Abstract
Introduction In the setting of recurrent prostate cancer (PCa), awareness and understanding of clinical findings are essential for accurate imaging interpretation. Accordingly, this text will first address the principles of recurrent PCa management. Subsequently, the principles of recurrent PCa evaluation with computed tomography (CT), magnetic resonance imaging (MRI), transrectal ultrasound (TRUS), and TRUS-guided biopsy will be described. Nuclear medicine methods are reviewed in Chapter 11. Management principles of recurrent prostate cancer General principles Prostate cancer is usually suspected based on the detection of an abnormal serum prostate-specific antigen (PSA) value (≥4 ng/ml is the most commonly used criterion) and diagnosed by TRUS-guided systematic prostate biopsy [1]. With systematic biopsy, one or more cores are obtained from each prostate sextant regardless of TRUS findings [2]. Although optional additional cores can be obtained from regions that are abnormal on TRUS or other imaging modalities, image-guided biopsy is currently accepted only as an adjunct to systematic biopsy [2]. Biopsy results are used to assign the Gleason grade [3]. Digital rectal examination (DRE) findings are used to determine clinical tumor stage; however, due to earlier detection by PSA testing, PCa is now non-palpable in about two-thirds of patients and the clinical stage often underestimates the pathologic tumor stage [4, 5] (Table 12.1). Newly diagnosed PCa is designated as “primary” PCa and its treatment modalities are designated as “primary” treatments.
| Original language | English (US) |
|---|---|
| Title of host publication | Prostate Cancer |
| Publisher | Cambridge University Press |
| Pages | 195-222 |
| Number of pages | 28 |
| ISBN (Electronic) | 9780511551994 |
| ISBN (Print) | 9780521887045 |
| DOIs | |
| State | Published - Jan 1 2008 |
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ASJC Scopus subject areas
- Medicine(all)
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Imaging recurrent prostate cancer. / Sella, Tamar; Pucar, Darko.
Prostate Cancer. Cambridge University Press, 2008. p. 195-222.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Imaging recurrent prostate cancer
AU - Sella, Tamar
AU - Pucar, Darko
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Introduction In the setting of recurrent prostate cancer (PCa), awareness and understanding of clinical findings are essential for accurate imaging interpretation. Accordingly, this text will first address the principles of recurrent PCa management. Subsequently, the principles of recurrent PCa evaluation with computed tomography (CT), magnetic resonance imaging (MRI), transrectal ultrasound (TRUS), and TRUS-guided biopsy will be described. Nuclear medicine methods are reviewed in Chapter 11. Management principles of recurrent prostate cancer General principles Prostate cancer is usually suspected based on the detection of an abnormal serum prostate-specific antigen (PSA) value (≥4 ng/ml is the most commonly used criterion) and diagnosed by TRUS-guided systematic prostate biopsy [1]. With systematic biopsy, one or more cores are obtained from each prostate sextant regardless of TRUS findings [2]. Although optional additional cores can be obtained from regions that are abnormal on TRUS or other imaging modalities, image-guided biopsy is currently accepted only as an adjunct to systematic biopsy [2]. Biopsy results are used to assign the Gleason grade [3]. Digital rectal examination (DRE) findings are used to determine clinical tumor stage; however, due to earlier detection by PSA testing, PCa is now non-palpable in about two-thirds of patients and the clinical stage often underestimates the pathologic tumor stage [4, 5] (Table 12.1). Newly diagnosed PCa is designated as “primary” PCa and its treatment modalities are designated as “primary” treatments.
AB - Introduction In the setting of recurrent prostate cancer (PCa), awareness and understanding of clinical findings are essential for accurate imaging interpretation. Accordingly, this text will first address the principles of recurrent PCa management. Subsequently, the principles of recurrent PCa evaluation with computed tomography (CT), magnetic resonance imaging (MRI), transrectal ultrasound (TRUS), and TRUS-guided biopsy will be described. Nuclear medicine methods are reviewed in Chapter 11. Management principles of recurrent prostate cancer General principles Prostate cancer is usually suspected based on the detection of an abnormal serum prostate-specific antigen (PSA) value (≥4 ng/ml is the most commonly used criterion) and diagnosed by TRUS-guided systematic prostate biopsy [1]. With systematic biopsy, one or more cores are obtained from each prostate sextant regardless of TRUS findings [2]. Although optional additional cores can be obtained from regions that are abnormal on TRUS or other imaging modalities, image-guided biopsy is currently accepted only as an adjunct to systematic biopsy [2]. Biopsy results are used to assign the Gleason grade [3]. Digital rectal examination (DRE) findings are used to determine clinical tumor stage; however, due to earlier detection by PSA testing, PCa is now non-palpable in about two-thirds of patients and the clinical stage often underestimates the pathologic tumor stage [4, 5] (Table 12.1). Newly diagnosed PCa is designated as “primary” PCa and its treatment modalities are designated as “primary” treatments.
UR - http://www.scopus.com/inward/record.url?scp=77953428557&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953428557&partnerID=8YFLogxK
U2 - 10.1017/CBO9780511551994.014
DO - 10.1017/CBO9780511551994.014
M3 - Chapter
AN - SCOPUS:77953428557
SN - 9780521887045
SP - 195
EP - 222
BT - Prostate Cancer
PB - Cambridge University Press
ER -