Implementation of hypoxia measurement into lung cancer therapy

Xue Meng, Feng Ming Spring Kong, Jinming Yu

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Tumor hypoxia has been found to be a characteristic feature in lung cancer. It has been shown to decrease the therapeutic efficacy of radiotherapy and some forms of chemotherapy. New methods for qualitative and quantitative assessment of tumor oxygenation have made it possible to establish the prognostic significance of tumor hypoxia. The ability to determine the degree and extent of hypoxia in lung cancer is not only important prognostically, but also in the selection of patients for hypoxia-modifying treatments. To provide the best attainable quality of life for individual patients it is of increasing importance that tools be developed that allow a better selection of patients for these intensified treatment strategies. Although some markers and combinations have shown potential benefit and are associated with treatment outcome, their clinical usefulness needs to be validated in prospective trials. A review of published studies was carried out, focusing on the assessment of tumor hypoxia and the possibilities to overcome hypoxia during treatment in lung cancer.

Original languageEnglish (US)
Pages (from-to)146-150
Number of pages5
JournalLung Cancer
Volume75
Issue number2
DOIs
StatePublished - Feb 1 2012

Fingerprint

Lung Neoplasms
Patient Selection
Therapeutics
Radiotherapy
Quality of Life
Drug Therapy
Hypoxia
Tumor Hypoxia
Neoplasms

Keywords

  • FAZA
  • FETNIM
  • FMISO
  • Hypoxia
  • Lung cancer
  • PET imaging

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Implementation of hypoxia measurement into lung cancer therapy. / Meng, Xue; Kong, Feng Ming Spring; Yu, Jinming.

In: Lung Cancer, Vol. 75, No. 2, 01.02.2012, p. 146-150.

Research output: Contribution to journalReview article

Meng, Xue ; Kong, Feng Ming Spring ; Yu, Jinming. / Implementation of hypoxia measurement into lung cancer therapy. In: Lung Cancer. 2012 ; Vol. 75, No. 2. pp. 146-150.
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