Increased levels of antibodies to heat shock proteins with increasing age in MRL/MP-LPR/LPR mice

G. Faulds, S. Conroy, Michael P. Madaio, D. Isenberg, D. Latchman

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Abstract

Approximately 30% of human patients with systemic lupus erythematosus (SLE) develop IgG autoantibodies to the highly conserved 90 kDa heat shock protein (hsp90). The development of anti-hsp90 antibodies is shown here to be paralleled in the Mrl/lpr mouse, which is an acknowledged model for SLE, but not in control BALB/c mice (P = 0.005). The generation of these antibodies appears to be closely linked to the onset of disease and titres of these antibodies increase with age, but there is no correlation with well-established clinical parameters of disease. Antibodies to hsp70 and hsp65 are also observed in the Mrl/lpr model; these antibodies appear to be unrelated to the pathogenesis of the disease.

Original languageEnglish (US)
Pages (from-to)610-615
Number of pages6
JournalRheumatology
Volume34
Issue number7
DOIs
Publication statusPublished - Jul 1 1995

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Keywords

  • Autoantibodies
  • Heat shock proteins
  • Mrl/lpr mouse
  • SLE

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

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