Implications for tumor microenvironment and epithelial crosstalk in the management of gastrointestinal cancers

Yang Ge, C. Benedikt Westphalen, Wen Wee Ma, Kenneth J. Vega, Nathaniel Weygant

Research output: Contribution to journalReview article

Abstract

Rapid advances in technology are revealing previously unknown organization, cooperation, and limitations within the population of nontumor cells surrounding the tumor epithelium known as the tumor microenvironment (TME). Nowhere are these findings more pertinent than in the gastrointestinal (GI) tract where exquisite cell specialization supports a complex microenvironmental niche characterized by rapid stemness-associated cell turnover, pathogen sensing, epithelial orchestration of immune signaling, and other facets that maintain the complex balance between homeostasis, inflammation, and disease. Here, we summarize and discuss select emerging concepts in the precancerous microenvironment, TME, and tumor epithelial-TME crosstalk as well as their implications for the management of GI cancers.

Original languageEnglish (US)
Article number4835318
JournalJournal of Oncology
Volume2019
DOIs
StatePublished - Jan 1 2019

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ASJC Scopus subject areas

  • Oncology

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