Abstract
Evidence from animal models suggests that locomotion and blood pressure share common neurophysiological regulatory systems. As a result of this common regulation, we hypothesized that the development of locomotion in human infants would be associated with blood pressure levels in adulthood. The study sample comprised 4,347 individuals with measures of locomotive and non-locomotive neuromotor development in infancy and adult blood pressure levels within a longitudinal birth cohort study, the Northern Finland Birth Cohort 1966. Later development in all three stages of locomotive development during infancy was associated with higher systolic and diastolic blood pressure levels at age 31. For age of walking without support, 0.34 (95 % CI 0.07 to 0.60)-mm Hg higher SBP and 0.38 (95 % CI 0.15 to 0.62)-mm Hg higher DBP were estimated for each month of later achievement (P = 0.012 for SBP; P = 0.001 for DBP). No association was identified for non-locomotive neuromotor development. Conclusion: These results highlight the positive sequelae of advanced locomotive development during infancy, suggesting that the common regulatory systems between locomotion and blood pressure may influence the development of raised blood pressure over time.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1309-1317 |
| Number of pages | 9 |
| Journal | European Journal of Pediatrics |
| Volume | 173 |
| Issue number | 10 |
| DOIs | |
| State | Published - Sep 12 2014 |
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Keywords
- Blood pressure
- Child development
- Cohort studies
- Epidemiology
- Infancy
- Neurodevelopment
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Infant locomotive development and its association with adult blood pressure. / Pillas, Demetris; Kaakinen, Marika; Tzoulaki, Ioanna; Netuveli, Gopalakrishnan; Rodriguez, Alina; Fung, Erik; Tammelin, Tuija H.; Blane, David; Millwood, Iona Y.; Hardy, Rebecca; Sovio, Ulla; Pouta, Anneli; Hopstock, Laila Arnesdatter; Hartikainen, Anna Liisa; Laitinen, Jaana; Vaara, Sarianna; Khan, Anokhi Ali; Chong, Kwong Yew Raymond; Elliott, Paul; Jarvelin, Marjo Riitta.
In: European Journal of Pediatrics, Vol. 173, No. 10, 12.09.2014, p. 1309-1317.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Infant locomotive development and its association with adult blood pressure
AU - Pillas, Demetris
AU - Kaakinen, Marika
AU - Tzoulaki, Ioanna
AU - Netuveli, Gopalakrishnan
AU - Rodriguez, Alina
AU - Fung, Erik
AU - Tammelin, Tuija H.
AU - Blane, David
AU - Millwood, Iona Y.
AU - Hardy, Rebecca
AU - Sovio, Ulla
AU - Pouta, Anneli
AU - Hopstock, Laila Arnesdatter
AU - Hartikainen, Anna Liisa
AU - Laitinen, Jaana
AU - Vaara, Sarianna
AU - Khan, Anokhi Ali
AU - Chong, Kwong Yew Raymond
AU - Elliott, Paul
AU - Jarvelin, Marjo Riitta
PY - 2014/9/12
Y1 - 2014/9/12
N2 - Evidence from animal models suggests that locomotion and blood pressure share common neurophysiological regulatory systems. As a result of this common regulation, we hypothesized that the development of locomotion in human infants would be associated with blood pressure levels in adulthood. The study sample comprised 4,347 individuals with measures of locomotive and non-locomotive neuromotor development in infancy and adult blood pressure levels within a longitudinal birth cohort study, the Northern Finland Birth Cohort 1966. Later development in all three stages of locomotive development during infancy was associated with higher systolic and diastolic blood pressure levels at age 31. For age of walking without support, 0.34 (95 % CI 0.07 to 0.60)-mm Hg higher SBP and 0.38 (95 % CI 0.15 to 0.62)-mm Hg higher DBP were estimated for each month of later achievement (P = 0.012 for SBP; P = 0.001 for DBP). No association was identified for non-locomotive neuromotor development. Conclusion: These results highlight the positive sequelae of advanced locomotive development during infancy, suggesting that the common regulatory systems between locomotion and blood pressure may influence the development of raised blood pressure over time.
AB - Evidence from animal models suggests that locomotion and blood pressure share common neurophysiological regulatory systems. As a result of this common regulation, we hypothesized that the development of locomotion in human infants would be associated with blood pressure levels in adulthood. The study sample comprised 4,347 individuals with measures of locomotive and non-locomotive neuromotor development in infancy and adult blood pressure levels within a longitudinal birth cohort study, the Northern Finland Birth Cohort 1966. Later development in all three stages of locomotive development during infancy was associated with higher systolic and diastolic blood pressure levels at age 31. For age of walking without support, 0.34 (95 % CI 0.07 to 0.60)-mm Hg higher SBP and 0.38 (95 % CI 0.15 to 0.62)-mm Hg higher DBP were estimated for each month of later achievement (P = 0.012 for SBP; P = 0.001 for DBP). No association was identified for non-locomotive neuromotor development. Conclusion: These results highlight the positive sequelae of advanced locomotive development during infancy, suggesting that the common regulatory systems between locomotion and blood pressure may influence the development of raised blood pressure over time.
KW - Blood pressure
KW - Child development
KW - Cohort studies
KW - Epidemiology
KW - Infancy
KW - Neurodevelopment
UR - http://www.scopus.com/inward/record.url?scp=84918795259&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84918795259&partnerID=8YFLogxK
U2 - 10.1007/s00431-014-2326-2
DO - 10.1007/s00431-014-2326-2
M3 - Article
C2 - 24804637
AN - SCOPUS:84918795259
VL - 173
SP - 1309
EP - 1317
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
SN - 0340-6199
IS - 10
ER -