Impact of tricyclic antidepressants, selective serotonin reuptake inhibitors, and other antidepressants on overall survival of patients with advanced lung cancer from 2004 to 2014: University of Cincinnati experience

Nagla Fawzy Abdel Karim, Rammey Hassan, Nabeela Iffat Siddiqi, Ihab Eldessouki, Ola Gaber, Mohamed Rahouma, Mohamed Kamel, Mhender Yellu, Shuchi Gulati, Changchun Xie, Mohamed Magdy, Jane Pruemer

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Objectives: To evaluate and categorize the survival benefit of tricyclic antidepressants (TCAs) in lung cancer patients based on systematic computational drug repositioning data. Methods: Data were retrospectively extracted from the medical records of non-small cell lung cancer (NSCLC) patients from the University of Cincinnati Cancer Medical Center database. Patients receiving antidepressants during their course of anti-cancer treatment were compared with those without antidepressants. Data were analyzed using Kaplan–Meier survival curves with the log-rank test, and overall survival (OS) was calculated from the date of diagnosis until last follow-up or death. Results: The median OS at 2 and 5 years for patients on antidepressants was 20.3 months (54.7% and 42%) vs 44.3 months (47.6% and 43.2%), which was not significant. The median OS for patients receiving TCAs, selective serotonin reuptake inhibitors, and other antidepressants was 3.17 months, 31.33 months, and 18.50 months, respectively. Conclusion: We found no significant survival benefit for TCA use in combination with anti-cancer agents in NSCLC patients.

Original languageEnglish (US)
Pages (from-to)6016-6026
Number of pages11
JournalJournal of International Medical Research
Volume47
Issue number12
DOIs
StatePublished - Dec 1 2019
Externally publishedYes

Keywords

  • Lung cancer
  • SSRIs
  • apoptosis
  • drug repositioning
  • overall survival
  • tricyclic antidepressants

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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