Abstract
Sustained access to nutrients is a fundamental biological need, especially for proliferating cells, and controlling nutrient supply is an ancient strategy to regulate cellular responses to stimuli. By catabolizing the essential amino acid TRP, cells expressing the enzyme indoleamine 2,3 dioxygenase (IDO) can mediate potent local effects on innate and adaptive immune responses to inflammatory insults. Here, we discuss recent progress in elucidating how IDO activity promotes local metabolic changes that impact cellular and systemic responses to inflammatory and immunological signals. These recent developments identify potential new targets for therapy in a range of clinical settings, including cancer, chronic infections, autoimmune and allergic syndromes, and transplantation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 137-143 |
| Number of pages | 7 |
| Journal | Trends in Immunology |
| Volume | 34 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2013 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Indoleamine 2,3 dioxygenase and metabolic control of immune responses. / Munn, David H.; Mellor, Andrew L.
In: Trends in Immunology, Vol. 34, No. 3, 01.03.2013, p. 137-143.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Indoleamine 2,3 dioxygenase and metabolic control of immune responses
AU - Munn, David H.
AU - Mellor, Andrew L.
PY - 2013/3/1
Y1 - 2013/3/1
N2 - Sustained access to nutrients is a fundamental biological need, especially for proliferating cells, and controlling nutrient supply is an ancient strategy to regulate cellular responses to stimuli. By catabolizing the essential amino acid TRP, cells expressing the enzyme indoleamine 2,3 dioxygenase (IDO) can mediate potent local effects on innate and adaptive immune responses to inflammatory insults. Here, we discuss recent progress in elucidating how IDO activity promotes local metabolic changes that impact cellular and systemic responses to inflammatory and immunological signals. These recent developments identify potential new targets for therapy in a range of clinical settings, including cancer, chronic infections, autoimmune and allergic syndromes, and transplantation.
AB - Sustained access to nutrients is a fundamental biological need, especially for proliferating cells, and controlling nutrient supply is an ancient strategy to regulate cellular responses to stimuli. By catabolizing the essential amino acid TRP, cells expressing the enzyme indoleamine 2,3 dioxygenase (IDO) can mediate potent local effects on innate and adaptive immune responses to inflammatory insults. Here, we discuss recent progress in elucidating how IDO activity promotes local metabolic changes that impact cellular and systemic responses to inflammatory and immunological signals. These recent developments identify potential new targets for therapy in a range of clinical settings, including cancer, chronic infections, autoimmune and allergic syndromes, and transplantation.
UR - http://www.scopus.com/inward/record.url?scp=84875261622&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875261622&partnerID=8YFLogxK
U2 - 10.1016/j.it.2012.10.001
DO - 10.1016/j.it.2012.10.001
M3 - Review article
C2 - 23103127
AN - SCOPUS:84875261622
VL - 34
SP - 137
EP - 143
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 3
ER -