respectively). After propensity score adjustment, ileostomy was a significant predictor of AKI-related readmissions (odds ratio: 10.3; 95% confidence interval [CI], 3.9-27.2), severe CKD at 12 mo (odds ratio: 4.1; 95% CI, 1.4-11.9), and onset of severe CKD over time (hazard ratio: 4.2; 95% CI, 2.3-6.6). Conclusions Ileostomy creation is associated with increased risk of AKI-related readmissions and development of severe CKD. Future studies must focus on strategies to minimize kidney injury when ileostomy is a necessary component of colorectal cancer surgery and revisiting current indications for ileostomy creation.

Original languageEnglish (US)
Pages (from-to)204-212
Number of pages9
JournalJournal of Surgical Research
StatePublished - Apr 1 2017



  • Acute kidney injury
  • Chronic renal insufficiency
  • Colorectal neoplasms
  • Ileostomy
  • Patient readmission

ASJC Scopus subject areas

  • Surgery

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