Abstract
Impoverished rearing conditions deregulate metabotropic glutamate receptor (mGluR) function and expression within the prefrontal cortex, which contributes to poor performance in positively reinforced spatial working memory tasks. This study extended earlier data by demonstrating that impoverished rearing conditions impair spatial working memory even under conditions of negative reinforcement, indicating a generalized deficit in working memory processing. This protracted behavioral effect was associated with reduced total prefrontal cortex levels of the active, dimerized form of mGluR 5, but there was no change in mGluR 1 or mGluR 2/3 dimer expression in any brain region examined. Thus, impoverished rearing conditions produce protracted deficits in spatial working memory, in association with reduced prefrontal mGluR 5 function that may be relevant to the etiology of several neuropsychiatric disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 239-243 |
| Number of pages | 5 |
| Journal | NeuroReport |
| Volume | 19 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2008 |
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Keywords
- Impoverished environment
- Metabotropic glutamate receptors
- Negative reinforcement
- Prefrontal cortex
- Spatial working memory
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Impoverished rearing impairs working memory and metabotropic glutamate receptor 5 expression. / Gregory, Mary L; Szumlinski, Karen K.
In: NeuroReport, Vol. 19, No. 2, 01.01.2008, p. 239-243.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impoverished rearing impairs working memory and metabotropic glutamate receptor 5 expression
AU - Gregory, Mary L
AU - Szumlinski, Karen K.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Impoverished rearing conditions deregulate metabotropic glutamate receptor (mGluR) function and expression within the prefrontal cortex, which contributes to poor performance in positively reinforced spatial working memory tasks. This study extended earlier data by demonstrating that impoverished rearing conditions impair spatial working memory even under conditions of negative reinforcement, indicating a generalized deficit in working memory processing. This protracted behavioral effect was associated with reduced total prefrontal cortex levels of the active, dimerized form of mGluR 5, but there was no change in mGluR 1 or mGluR 2/3 dimer expression in any brain region examined. Thus, impoverished rearing conditions produce protracted deficits in spatial working memory, in association with reduced prefrontal mGluR 5 function that may be relevant to the etiology of several neuropsychiatric disorders.
AB - Impoverished rearing conditions deregulate metabotropic glutamate receptor (mGluR) function and expression within the prefrontal cortex, which contributes to poor performance in positively reinforced spatial working memory tasks. This study extended earlier data by demonstrating that impoverished rearing conditions impair spatial working memory even under conditions of negative reinforcement, indicating a generalized deficit in working memory processing. This protracted behavioral effect was associated with reduced total prefrontal cortex levels of the active, dimerized form of mGluR 5, but there was no change in mGluR 1 or mGluR 2/3 dimer expression in any brain region examined. Thus, impoverished rearing conditions produce protracted deficits in spatial working memory, in association with reduced prefrontal mGluR 5 function that may be relevant to the etiology of several neuropsychiatric disorders.
KW - Impoverished environment
KW - Metabotropic glutamate receptors
KW - Negative reinforcement
KW - Prefrontal cortex
KW - Spatial working memory
UR - http://www.scopus.com/inward/record.url?scp=38049139188&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38049139188&partnerID=8YFLogxK
U2 - 10.1097/WNR.0b013e3282f4aa15
DO - 10.1097/WNR.0b013e3282f4aa15
M3 - Article
C2 - 18185116
AN - SCOPUS:38049139188
VL - 19
SP - 239
EP - 243
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 2
ER -