Inflammation and Hypertension: New Understandings and Potential Therapeutic Targets

Carmen De Miguel, Nathan P. Rudemiller, Justine M. Abais, David L. Mattson

Research output: Contribution to journalReview article

71 Scopus citations

Abstract

Research studying the role of inflammation in hypertension and cardiovascular disease has flourished in recent years; however, the exact mechanisms by which the activated immune cells lead to the development and maintenance of hypertension remain to be elucidated. The objectives of this brief review are to summarize and discuss the most recent findings in the field, with special emphasis on potential therapeutics to treat or prevent hypertension. This review will cover novel immune cell subtypes recently associated to the disease including the novel role of cytokines, toll-like receptors, and inflammasomes in hypertension.

Original languageEnglish (US)
JournalCurrent Hypertension Reports
Volume17
Issue number1
DOIs
StatePublished - Nov 29 2014

Keywords

  • Cytokines
  • Immunity
  • Inflammasome
  • T lymphocytes
  • Toll-like receptors

ASJC Scopus subject areas

  • Internal Medicine

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