Increased levels of antibodies to heat shock proteins with increasing age in MRL/MP-LPR/LPR mice

G. Faulds, S. Conroy, Michael P. Madaio, D. Isenberg, D. Latchman

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Approximately 30% of human patients with systemic lupus erythematosus (SLE) develop IgG autoantibodies to the highly conserved 90 kDa heat shock protein (hsp90). The development of anti-hsp90 antibodies is shown here to be paralleled in the Mrl/lpr mouse, which is an acknowledged model for SLE, but not in control BALB/c mice (P = 0.005). The generation of these antibodies appears to be closely linked to the onset of disease and titres of these antibodies increase with age, but there is no correlation with well-established clinical parameters of disease. Antibodies to hsp70 and hsp65 are also observed in the Mrl/lpr model; these antibodies appear to be unrelated to the pathogenesis of the disease.

Original languageEnglish (US)
Pages (from-to)610-615
Number of pages6
JournalRheumatology
Volume34
Issue number7
DOIs
StatePublished - Jul 1 1995

Fingerprint

Heat Shock Protein
Heat-Shock Proteins
antibodies
Antibody
Antibodies
mice
Mouse
shock
proteins
Proteins
heat
Systemic Lupus Erythematosus
HSP90 Heat-Shock Proteins
Autoantibodies
pathogenesis
Anti-Idiotypic Antibodies
Immunoglobulin G
Hot Temperature
Model

Keywords

  • Autoantibodies
  • Heat shock proteins
  • Mrl/lpr mouse
  • SLE

ASJC Scopus subject areas

  • Molecular Biology
  • Statistics and Probability
  • Computational Mathematics
  • Condensed Matter Physics
  • Applied Mathematics
  • Pharmacology (medical)
  • Rheumatology
  • Neuroscience(all)

Cite this

Increased levels of antibodies to heat shock proteins with increasing age in MRL/MP-LPR/LPR mice. / Faulds, G.; Conroy, S.; Madaio, Michael P.; Isenberg, D.; Latchman, D.

In: Rheumatology, Vol. 34, No. 7, 01.07.1995, p. 610-615.

Research output: Contribution to journalArticle

Faulds, G. ; Conroy, S. ; Madaio, Michael P. ; Isenberg, D. ; Latchman, D. / Increased levels of antibodies to heat shock proteins with increasing age in MRL/MP-LPR/LPR mice. In: Rheumatology. 1995 ; Vol. 34, No. 7. pp. 610-615.
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