Inflammation and Hypertension: New Understandings and Potential Therapeutic Targets

Carmen De Miguel; Nathan P. Rudemiller; Justine M. Abais; David L. Mattson

doi:10.1007/s11906-014-0507-z

Inflammation and Hypertension: New Understandings and Potential Therapeutic Targets

Carmen De Miguel, Nathan P. Rudemiller, Justine M. Abais, David L. Mattson

Research output: Contribution to journal › Review article › peer-review

163 Scopus citations

Abstract

Research studying the role of inflammation in hypertension and cardiovascular disease has flourished in recent years; however, the exact mechanisms by which the activated immune cells lead to the development and maintenance of hypertension remain to be elucidated. The objectives of this brief review are to summarize and discuss the most recent findings in the field, with special emphasis on potential therapeutics to treat or prevent hypertension. This review will cover novel immune cell subtypes recently associated to the disease including the novel role of cytokines, toll-like receptors, and inflammasomes in hypertension.

Original language	English (US)
Journal	Current Hypertension Reports
Volume	17
Issue number	1
DOIs	https://doi.org/10.1007/s11906-014-0507-z
State	Published - 2015
Externally published	Yes

Keywords

Cytokines
Immunity
Inflammasome
T lymphocytes
Toll-like receptors

ASJC Scopus subject areas

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11906-014-0507-z

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title = "Inflammation and Hypertension: New Understandings and Potential Therapeutic Targets",

abstract = "Research studying the role of inflammation in hypertension and cardiovascular disease has flourished in recent years; however, the exact mechanisms by which the activated immune cells lead to the development and maintenance of hypertension remain to be elucidated. The objectives of this brief review are to summarize and discuss the most recent findings in the field, with special emphasis on potential therapeutics to treat or prevent hypertension. This review will cover novel immune cell subtypes recently associated to the disease including the novel role of cytokines, toll-like receptors, and inflammasomes in hypertension.",

keywords = "Cytokines, Immunity, Inflammasome, T lymphocytes, Toll-like receptors",

author = "{De Miguel}, Carmen and Rudemiller, {Nathan P.} and Abais, {Justine M.} and Mattson, {David L.}",

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year = "2015",

doi = "10.1007/s11906-014-0507-z",

language = "English (US)",

volume = "17",

journal = "Current Hypertension Reports",

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T1 - Inflammation and Hypertension

T2 - New Understandings and Potential Therapeutic Targets

AU - De Miguel, Carmen

AU - Rudemiller, Nathan P.

AU - Abais, Justine M.

AU - Mattson, David L.

PY - 2015

Y1 - 2015

N2 - Research studying the role of inflammation in hypertension and cardiovascular disease has flourished in recent years; however, the exact mechanisms by which the activated immune cells lead to the development and maintenance of hypertension remain to be elucidated. The objectives of this brief review are to summarize and discuss the most recent findings in the field, with special emphasis on potential therapeutics to treat or prevent hypertension. This review will cover novel immune cell subtypes recently associated to the disease including the novel role of cytokines, toll-like receptors, and inflammasomes in hypertension.

AB - Research studying the role of inflammation in hypertension and cardiovascular disease has flourished in recent years; however, the exact mechanisms by which the activated immune cells lead to the development and maintenance of hypertension remain to be elucidated. The objectives of this brief review are to summarize and discuss the most recent findings in the field, with special emphasis on potential therapeutics to treat or prevent hypertension. This review will cover novel immune cell subtypes recently associated to the disease including the novel role of cytokines, toll-like receptors, and inflammasomes in hypertension.

KW - Cytokines

KW - Immunity

KW - Inflammasome

KW - T lymphocytes

KW - Toll-like receptors

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DO - 10.1007/s11906-014-0507-z

M3 - Review article

C2 - 25432899

AN - SCOPUS:84935913919

SN - 1522-6417

VL - 17

JO - Current Hypertension Reports

JF - Current Hypertension Reports

IS - 1

ER -

Inflammation and Hypertension: New Understandings and Potential Therapeutic Targets

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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