Improving neuron-to-electrode Surface attachment via alkanethiol self-assembly: An alternating current impedance study

Gymama E. Slaughter, Erhard Bieberich, Gary E. Wnek, Kenneth J. Wynne, Anthony Guiseppi-Elie

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The phenomena of neuron-to-electrode surface attachment NESA) via self-assembly of alkanethiol was investigated. The phenomena of hysteresis indicated cysteamine (CA) self-assembly monolayers (SAM) displays greater amphiphilic character than 11-amino-1-undecanethiol (11-AUT)-SAM. The tapping mode atomic force microscopy (AFM) also confirmed 6% increase and 22% decrease in surface roughness when compared to clean, unmodified and sputter-deposited gold. The results show that covalent immobilization of adhesion-promoting proteins enhanced NESA by tightly anchoring cells to electrode.

Original languageEnglish (US)
Pages (from-to)7189-7200
Number of pages12
JournalLangmuir
Volume20
Issue number17
DOIs
StatePublished - Aug 17 2004

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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    Slaughter, G. E., Bieberich, E., Wnek, G. E., Wynne, K. J., & Guiseppi-Elie, A. (2004). Improving neuron-to-electrode Surface attachment via alkanethiol self-assembly: An alternating current impedance study. Langmuir, 20(17), 7189-7200. https://doi.org/10.1021/la049192s