@article{8961ef396e5f4fb0ad3a8574adbaf455,
title = "Infant locomotive development and its association with adult blood pressure",
abstract = "Evidence from animal models suggests that locomotion and blood pressure share common neurophysiological regulatory systems. As a result of this common regulation, we hypothesized that the development of locomotion in human infants would be associated with blood pressure levels in adulthood. The study sample comprised 4,347 individuals with measures of locomotive and non-locomotive neuromotor development in infancy and adult blood pressure levels within a longitudinal birth cohort study, the Northern Finland Birth Cohort 1966. Later development in all three stages of locomotive development during infancy was associated with higher systolic and diastolic blood pressure levels at age 31. For age of walking without support, 0.34 (95 % CI 0.07 to 0.60)-mm Hg higher SBP and 0.38 (95 % CI 0.15 to 0.62)-mm Hg higher DBP were estimated for each month of later achievement (P = 0.012 for SBP; P = 0.001 for DBP). No association was identified for non-locomotive neuromotor development. Conclusion: These results highlight the positive sequelae of advanced locomotive development during infancy, suggesting that the common regulatory systems between locomotion and blood pressure may influence the development of raised blood pressure over time.",
keywords = "Blood pressure, Child development, Cohort studies, Epidemiology, Infancy, Neurodevelopment",
author = "Demetris Pillas and Marika Kaakinen and Ioanna Tzoulaki and Gopalakrishnan Netuveli and Alina Rodriguez and Erik Fung and Tammelin, {Tuija H.} and David Blane and Millwood, {Iona Y.} and Rebecca Hardy and Ulla Sovio and Anneli Pouta and Hopstock, {Laila Arnesdatter} and Hartikainen, {Anna Liisa} and Jaana Laitinen and Sarianna Vaara and Khan, {Anokhi Ali} and Chong, {Kwong Yew Raymond} and Paul Elliott and Jarvelin, {Marjo Riitta}",
note = "Funding Information: Funding source The NFBC1966 received financial support from the Academy of Finland (project grants 104781, 120315, 129269, 1114194, 24300796,), University Hospital Oulu, Biocenter, University of Oulu, Finland (75617), European Regional Development Fund grant no. 539/ 2010 A31592, ENGAGE project and grant agreement HEALTH-F4-2007-201413, and the Medical Research Council, UK (G0500539, G0600705, G1002319, PrevMetSyn/SALVE). D.P. is supported by the Division of Epidemiology, Public Health and Primary Care (DFHM G24038). P.E. is supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Imperial College Healthcare NHS Trust and Imperial College London. P.E. is an NIHR Senior Investigator. G.N. is supported by ESRC grant RES-596-28-0001. A.R. is partially supported by grants from VINNOVA (VINNMER) and the Swedish Council for Working Life and Social Sciences (FAS). R.H. is supported by the Medical Research Council (MC_UU_12019/2). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health. Publisher Copyright: {\textcopyright} 2014, Springer-Verlag Berlin Heidelberg.",
year = "2014",
month = sep,
day = "12",
doi = "10.1007/s00431-014-2326-2",
language = "English (US)",
volume = "173",
pages = "1309--1317",
journal = "Acta Paediatrica Hungarica",
issn = "0340-6199",
publisher = "Springer Verlag",
number = "10",
}