In vitro remineralization of severely compromised bonded dentin

S. Mai, Y. K. Kim, J. Kim, C. K.Y. Yiu, J. Ling, David Henry Pashley, Franklin Chi Meng Tay

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Biomimetic remineralization is potentially useful for the remineralization of incompletely resin-infiltrated collagen matrices created by etch-and-rinse adhesives. In this study, we tested the hypothesis that structurally altered dentin collagen cannot be remineralized to the same hierarchical order and dimension seen in structurally intact dentin collagen. The remineralization medium consisted of a set Portland cement/simulated body fluid system containing polycarboxylic acid and polyvinylphosphonic acid as biomimetic analogs. Remineralization of air-dried, collapsed hybrid layers was apparent after one month, with hybrid layers remineralized to 80-90% of their thickness after 2-4 months. A hypermineralized layer was seen on the hybrid layer surface, and tubular orifices were occluded with apatite deposits that resembled those present in non-carious cervical dentin. Structurally altered collagen is unlikely to be remineralized to the same hierarchical order and dimension as seen in intact dentin. The aggressively air-dried acid-etched dentin remineralization model also sheds light on the mechanism of sclerotic dentin formation.

Original languageEnglish (US)
Pages (from-to)405-410
Number of pages6
JournalJournal of Dental Research
Volume89
Issue number4
DOIs
StatePublished - Apr 1 2010

Fingerprint

Dentin
Collagen
Biomimetics
Acids
Air
Apatites
Body Fluids
Adhesives
In Vitro Techniques

Keywords

  • Biomimetic analogs
  • Hypermineralized dentin.
  • Intrafibrillar remineralization
  • Remineralization
  • Structurally altered collagen

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Mai, S., Kim, Y. K., Kim, J., Yiu, C. K. Y., Ling, J., Pashley, D. H., & Tay, F. C. M. (2010). In vitro remineralization of severely compromised bonded dentin. Journal of Dental Research, 89(4), 405-410. https://doi.org/10.1177/0022034510363662

In vitro remineralization of severely compromised bonded dentin. / Mai, S.; Kim, Y. K.; Kim, J.; Yiu, C. K.Y.; Ling, J.; Pashley, David Henry; Tay, Franklin Chi Meng.

In: Journal of Dental Research, Vol. 89, No. 4, 01.04.2010, p. 405-410.

Research output: Contribution to journalArticle

Mai, S, Kim, YK, Kim, J, Yiu, CKY, Ling, J, Pashley, DH & Tay, FCM 2010, 'In vitro remineralization of severely compromised bonded dentin', Journal of Dental Research, vol. 89, no. 4, pp. 405-410. https://doi.org/10.1177/0022034510363662
Mai S, Kim YK, Kim J, Yiu CKY, Ling J, Pashley DH et al. In vitro remineralization of severely compromised bonded dentin. Journal of Dental Research. 2010 Apr 1;89(4):405-410. https://doi.org/10.1177/0022034510363662
Mai, S. ; Kim, Y. K. ; Kim, J. ; Yiu, C. K.Y. ; Ling, J. ; Pashley, David Henry ; Tay, Franklin Chi Meng. / In vitro remineralization of severely compromised bonded dentin. In: Journal of Dental Research. 2010 ; Vol. 89, No. 4. pp. 405-410.
@article{283357a84a544ce599b6fa0fbaf152b4,
title = "In vitro remineralization of severely compromised bonded dentin",
abstract = "Biomimetic remineralization is potentially useful for the remineralization of incompletely resin-infiltrated collagen matrices created by etch-and-rinse adhesives. In this study, we tested the hypothesis that structurally altered dentin collagen cannot be remineralized to the same hierarchical order and dimension seen in structurally intact dentin collagen. The remineralization medium consisted of a set Portland cement/simulated body fluid system containing polycarboxylic acid and polyvinylphosphonic acid as biomimetic analogs. Remineralization of air-dried, collapsed hybrid layers was apparent after one month, with hybrid layers remineralized to 80-90{\%} of their thickness after 2-4 months. A hypermineralized layer was seen on the hybrid layer surface, and tubular orifices were occluded with apatite deposits that resembled those present in non-carious cervical dentin. Structurally altered collagen is unlikely to be remineralized to the same hierarchical order and dimension as seen in intact dentin. The aggressively air-dried acid-etched dentin remineralization model also sheds light on the mechanism of sclerotic dentin formation.",
keywords = "Biomimetic analogs, Hypermineralized dentin., Intrafibrillar remineralization, Remineralization, Structurally altered collagen",
author = "S. Mai and Kim, {Y. K.} and J. Kim and Yiu, {C. K.Y.} and J. Ling and Pashley, {David Henry} and Tay, {Franklin Chi Meng}",
year = "2010",
month = "4",
day = "1",
doi = "10.1177/0022034510363662",
language = "English (US)",
volume = "89",
pages = "405--410",
journal = "Journal of Dental Research",
issn = "0022-0345",
publisher = "SAGE Publications Inc.",
number = "4",

