Influence of mild to moderate obesity on left ventricular stress filling pattern in hypertension

Shinji Seto, Kakota Gaston Kapuku, Fumitaka Kawahara, Shin Suzuki, Katsusuke Yano

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In resting condition, obese subjects are described as having impaired diastolic filling. To examine the effect of mild to moderate obesity on left ventricular diastolic performance during stress in hypertension, we determined the filling responses to dynamic submaximal exercise in 19 obese hypertensive patients (body mass index, 26 to 30 kg/m2) with a normal left ventricular structure, 19 age- and sex-matched, non-obese hypertensive patients, and 19 age- and sex-matched, non-obese normotensive controls (mean age, 55 ± 3 yr). Doppler echocardiographic studies were performed at baseline and 1 min after exercise on a supine ergometer bicycle. At rest, systolic function and filling indices, peak velocities of early (E) and late (A) filling, and their ratio (E/A), were similar in the two hypertensive groups, while normotensive controls had higher peak velocities of E and E/A. At a maximum workload of 75 W, blood pressure and heart rate increased similarly in the two hypertensive groups. Peak velocities of E and A increased significantly after exercise. The percentage change in the peak velocity of E was greater in obese hypertensive patients than in non-obese hypertensive patients and normotensive controls (23 ± 4 vs. 12 ± 3 and 14 ± 3%, p < 0.05). Percentage changes in A and E/A were similar in the three groups. Our study suggests that mild to moderate obesity does not further worsen left ventricular diastolic filling at rest and mitigates diastolic filling abnormalities after exercise in hypertensive patients.

Original languageEnglish (US)
Pages (from-to)245-250
Number of pages6
JournalHypertension Research - Clinical and Experimental
Volume21
Issue number4
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

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Obesity
Hypertension
Exercise
Workload
Body Mass Index
Heart Rate
Blood Pressure

Keywords

  • Diastolic function
  • Hypertension
  • Obesity
  • Pulsed Doppler echocardiography

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Influence of mild to moderate obesity on left ventricular stress filling pattern in hypertension. / Seto, Shinji; Kapuku, Kakota Gaston; Kawahara, Fumitaka; Suzuki, Shin; Yano, Katsusuke.

In: Hypertension Research - Clinical and Experimental, Vol. 21, No. 4, 01.01.1998, p. 245-250.

Research output: Contribution to journalArticle

Seto, Shinji ; Kapuku, Kakota Gaston ; Kawahara, Fumitaka ; Suzuki, Shin ; Yano, Katsusuke. / Influence of mild to moderate obesity on left ventricular stress filling pattern in hypertension. In: Hypertension Research - Clinical and Experimental. 1998 ; Vol. 21, No. 4. pp. 245-250.
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