Impact of muscle atrophy on bone metabolism and bone strength: implications for muscle-bone crosstalk with aging and disuse

T. Bettis, B. J. Kim, M. W. Hamrick

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Bone fractures in older adults are often preceded by a loss of muscle mass and strength. Likewise, bone loss with prolonged bed rest, spinal cord injury, or with exposure to microgravity is also preceded by a rapid loss of muscle mass. Recent studies using animal models in the setting of hindlimb unloading or botulinum toxin (Botox) injection also reveal that muscle loss can induce bone loss. Moreover, muscle-derived factors such as irisin and leptin can inhibit bone loss with unloading, and knockout of catabolic factors in muscle such as the ubiquitin ligase Murf1 or the myokine myostatin can reduce osteoclastogenesis. These findings suggest that therapies targeting muscle in the setting of disuse atrophy may potentially attenuate bone loss, primarily by reducing bone resorption. These potential therapies not only include pharmacological approaches but also interventions such as whole-body vibration coupled with resistance exercise and functional electric stimulation of muscle.

Original languageEnglish (US)
Pages (from-to)1713-1720
Number of pages8
JournalOsteoporosis International
Volume29
Issue number8
DOIs
StatePublished - Aug 1 2018

Fingerprint

Muscular Atrophy
Muscle Strength
Bone and Bones
Muscles
Atrophic Muscular Disorders
Myostatin
Hindlimb Suspension
Weightlessness
Bed Rest
Botulinum Toxins
Bone Fractures
Ligases
Bone Resorption
Ubiquitin
Leptin
Vibration
Spinal Cord Injuries
Osteogenesis
Electric Stimulation
Animal Models

Keywords

  • Irisin
  • Microgravity
  • Myostatin
  • Osteoclasts
  • Resistance training

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Impact of muscle atrophy on bone metabolism and bone strength : implications for muscle-bone crosstalk with aging and disuse. / Bettis, T.; Kim, B. J.; Hamrick, M. W.

In: Osteoporosis International, Vol. 29, No. 8, 01.08.2018, p. 1713-1720.

Research output: Contribution to journalReview article

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