}

TY - JOUR

T1 - In vitro remineralization of severely compromised bonded dentin

AU - Mai, S.

AU - Kim, Y. K.

AU - Kim, J.

AU - Yiu, C. K.Y.

AU - Ling, J.

AU - Pashley, David Henry

AU - Tay, Franklin Chi Meng

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Biomimetic remineralization is potentially useful for the remineralization of incompletely resin-infiltrated collagen matrices created by etch-and-rinse adhesives. In this study, we tested the hypothesis that structurally altered dentin collagen cannot be remineralized to the same hierarchical order and dimension seen in structurally intact dentin collagen. The remineralization medium consisted of a set Portland cement/simulated body fluid system containing polycarboxylic acid and polyvinylphosphonic acid as biomimetic analogs. Remineralization of air-dried, collapsed hybrid layers was apparent after one month, with hybrid layers remineralized to 80-90% of their thickness after 2-4 months. A hypermineralized layer was seen on the hybrid layer surface, and tubular orifices were occluded with apatite deposits that resembled those present in non-carious cervical dentin. Structurally altered collagen is unlikely to be remineralized to the same hierarchical order and dimension as seen in intact dentin. The aggressively air-dried acid-etched dentin remineralization model also sheds light on the mechanism of sclerotic dentin formation.

AB - Biomimetic remineralization is potentially useful for the remineralization of incompletely resin-infiltrated collagen matrices created by etch-and-rinse adhesives. In this study, we tested the hypothesis that structurally altered dentin collagen cannot be remineralized to the same hierarchical order and dimension seen in structurally intact dentin collagen. The remineralization medium consisted of a set Portland cement/simulated body fluid system containing polycarboxylic acid and polyvinylphosphonic acid as biomimetic analogs. Remineralization of air-dried, collapsed hybrid layers was apparent after one month, with hybrid layers remineralized to 80-90% of their thickness after 2-4 months. A hypermineralized layer was seen on the hybrid layer surface, and tubular orifices were occluded with apatite deposits that resembled those present in non-carious cervical dentin. Structurally altered collagen is unlikely to be remineralized to the same hierarchical order and dimension as seen in intact dentin. The aggressively air-dried acid-etched dentin remineralization model also sheds light on the mechanism of sclerotic dentin formation.

KW - Biomimetic analogs

KW - Hypermineralized dentin.

KW - Intrafibrillar remineralization

KW - Remineralization

KW - Structurally altered collagen

UR - http://www.scopus.com/inward/record.url?scp=77949646396&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949646396&partnerID=8YFLogxK

U2 - 10.1177/0022034510363662

DO - 10.1177/0022034510363662

M3 - Article

VL - 89

SP - 405

EP - 410

JO - Journal of Dental Research

JF - Journal of Dental Research

SN - 0022-0345

IS - 4

ER -