In vivo response to cross-linked polyethylene and polycarbonate-urethane particles

Richard A. Smith, Anobel Maghsoodpour, Nadim James Hallab

Research output: Contribution to journalArticle

Abstract

This study was undertaken to examine macrophage response to polycarbonate-urethane, a proposed alternative material to polyethylene in acetabular components of total hip arthroplasty. Polyethylene wear debris from total joint replacements has been linked to osteolysis and implant lifespan. It has been shown in vitro, that polyethylene particles cleaned of endotoxin generate less of an inflammatory cytokine response than endotoxin bound particles. Comparative particle induced effects on implant fixation were tested using endotoxin free cross-linked ultra-high molecular weight polyethylene (x-UHMWPE) and polycarbonate-urethane (PCU) particles with and without intraperitoneal injection (IP) of lipopolysaccharide (LPS) using a Ti-alloy femoral intramedullary nail rat model. MicroCT and mechanical testing assessment of peri-implant bone indicated significantly less bone and lower fixation strength, respectively, when the implant was surrounded by xUHMWPE particles compared to PCU particles (with and without LPS IP). This indicates particles of PCU may be less disruptive to bone-implant fixation than x-UHMWPE in vivo, under both LPS free and challenged conditions.

Original languageEnglish (US)
Pages (from-to)227-234
Number of pages8
JournalJournal of Biomedical Materials Research - Part A
Volume93
Issue number1
DOIs
StatePublished - Apr 1 2010
Externally publishedYes

Fingerprint

polycarbonate
Urethane
Polyethylene
Polycarbonates
Ultrahigh molecular weight polyethylenes
Polyethylenes
Endotoxins
Lipopolysaccharides
Bone
Intraperitoneal Injections
Bone and Bones
Replacement Arthroplasties
X-Ray Microtomography
Arthroplasty
Nails
Osteolysis
Mechanical testing
Macrophages
Thigh
Debris

Keywords

  • In vivo
  • Osteolysis
  • Particles
  • Polycarbonate-urethane
  • Polyethylene

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

Cite this

In vivo response to cross-linked polyethylene and polycarbonate-urethane particles. / Smith, Richard A.; Maghsoodpour, Anobel; Hallab, Nadim James.

In: Journal of Biomedical Materials Research - Part A, Vol. 93, No. 1, 01.04.2010, p. 227-234.

Research output: Contribution to journalArticle

Smith, Richard A. ; Maghsoodpour, Anobel ; Hallab, Nadim James. / In vivo response to cross-linked polyethylene and polycarbonate-urethane particles. In: Journal of Biomedical Materials Research - Part A. 2010 ; Vol. 93, No. 1. pp. 227-234.
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