Impact of obesity and insulin resistance on vasomotor tone: Nitric oxide and beyond

Research output: Contribution to journalShort survey

35 Citations (Scopus)

Abstract

1. Obesity is rapidly increasing in Western populations, driving a parallel increase in hypertension, diabetes and vascular disease. Prior to the development of overt diabetes or hypertension, obese patients spend years in a state of progressive insulin resistance and metabolic disease. Mounting evidence suggests that this insulin-resistant state has deleterious effects on the control of blood flow, thus placing organ systems at a higher risk for end-organ damage and increasing cardiovascular mortality. 2. The purpose of the present review is to examine the current literature on the effects of obesity and insulin resistance on the acute control of vascular tone. Effects on nitric oxide (NO)-mediated control of vascular tone are particularly examined with regard to proximal causes and distal mechanisms of the impaired NO-mediation of vasodilation. 3. Finally, novel pathways of impaired control of perfusion are summarized from the recent literature to identify new avenues of exploring impaired vascular function in patients with metabolic disease.

Original languageEnglish (US)
Pages (from-to)407-414
Number of pages8
JournalClinical and Experimental Pharmacology and Physiology
Volume33
Issue number5-6
DOIs
StatePublished - May 1 2006

Fingerprint

Blood Vessels
Insulin Resistance
Nitric Oxide
Obesity
Metabolic Diseases
Hypertension
Vascular Diseases
Vasodilation
Perfusion
Insulin
Mortality
Population

Keywords

  • Adrenergic
  • Angiotensin II
  • Endothelin
  • Endothelium
  • Insulin resistance
  • Sympathetic

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

Impact of obesity and insulin resistance on vasomotor tone : Nitric oxide and beyond. / Stepp, David W.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 33, No. 5-6, 01.05.2006, p. 407-414.

Research output: Contribution to journalShort survey

@article{58f5135c92e94509b56ff9f38beb7ec9,
title = "Impact of obesity and insulin resistance on vasomotor tone: Nitric oxide and beyond",
abstract = "1. Obesity is rapidly increasing in Western populations, driving a parallel increase in hypertension, diabetes and vascular disease. Prior to the development of overt diabetes or hypertension, obese patients spend years in a state of progressive insulin resistance and metabolic disease. Mounting evidence suggests that this insulin-resistant state has deleterious effects on the control of blood flow, thus placing organ systems at a higher risk for end-organ damage and increasing cardiovascular mortality. 2. The purpose of the present review is to examine the current literature on the effects of obesity and insulin resistance on the acute control of vascular tone. Effects on nitric oxide (NO)-mediated control of vascular tone are particularly examined with regard to proximal causes and distal mechanisms of the impaired NO-mediation of vasodilation. 3. Finally, novel pathways of impaired control of perfusion are summarized from the recent literature to identify new avenues of exploring impaired vascular function in patients with metabolic disease.",
keywords = "Adrenergic, Angiotensin II, Endothelin, Endothelium, Insulin resistance, Sympathetic",
author = "Stepp, {David W.}",
year = "2006",
month = "5",
day = "1",
doi = "10.1111/j.1440-1681.2006.04381.x",
language = "English (US)",
volume = "33",
pages = "407--414",
journal = "Clinical and Experimental Pharmacology and Physiology",
issn = "0305-1870",
publisher = "Wiley-Blackwell",
number = "5-6",

}

TY - JOUR

T1 - Impact of obesity and insulin resistance on vasomotor tone

T2 - Nitric oxide and beyond

AU - Stepp, David W.

PY - 2006/5/1

Y1 - 2006/5/1

N2 - 1. Obesity is rapidly increasing in Western populations, driving a parallel increase in hypertension, diabetes and vascular disease. Prior to the development of overt diabetes or hypertension, obese patients spend years in a state of progressive insulin resistance and metabolic disease. Mounting evidence suggests that this insulin-resistant state has deleterious effects on the control of blood flow, thus placing organ systems at a higher risk for end-organ damage and increasing cardiovascular mortality. 2. The purpose of the present review is to examine the current literature on the effects of obesity and insulin resistance on the acute control of vascular tone. Effects on nitric oxide (NO)-mediated control of vascular tone are particularly examined with regard to proximal causes and distal mechanisms of the impaired NO-mediation of vasodilation. 3. Finally, novel pathways of impaired control of perfusion are summarized from the recent literature to identify new avenues of exploring impaired vascular function in patients with metabolic disease.

AB - 1. Obesity is rapidly increasing in Western populations, driving a parallel increase in hypertension, diabetes and vascular disease. Prior to the development of overt diabetes or hypertension, obese patients spend years in a state of progressive insulin resistance and metabolic disease. Mounting evidence suggests that this insulin-resistant state has deleterious effects on the control of blood flow, thus placing organ systems at a higher risk for end-organ damage and increasing cardiovascular mortality. 2. The purpose of the present review is to examine the current literature on the effects of obesity and insulin resistance on the acute control of vascular tone. Effects on nitric oxide (NO)-mediated control of vascular tone are particularly examined with regard to proximal causes and distal mechanisms of the impaired NO-mediation of vasodilation. 3. Finally, novel pathways of impaired control of perfusion are summarized from the recent literature to identify new avenues of exploring impaired vascular function in patients with metabolic disease.

KW - Adrenergic

KW - Angiotensin II

KW - Endothelin

KW - Endothelium

KW - Insulin resistance

KW - Sympathetic

UR - http://www.scopus.com/inward/record.url?scp=33745223072&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745223072&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1681.2006.04381.x

DO - 10.1111/j.1440-1681.2006.04381.x

M3 - Short survey

C2 - 16700872

AN - SCOPUS:33745223072

VL - 33

SP - 407

EP - 414

JO - Clinical and Experimental Pharmacology and Physiology

JF - Clinical and Experimental Pharmacology and Physiology

SN - 0305-1870

IS - 5-6

ER -