Immunoreactive interleukin-1β localization in the rat forebrain

Ronald M. Lechan, R. Toni, B. D. Clark, Joseph Gerard Cannon, A. R. Shaw, C. A. Dinarello, S. Reichlin

Research output: Contribution to journalArticle

316 Citations (Scopus)

Abstract

To determine whether the cytokine, interleukin-1β, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1β. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1β is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.

Original languageEnglish (US)
Pages (from-to)135-140
Number of pages6
JournalBrain Research
Volume514
Issue number1
DOIs
StatePublished - Apr 23 1990

Fingerprint

Prosencephalon
Interleukin-1
Middle Hypothalamus
Brain
Immune Sera
Hippocampus
Central Nervous System
Cytokines

Keywords

  • Cytokine
  • Hippocampus
  • Hypothalamus
  • Immunocytochemistry
  • Interleukin-1
  • Olfactory tubercle

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Lechan, R. M., Toni, R., Clark, B. D., Cannon, J. G., Shaw, A. R., Dinarello, C. A., & Reichlin, S. (1990). Immunoreactive interleukin-1β localization in the rat forebrain. Brain Research, 514(1), 135-140. https://doi.org/10.1016/0006-8993(90)90445-H

Immunoreactive interleukin-1β localization in the rat forebrain. / Lechan, Ronald M.; Toni, R.; Clark, B. D.; Cannon, Joseph Gerard; Shaw, A. R.; Dinarello, C. A.; Reichlin, S.

In: Brain Research, Vol. 514, No. 1, 23.04.1990, p. 135-140.

Research output: Contribution to journalArticle

Lechan, RM, Toni, R, Clark, BD, Cannon, JG, Shaw, AR, Dinarello, CA & Reichlin, S 1990, 'Immunoreactive interleukin-1β localization in the rat forebrain', Brain Research, vol. 514, no. 1, pp. 135-140. https://doi.org/10.1016/0006-8993(90)90445-H
Lechan RM, Toni R, Clark BD, Cannon JG, Shaw AR, Dinarello CA et al. Immunoreactive interleukin-1β localization in the rat forebrain. Brain Research. 1990 Apr 23;514(1):135-140. https://doi.org/10.1016/0006-8993(90)90445-H
Lechan, Ronald M. ; Toni, R. ; Clark, B. D. ; Cannon, Joseph Gerard ; Shaw, A. R. ; Dinarello, C. A. ; Reichlin, S. / Immunoreactive interleukin-1β localization in the rat forebrain. In: Brain Research. 1990 ; Vol. 514, No. 1. pp. 135-140.
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