Increased motor neuron projection during development does not increase the number of neuromuscular synapses

G. S. Sohal, T. Arumugam, Thomas Robert Swift

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We investigated in developing embryos whether the total number of neuromuscular synapses is determined by the muscle or by the number of innervating motor neurons. The superior oblique muscle of duck embryos was hyperinnervated by preventing the naturally occurring death of trochlear motor neurons using immunoglobulin G from patients with acquired myasthenia gravis. In spite of a significant increase in the number of motor neurons innervating the muscle, a corresponding increase in the number of neuromuscular synapses did not occur. These results suggest that the total number of synapses in a muscle is independent of the number of innervating motor neurons and that it is determined intrinsically by the muscle itself.

Original languageEnglish (US)
Pages (from-to)284-288
Number of pages5
JournalExperimental Neurology
Volume92
Issue number1
DOIs
StatePublished - Jan 1 1986

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Motor Neurons
Synapses
Muscles
Oculomotor Muscles
Embryonic Structures
Ducks
Myasthenia Gravis
Immunoglobulin G

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Increased motor neuron projection during development does not increase the number of neuromuscular synapses. / Sohal, G. S.; Arumugam, T.; Swift, Thomas Robert.

In: Experimental Neurology, Vol. 92, No. 1, 01.01.1986, p. 284-288.

Research output: Contribution to journalArticle

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