Inflammatory Pathways in Psychiatric Disorders: the Case of Schizophrenia and Depression

Tami Feng, Ashutosh Tripathi, Anilkumar Pillai

Research output: Contribution to journalReview article

Abstract

Purpose of Review: A better understanding of the key molecules/pathways underlying the pathophysiology of depression and schizophrenia may contribute to novel therapeutic strategies. In this review, we have discussed the recent developments on the role of inflammatory pathways in the pathogenesis of depression and schizophrenia. Recent Findings: Inflammation is an innate immune response that can be triggered by various factors, including pathogens, stress, and injury. Under normal conditions, the inflammatory responses quiet after pathogen clearance and tissue repair. However, abnormal long-term or chronic inflammation can lead to damaging effects. Accumulating evidence suggest that dysregulated inflammation is linked to the pathogenesis of neuropsychiatric disorders. In this review, we have discussed the roles of complement system, infiltration of peripheral immune cells into the central nervous system (CNS), the gut-brain axis, and the kynurenine pathway in depression and schizophrenia. Summary: There is a large body of compelling evidence on the role of inflammatory pathways in depression and schizophrenia. Although most of these findings show their roles in the pathophysiology of the above disorders, additional studies are warranted to investigate the therapeutic potential of various immune signaling targets discussed in this article.

Original languageEnglish (US)
Pages (from-to)128-138
Number of pages11
JournalCurrent Behavioral Neuroscience Reports
Volume7
Issue number3
DOIs
StatePublished - Sep 1 2020

Keywords

  • Complement system
  • Depression
  • Gut-brain axis and kynurenine pathway
  • Infiltration
  • Inflammation
  • Schizophrenia

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Behavioral Neuroscience

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