Immune abnormalities in IgA nephropathy (Berger's disease)

Irene Stachura, Gurmukh Singh, Theresa L. Whiteside

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Thirteen patients with IgA nephropathy confirmed by renal biopsies were studied for evidence of disorders of the immune system. Circulating immune complexes (CIC) were determined by agarose gel zone electrophoresis (AGE), the Raji cell radioimmunoassay (RIA), and the modified Raji cell (RIA) for IgA containing CIC. Serum levels of immunoglobulins (Ig) G, A, M, of C3, C4, and properdin factor B (PFB) were measured by the rate nephelometry. Tissue studies included fluorescent, light, and electron microscopy, staining for intracellular Ig, and lysozyme by immunoperoxidase (IP), and determination of glomerular C3 receptors (C3R) by EAC rosettes. IgG-CIC were detected in 69%, IgA-CIC in 50% and serum IgA was elevated (>2SD) in 46% of the patients. In the glomeruli, mesangial deposits of IgA, IgG, properdin, and C3 were present. C3R available for EAC binding to glomerular cells were decreased. IgA-producing lymphoid cells were detected in renal interstitium of our patients especially those with crescentic glomerulonephritis. Elevated serum IgA and the presence of IgA-producing cells in the renal tissue may reflect an abnormality in IgA immunoregulatory mechanisms. IgA could contribute to the pathogenesis of renal disease due to its inhibitory effect on the clearance of circulating and deposited immune complexes.

Original languageEnglish (US)
Pages (from-to)373-388
Number of pages16
JournalClinical Immunology and Immunopathology
Volume20
Issue number3
DOIs
StatePublished - Jan 1 1981
Externally publishedYes

Fingerprint

IGA Glomerulonephritis
Immunoglobulin A
Antigen-Antibody Complex
Kidney
Immunoglobulin G
Radioimmunoassay
Serum
Properdin
Nephelometry and Turbidimetry
Complement Factor B
Agar Gel Electrophoresis
Muramidase
Glomerulonephritis
Immunoglobulins
Immune System
Electron Microscopy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

Cite this

Immune abnormalities in IgA nephropathy (Berger's disease). / Stachura, Irene; Singh, Gurmukh; Whiteside, Theresa L.

In: Clinical Immunology and Immunopathology, Vol. 20, No. 3, 01.01.1981, p. 373-388.

Research output: Contribution to journalArticle

Stachura, Irene ; Singh, Gurmukh ; Whiteside, Theresa L. / Immune abnormalities in IgA nephropathy (Berger's disease). In: Clinical Immunology and Immunopathology. 1981 ; Vol. 20, No. 3. pp. 373-388.
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