Influence of eicosanoids on renal function of DOCA-salt hypertensive rats

R. J. Roman, M. L. Kaldunski, D. L. Mattson, M. Mistry, A. Nasjletti

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The present study examined the contribution of changes in the synthesis or degradation (or both) of renal eicosanoids to the alterations in renal hemodynamics observed in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Renal blood flow and glomerular filtration rate were markedly reduced in DOCA-salt hypertensive rats compared with values observed in controls rats given water or saline to drink. The abnormalities in renal hemodynamics in the hypertensive rats were associated with an increase in the excretion of thromboxane B2, an increase in the release of thromboxane B2 from renal cortical tissue slices, and a diminished release of prostaglandin E2 (PGE2) from renal medullary tissue. Additionally, the urinary excretion of PGE2 and 6-keto-prostaglandin F(1α) (6-keto-PGF(1α)) and the release of 6-keto-PGF(1α) from renal cortical and medullary tissue were elevated in rats with DOCA-salt hypertension. Since the excretion of PFE2 and 6-keto-PGF(1α) and the release of 6-keto-PGF(1α) by medullary tissue were also elevated in normotensive rats given 1% NaCl solution to drink, these latter changes probably were related to an elevation of sodium intake rather than to the development of hypertension. The functional significance of the alterations in the renal production of thromboxane in DOCA-salt hypertensive rats was evaluated by comparing the effects of a thromboxane synthesis inhibitor and a receptor antagonist on renal function in normotensive and DOCA-salt hypertensive rats. The administration of the thromboxabe synthetase inhibitor furegrelate and the thromboxane receptor blocker SQ 29548 had no effect on renal hemodynamics in either group. These results suggest that the elevated renal production of thromboxane A2 is not responsible for the reduction of renal blood flow and glomerular filtration rate in rats with established DOCA-salt hypertension.

Original languageEnglish (US)
Pages (from-to)287-294
Number of pages8
JournalHypertension
Volume12
Issue number3
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Internal Medicine

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