Immunoreactive interleukin-1β localization in the rat forebrain

Ronald M. Lechan, R. Toni, B. D. Clark, J. G. Cannon, A. R. Shaw, C. A. Dinarello, S. Reichlin

Research output: Contribution to journalArticle

319 Scopus citations

Abstract

To determine whether the cytokine, interleukin-1β, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1β. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1β is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.

Original languageEnglish (US)
Pages (from-to)135-140
Number of pages6
JournalBrain Research
Volume514
Issue number1
DOIs
StatePublished - Apr 23 1990

Keywords

  • Cytokine
  • Hippocampus
  • Hypothalamus
  • Immunocytochemistry
  • Interleukin-1
  • Olfactory tubercle

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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  • Cite this

    Lechan, R. M., Toni, R., Clark, B. D., Cannon, J. G., Shaw, A. R., Dinarello, C. A., & Reichlin, S. (1990). Immunoreactive interleukin-1β localization in the rat forebrain. Brain Research, 514(1), 135-140. https://doi.org/10.1016/0006-8993(90)90445-H